Wound Healing Process
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Questions and Answers

What is the primary function of neutrophils in the inflammatory response?

  • To release cytokines and growth factors
  • To form a thrombus
  • To synthesize matrix proteins
  • To remove bacteria and foreign material through phagocytosis (correct)

    • Which of the following growth factors is involved in the recruitment of cells to the wound site?

  • Leukotrienes
  • PDGF (correct)
  • TGFβ
  • Prostaglandins

    • What is the primary difference between regeneration and repair in wound healing?

  • Regeneration is a response to minor wounds, whereas repair is a response to major wounds.
  • Regeneration involves a faster healing process, whereas repair involves a slower healing process.
  • Regeneration replaces lost tissue with the same type, whereas repair replaces lost tissue with fibrous scar tissue. (correct)
  • Regeneration occurs in skin wounds, whereas repair occurs in bone wounds.

    • What is the main purpose of the haemostasis phase in wound healing?

    <p>To stop bleeding and promote vasoconstriction.</p> Signup and view all the answers

    What is the primary function of platelets in the coagulation process?

    <p>To form a thrombus</p> Signup and view all the answers

    What is the main reason why oral wounds heal faster and without scarring?

    <p>The oral environment is more conducive to wound healing due to the presence of saliva and other factors.</p> Signup and view all the answers

    Which of the following is NOT a key cell involved in the inflammatory response?

    <p>Fibroblast</p> Signup and view all the answers

    What is the primary factor that determines whether wound healing proceeds through regeneration or repair?

    <p>All of the above.</p> Signup and view all the answers

    What is the primary function of macrophages in the inflammatory response?

    <p>To remove bacteria and foreign material through phagocytosis</p> Signup and view all the answers

    What is the primary consequence of delayed wound healing?

    <p>All of the above.</p> Signup and view all the answers

    Which of the following is involved in the vasodilation response during inflammation?

    <p>Histamine</p> Signup and view all the answers

    What is the primary goal of wound healing?

    <p>To restore tissue integrity and function.</p> Signup and view all the answers

    What is the primary function of fibroblasts in the proliferation phase of wound healing?

    <p>To synthesize matrix proteins</p> Signup and view all the answers

    What is the primary reason why wound healing is a major concern in healthcare systems?

    <p>The high cost of wound care and management.</p> Signup and view all the answers

    What is a characteristic of chronic wounds?

    <p>Accumulation of pro-inflammatory signals &amp; macrophages</p> Signup and view all the answers

    Which of the following is NOT a factor affecting wound healing?

    <p>Genetic predisposition</p> Signup and view all the answers

    What is the purpose of hyperbaric oxygen therapy in wound care?

    <p>To promote angiogenesis</p> Signup and view all the answers

    What is the main difference in wound healing between oral and skin wounds?

    <p>Oral wounds heal quicker than skin wounds</p> Signup and view all the answers

    What is the role of saliva in oral wound healing?

    <p>Saliva is antibacterial and increases clotting time</p> Signup and view all the answers

    What is the purpose of recombinant growth factors in wound care?

    <p>To promote angiogenesis</p> Signup and view all the answers

    What is a characteristic of hypertrophic scars?

    <p>A macroscopic disturbance of the normal structure and function of the skin architecture</p> Signup and view all the answers

    Which type of collagen is replaced by bundles of type I collagen during the remodelling phase of wound healing?

    <p>Type III</p> Signup and view all the answers

    What is the main function of macrophages in the granulation tissue during wound healing?

    <p>To phagocytose and secrete</p> Signup and view all the answers

    What is the percentage of wound strength achieved at 7-10 days after injury?

    <p>10%</p> Signup and view all the answers

    Which vitamin is essential for the cross-linking of collagen I, which provides strength to the wound?

    <p>Vitamin C</p> Signup and view all the answers

    What is the term for the process by which new blood vessels are formed during wound healing?

    <p>Angiogenesis</p> Signup and view all the answers

    Which type of wound healing is characterized by the edges of the wound being apposed and held in place by mechanical means?

    <p>Primary intention</p> Signup and view all the answers

    What is the term for the process by which the provisional matrix is rearranged to form a stronger and more organized tissue during wound healing?

    <p>Remodelling</p> Signup and view all the answers

    What is the main function of fibroblasts in the granulation tissue during wound healing?

    <p>To produce collagen</p> Signup and view all the answers

    At what stage of wound healing does type I collagen become the dominant collagen type?

    <p>Remodelling</p> Signup and view all the answers

    What is the term for the process by which the wound is closed naturally by means of granulation and contraction?

    <p>Secondary intention</p> Signup and view all the answers

    What is the primary reason for delayed bone healing?

    <p>All of the above</p> Signup and view all the answers

    Which factor can negatively impact wound healing?

    <p>Steroids</p> Signup and view all the answers

    What is a characteristic of chronic wounds?

    <p>Accumulation of pro-inflammatory signals</p> Signup and view all the answers

    What is the purpose of hyperbaric oxygen therapy in wound care?

    <p>To increase oxygen delivery to the wound</p> Signup and view all the answers

    What is the primary difference between oral and skin wound healing?

    <p>Oral wounds heal faster and with less scarring</p> Signup and view all the answers

    What determines whether wound healing proceeds through regeneration or repair?

    <p>Cell type and tissue architecture</p> Signup and view all the answers

    What is the primary function of maggot therapy in wound care?

    <p>To promote debridement</p> Signup and view all the answers

    What is the main difference between wound healing in oral and skin wounds?

    <p>Oral wounds heal faster due to better blood supply</p> Signup and view all the answers

    What is the primary difference between primary and secondary intention?

    <p>Primary intention involves immediate closure of the wound, secondary intention involves delayed closure</p> Signup and view all the answers

    What is the primary goal of wound healing?

    <p>To restore tissue function</p> Signup and view all the answers

    What is the role of vasoconstriction in the haemostasis phase?

    <p>To decrease blood flow to the wound</p> Signup and view all the answers

    What is the primary consequence of delayed wound healing?

    <p>All of the above</p> Signup and view all the answers

    What is the main function of the coagulation cascade in wound healing?

    <p>To stop bleeding</p> Signup and view all the answers

    What is the term for the process by which lost tissue is replaced by fibrous scar tissue?

    <p>Repair</p> Signup and view all the answers

    What is the primary function of platelets in the coagulation process?

    <p>Trapped within the clot</p> Signup and view all the answers

    Which cell type is primarily responsible for removing bacteria and foreign material during the inflammatory response?

    <p>Neutrophil</p> Signup and view all the answers

    What is the role of cytokines and growth factors in the wound healing process?

    <p>Act as chemo-attractants</p> Signup and view all the answers

    Which of the following is involved in the formation of granulation tissue?

    <p>Fibroblast</p> Signup and view all the answers

    What is the primary function of prostaglandins and leukotrienes during the inflammatory response?

    <p>Vasodilation</p> Signup and view all the answers

    Which cell type is responsible for the synthesis of matrix proteins during the proliferation phase of wound healing?

    <p>Fibroblast</p> Signup and view all the answers

    What is the primary function of histamine during the inflammatory response?

    <p>Vasodilation</p> Signup and view all the answers

    What is the primary function of endothelial cells in granulation tissue?

    <p>Nutrition and blood vessel formation</p> Signup and view all the answers

    What is the term for the process by which the wound is closed by means of mechanical closure, such as sutures?

    <p>Primary intention</p> Signup and view all the answers

    What is the primary function of proteases in the remodelling phase of wound healing?

    <p>Breakdown of collagen</p> Signup and view all the answers

    What is the characteristic of granulation tissue that gives it its name?

    <p>Its granular appearance</p> Signup and view all the answers

    What is the primary difference between primary and secondary intention wound healing?

    <p>The method of closure</p> Signup and view all the answers

    What is the role of fibroblasts in the granulation tissue during wound healing?

    <p>Collagen production</p> Signup and view all the answers

    At what stage of wound healing does re-epithelialisation occur?

    <p>Proliferation phase</p> Signup and view all the answers

    What is the primary function of keratinocytes in wound healing?

    <p>Re-epithelialisation</p> Signup and view all the answers

    What is the percentage of wound strength achieved at 2-3 months after injury?

    <p>70-80%</p> Signup and view all the answers

    What is the primary function of macrophages in the granulation tissue during wound healing?

    <p>Phagocytosis and secretion</p> Signup and view all the answers

    What determines whether tissue regeneration or repair occurs in wound healing?

    <p>Amount of tissue lost and cell type</p> Signup and view all the answers

    What is the main reason why oral wounds tend to heal faster and with less scarring?

    <p>Higher concentration of growth factors in saliva</p> Signup and view all the answers

    Which of the following is NOT a factor that can delay wound healing?

    <p>High oxygen tension</p> Signup and view all the answers

    What is the primary goal of the haemostasis phase of wound healing?

    <p>To stop bleeding</p> Signup and view all the answers

    Which of the following types of wound healing is characterized by the edges of the wound being closed primarily?

    <p>Primary intention</p> Signup and view all the answers

    What is the main difference between primary and secondary intention wound healing?

    <p>Type of wound closure</p> Signup and view all the answers

    Which of the following is a key difference between skin and oral wound healing?

    <p>Greater scarring potential in skin wounds</p> Signup and view all the answers

    What is the primary mechanism by which saliva enhances oral wound healing?

    <p>Enhanced migration and proliferation of epithelial cells</p> Signup and view all the answers

    What is the primary cause of chronic wounds?

    <p>All of the above</p> Signup and view all the answers

    What is the primary purpose of hyperbaric oxygen therapy in wound care?

    <p>To improve oxygenation and reduce bacterial growth</p> Signup and view all the answers

    What is the primary function of keratinocytes in wound healing?

    <p>To migrate and proliferate to cover the wound surface</p> Signup and view all the answers

    What is the primary difference between oral and skin wounds?

    <p>Oral wounds have a more diverse microbiome</p> Signup and view all the answers

    What is the primary consequence of scarring?

    <p>Disruption of normal skin architecture and function</p> Signup and view all the answers

    What is the primary role of recombinant growth factors in wound care?

    <p>To recruit cells to the wound site and promote healing</p> Signup and view all the answers

    What is the primary mechanism by which platelets are trapped within the clot during the coagulation phase of wound healing?

    <p>Fibrin and fibrinogen glue</p> Signup and view all the answers

    What is the main function of cytokines and growth factors during the inflammatory response in wound healing?

    <p>To act as chemo-attractants for neutrophils and macrophages</p> Signup and view all the answers

    During which phase of wound healing do fibroblasts migrate and become myofibroblasts, leading to the synthesis of matrix proteins?

    <p>Proliferation phase</p> Signup and view all the answers

    What is the primary function of prostaglandins, leukotrienes, and histamine during the inflammatory response in wound healing?

    <p>To cause vasodilation</p> Signup and view all the answers

    Which type of cell is primarily responsible for phagocytosis and removal of bacteria and foreign material during the inflammatory response?

    <p>Neutrophils</p> Signup and view all the answers

    What is the primary function of platelets during the coagulation phase of wound healing?

    <p>To form a platelet plug</p> Signup and view all the answers

    What is the primary characteristic of granulation tissue that gives it its name?

    <p>Rich blood supply</p> Signup and view all the answers

    What is the primary purpose of the granulation tissue in wound healing?

    <p>To provide a framework for cellular migration and differentiation</p> Signup and view all the answers

    What is the primary difference between primary and secondary intention wound healing?

    <p>The method of wound closure and tissue apposition</p> Signup and view all the answers

    What is the role of proteases during the remodelling phase of wound healing?

    <p>To degrade and reorganise the provisional matrix</p> Signup and view all the answers

    What is the primary mechanism by which wound contraction occurs?

    <p>Through the contraction of fibroblasts and myofibroblasts</p> Signup and view all the answers

    What is the primary factor that determines the strength of the wound during the remodelling phase?

    <p>The cross-linking of collagen fibres</p> Signup and view all the answers

    What is the primary characteristic of granulation tissue that gives it its name?

    <p>Its red colour due to high capillary density</p> Signup and view all the answers

    What is the primary function of macrophages in the granulation tissue during wound healing?

    <p>To phagocytose debris and secrete growth factors</p> Signup and view all the answers

    What is the primary difference between the proliferative phase and the remodelling phase of wound healing?

    <p>The primary mechanism of tissue repair during each phase</p> Signup and view all the answers

    What is the primary function of fibroblasts in the granulation tissue during wound healing?

    <p>To synthesise new collagen fibres</p> Signup and view all the answers

    What is the primary purpose of re-epithelialisation during the proliferative phase of wound healing?

    <p>To provide a barrier against bacterial infection and promote wound closure</p> Signup and view all the answers

    What is the primary determinant of whether tissue regeneration or repair occurs in wound healing?

    <p>Cell type and amount of tissue lost</p> Signup and view all the answers

    Which of the following is a characteristic of wound healing through repair?

    <p>Lost tissue is replaced with fibrous scar</p> Signup and view all the answers

    What is the primary purpose of the haemostasis phase of wound healing?

    <p>To activate the coagulation cascade</p> Signup and view all the answers

    Which of the following is a factor that can delay wound healing?

    <p>Inadequate blood supply</p> Signup and view all the answers

    What is the primary difference between primary and secondary intention wound healing?

    <p>Primary intention wounds are closed surgically</p> Signup and view all the answers

    What is the primary function of fibroblasts during the proliferative phase of wound healing?

    <p>To synthesize matrix proteins</p> Signup and view all the answers

    Which of the following is a characteristic of chronic wounds?

    <p>They are characterized by delayed healing</p> Signup and view all the answers

    What is the primary mechanism by which collagen matrix is rearranged to form a stronger and more organized tissue during the remodelling phase of wound healing?

    <p>Proteolysis</p> Signup and view all the answers

    Which growth factor is responsible for the migration and proliferation of epithelial cells in oral wound healing?

    <p>Keratinocyte growth factor-2</p> Signup and view all the answers

    What is the primary difference between a hypertrophic scar and a keloid?

    <p>Elevated levels of growth factors</p> Signup and view all the answers

    What is the primary mechanism by which chronic wounds become 'stuck' in the inflammatory phase?

    <p>All of the above</p> Signup and view all the answers

    What is the primary role of saliva in oral wound healing?

    <p>All of the above</p> Signup and view all the answers

    Which factor is not a local factor affecting wound healing?

    <p>Age of the patient</p> Signup and view all the answers

    What is the primary mechanism by which maggot therapy enhances wound healing?

    <p>Debridement of necrotic tissue</p> Signup and view all the answers

    What is the primary function of fibroblasts in the granulation tissue during wound healing?

    <p>To synthesize collagen and mediate tissue repair</p> Signup and view all the answers

    What is the primary mechanism by which wound contraction occurs?

    <p>Through the action of fibroblasts and myofibroblasts</p> Signup and view all the answers

    What is the primary characteristic of granulation tissue that gives it its name?

    <p>Its pink color due to the presence of blood vessels</p> Signup and view all the answers

    What is the primary function of endothelial cells in granulation tissue?

    <p>To form new blood vessels and promote angiogenesis</p> Signup and view all the answers

    What is the primary purpose of re-epithelialization during the proliferative phase of wound healing?

    <p>To restore the skin's barrier function</p> Signup and view all the answers

    What is the primary factor that determines whether wound healing proceeds through regeneration or repair?

    <p>The type of tissue injured</p> Signup and view all the answers

    What is the primary consequence of delayed wound healing?

    <p>Increased risk of infection</p> Signup and view all the answers

    What is the primary function of proteases in the remodelling phase of wound healing?

    <p>To break down and remodel the provisional matrix</p> Signup and view all the answers

    What is the primary difference between primary and secondary intention wound healing?

    <p>The method of wound closure</p> Signup and view all the answers

    What is the primary characteristic of chronic wounds?

    <p>They fail to progress through the normal stages of wound healing</p> Signup and view all the answers

    Which of the following cells is primarily responsible for synthesizing matrix proteins during the proliferation phase of wound healing?

    <p>Fibroblast</p> Signup and view all the answers

    What is the primary function of cytokines and growth factors released during the inflammatory response?

    <p>Act as chemo-attractants for neutrophils</p> Signup and view all the answers

    What is the primary mechanism by which thrombus formation occurs during the coagulation phase of wound healing?

    <p>Fibrin and fibrinogen glue wound together</p> Signup and view all the answers

    Which of the following is NOT a key cell involved in the early inflammatory response?

    <p>Fibroblast</p> Signup and view all the answers

    What is the primary function of vasodilation during the inflammatory response?

    <p>Increase blood flow to the wound site</p> Signup and view all the answers

    Which of the following growth factors is involved in the recruitment of cells to the wound site during the proliferation phase?

    <p>PDGF</p> Signup and view all the answers

    What is the primary characteristic of granulation tissue that gives it its name?

    <p>Highly vascularized</p> Signup and view all the answers

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