What are the mechanisms of transdermal drug delivery and factors that affect skin absorption?
Understand the Problem
The question appears to involve understanding transdermal drug delivery systems, including skin transport mechanisms, physiological processes involved, and factors affecting drug absorption through the skin. It also touches on the effect of vehicle types used for drug delivery and their influence on hydration and permeability.
Answer
Passive diffusion through skin layers; affected by skin condition, age, hydration, and formulation.
The mechanisms include passive diffusion through the stratum corneum, bypassing the deeper epidermis and dermis. Factors affecting absorption are skin condition, age, hydration, and formulation characteristics.
Answer for screen readers
The mechanisms include passive diffusion through the stratum corneum, bypassing the deeper epidermis and dermis. Factors affecting absorption are skin condition, age, hydration, and formulation characteristics.
More Information
Transdermal drug delivery provides a painless and effective way to administer systemic drugs by adhering to skin, making it ideal for prolonged or controlled release therapies.
Tips
A common mistake is underestimating the barrier properties of the stratum corneum, leading to insufficient drug penetration or absorption.
Sources
- Transdermal Drug Delivery (TDD) - PMC - ncbi.nlm.nih.gov
- Enhancement strategies for transdermal drug delivery systems - NCBI - ncbi.nlm.nih.gov
- Transdermal Drug Administration - ScienceDirect Topics - sciencedirect.com
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