Albumin is a major plasma protein in the body. A bound drug that binds to albumin becomes inactive, while a free drug is active. Most drugs are acidic and bind to albumin, whereas... Albumin is a major plasma protein in the body. A bound drug that binds to albumin becomes inactive, while a free drug is active. Most drugs are acidic and bind to albumin, whereas many local anesthetics are basic. The question also discusses physiological barriers, such as the blood-brain barrier, which is relevant in conditions like meningitis. It notes that higher rates of blood flow lead to rapid distribution, with organs like the brain, kidney, and liver having high blood flow rates, while lower blood flow organs include skin, adipose tissue, and muscle. Lastly, it mentions that lipophilic drugs have a higher affinity for fatty tissues and act as reservoirs.
Understand the Problem
The question is outlining the characteristics and behaviors of drugs in relation to plasma proteins, their active and inactive states, physiological barriers like the blood-brain barrier, and how blood flow affects drug distribution. It explains how different organs receive varying rates of blood flow which influences the pharmacokinetics of drugs.
Answer
Albumin binds most acidic drugs making them inactive; local anesthetics are basic.
Albumin is a major plasma protein that binds to most acidic drugs, rendering them inactive, whereas free drugs remain active. Local anesthetics, which are often basic, have different binding characteristics and are influenced by factors like plasma pH.
Answer for screen readers
Albumin is a major plasma protein that binds to most acidic drugs, rendering them inactive, whereas free drugs remain active. Local anesthetics, which are often basic, have different binding characteristics and are influenced by factors like plasma pH.
More Information
Albumin is not only the most abundant plasma protein but plays a crucial role in drug pharmacokinetics by binding to many drugs, particularly acidic ones, which affects their distribution and activity. In contrast, local anesthetics' efficacy can be influenced by plasma pH.
Tips
A common mistake is to assume that all drugs bind to albumin in the same way regardless of their chemical properties.
Sources
- Plasma protein binding - Wikipedia - en.wikipedia.org
- Physiology, Albumin - StatPearls - NCBI Bookshelf - ncbi.nlm.nih.gov
- Local Anesthetics: Introduction and History, Mechanism of Action ... - emedicine.medscape.com
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