Demonstrate understanding of the significance of polymorphisms in human P450s.
Understand the Problem
The question is asking us to explain the importance of polymorphisms in human cytochrome P450 enzymes, particularly focusing on their role in drug metabolism and how genetic variations can differ among ethnic groups.
Answer
P450 polymorphisms affect drug metabolism, influencing therapeutic efficacy and toxicity. Understanding them aids personalized medicine.
Polymorphisms in human P450 enzymes significantly affect drug metabolism and individual reactions to medications. These genetic variations can lead to altered enzyme activity, impacting therapeutic efficacy and toxicity. Understanding these polymorphisms helps tailor personalized medicine, particularly in dosing and drug selection to minimize adverse effects.
Answer for screen readers
Polymorphisms in human P450 enzymes significantly affect drug metabolism and individual reactions to medications. These genetic variations can lead to altered enzyme activity, impacting therapeutic efficacy and toxicity. Understanding these polymorphisms helps tailor personalized medicine, particularly in dosing and drug selection to minimize adverse effects.
More Information
Cytochrome P450 enzymes are involved in the metabolism of over 90% of drugs. Genetic polymorphisms in these enzymes often lead to variations in drug responses among individuals, making some populations more susceptible to drug toxicity or reduced efficacy.
Tips
A common mistake is to overlook the impact of P450 polymorphisms on the efficacy of non-therapeutic substances such as caffeine or alcohol, not just medications. It is important to consider these variations in broader contexts beyond traditional medications.
Sources
- Polymorphism of human cytochrome P450 enzymes and its clinical ... - pubmed.ncbi.nlm.nih.gov
- Polymorphic Cytochrome P450 Enzymes (CYPs) and Their Role in ... - pmc.ncbi.nlm.nih.gov
- Genetic Polymorphism and Toxicology—With Emphasis on ... - academic.oup.com
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