Wound Healing Process

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What is the primary function of neutrophils in the inflammatory response?

To release cytokines and growth factors

To form a thrombus

To synthesize matrix proteins

To remove bacteria and foreign material through phagocytosis (correct)

Which of the following growth factors is involved in the recruitment of cells to the wound site?

Leukotrienes

PDGF (correct)

TGFβ

Prostaglandins

What is the primary difference between regeneration and repair in wound healing?

Regeneration is a response to minor wounds, whereas repair is a response to major wounds.

Regeneration involves a faster healing process, whereas repair involves a slower healing process.

Regeneration replaces lost tissue with the same type, whereas repair replaces lost tissue with fibrous scar tissue. (correct)

Regeneration occurs in skin wounds, whereas repair occurs in bone wounds.

What is the main purpose of the haemostasis phase in wound healing?

To stop bleeding and promote vasoconstriction. Signup and view all the answers

What is the primary function of platelets in the coagulation process?

To form a thrombus Signup and view all the answers

What is the main reason why oral wounds heal faster and without scarring?

The oral environment is more conducive to wound healing due to the presence of saliva and other factors. Signup and view all the answers

Which of the following is NOT a key cell involved in the inflammatory response?

Fibroblast Signup and view all the answers

What is the primary factor that determines whether wound healing proceeds through regeneration or repair?

All of the above. Signup and view all the answers

What is the primary function of macrophages in the inflammatory response?

To remove bacteria and foreign material through phagocytosis Signup and view all the answers

What is the primary consequence of delayed wound healing?

All of the above. Signup and view all the answers

Which of the following is involved in the vasodilation response during inflammation?

Histamine Signup and view all the answers

What is the primary goal of wound healing?

To restore tissue integrity and function. Signup and view all the answers

What is the primary function of fibroblasts in the proliferation phase of wound healing?

To synthesize matrix proteins Signup and view all the answers

What is the primary reason why wound healing is a major concern in healthcare systems?

The high cost of wound care and management. Signup and view all the answers

What is a characteristic of chronic wounds?

Accumulation of pro-inflammatory signals & macrophages Signup and view all the answers

Which of the following is NOT a factor affecting wound healing?

Genetic predisposition Signup and view all the answers

What is the purpose of hyperbaric oxygen therapy in wound care?

To promote angiogenesis Signup and view all the answers

What is the main difference in wound healing between oral and skin wounds?

Oral wounds heal quicker than skin wounds Signup and view all the answers

What is the role of saliva in oral wound healing?

Saliva is antibacterial and increases clotting time Signup and view all the answers

What is the purpose of recombinant growth factors in wound care?

To promote angiogenesis Signup and view all the answers

What is a characteristic of hypertrophic scars?

A macroscopic disturbance of the normal structure and function of the skin architecture Signup and view all the answers

Which type of collagen is replaced by bundles of type I collagen during the remodelling phase of wound healing?

Type III Signup and view all the answers

What is the main function of macrophages in the granulation tissue during wound healing?

To phagocytose and secrete Signup and view all the answers

What is the percentage of wound strength achieved at 7-10 days after injury?

10% Signup and view all the answers

Which vitamin is essential for the cross-linking of collagen I, which provides strength to the wound?

Vitamin C Signup and view all the answers

What is the term for the process by which new blood vessels are formed during wound healing?

Angiogenesis Signup and view all the answers

Which type of wound healing is characterized by the edges of the wound being apposed and held in place by mechanical means?

Primary intention Signup and view all the answers

What is the term for the process by which the provisional matrix is rearranged to form a stronger and more organized tissue during wound healing?

Remodelling Signup and view all the answers

What is the main function of fibroblasts in the granulation tissue during wound healing?

To produce collagen Signup and view all the answers

At what stage of wound healing does type I collagen become the dominant collagen type?

Remodelling Signup and view all the answers

What is the term for the process by which the wound is closed naturally by means of granulation and contraction?

Secondary intention Signup and view all the answers

What is the primary reason for delayed bone healing?

All of the above Signup and view all the answers

Which factor can negatively impact wound healing?

Steroids Signup and view all the answers

What is a characteristic of chronic wounds?

Accumulation of pro-inflammatory signals Signup and view all the answers

What is the purpose of hyperbaric oxygen therapy in wound care?

To increase oxygen delivery to the wound Signup and view all the answers

What is the primary difference between oral and skin wound healing?

Oral wounds heal faster and with less scarring Signup and view all the answers

What determines whether wound healing proceeds through regeneration or repair?

Cell type and tissue architecture Signup and view all the answers

What is the primary function of maggot therapy in wound care?

To promote debridement Signup and view all the answers

What is the main difference between wound healing in oral and skin wounds?

Oral wounds heal faster due to better blood supply Signup and view all the answers

What is the primary difference between primary and secondary intention?

Primary intention involves immediate closure of the wound, secondary intention involves delayed closure Signup and view all the answers

What is the primary goal of wound healing?

To restore tissue function Signup and view all the answers

What is the role of vasoconstriction in the haemostasis phase?

To decrease blood flow to the wound Signup and view all the answers

What is the primary consequence of delayed wound healing?

All of the above Signup and view all the answers

What is the main function of the coagulation cascade in wound healing?

To stop bleeding Signup and view all the answers

What is the term for the process by which lost tissue is replaced by fibrous scar tissue?

Repair Signup and view all the answers

What is the primary function of platelets in the coagulation process?

Trapped within the clot Signup and view all the answers

Which cell type is primarily responsible for removing bacteria and foreign material during the inflammatory response?

Neutrophil Signup and view all the answers

What is the role of cytokines and growth factors in the wound healing process?

Act as chemo-attractants Signup and view all the answers

Which of the following is involved in the formation of granulation tissue?

Fibroblast Signup and view all the answers

What is the primary function of prostaglandins and leukotrienes during the inflammatory response?

Vasodilation Signup and view all the answers

Which cell type is responsible for the synthesis of matrix proteins during the proliferation phase of wound healing?

Fibroblast Signup and view all the answers

What is the primary function of histamine during the inflammatory response?

Vasodilation Signup and view all the answers

What is the primary function of endothelial cells in granulation tissue?

Nutrition and blood vessel formation Signup and view all the answers

What is the term for the process by which the wound is closed by means of mechanical closure, such as sutures?

Primary intention Signup and view all the answers

What is the primary function of proteases in the remodelling phase of wound healing?

Breakdown of collagen Signup and view all the answers

What is the characteristic of granulation tissue that gives it its name?

Its granular appearance Signup and view all the answers

What is the primary difference between primary and secondary intention wound healing?

The method of closure Signup and view all the answers

What is the role of fibroblasts in the granulation tissue during wound healing?

Collagen production Signup and view all the answers

At what stage of wound healing does re-epithelialisation occur?

Proliferation phase Signup and view all the answers

What is the primary function of keratinocytes in wound healing?

Re-epithelialisation Signup and view all the answers

What is the percentage of wound strength achieved at 2-3 months after injury?

70-80% Signup and view all the answers

What is the primary function of macrophages in the granulation tissue during wound healing?

Phagocytosis and secretion Signup and view all the answers

What determines whether tissue regeneration or repair occurs in wound healing?

Amount of tissue lost and cell type Signup and view all the answers

What is the main reason why oral wounds tend to heal faster and with less scarring?

Higher concentration of growth factors in saliva Signup and view all the answers

Which of the following is NOT a factor that can delay wound healing?

High oxygen tension Signup and view all the answers

What is the primary goal of the haemostasis phase of wound healing?

To stop bleeding Signup and view all the answers

Which of the following types of wound healing is characterized by the edges of the wound being closed primarily?

Primary intention Signup and view all the answers

What is the main difference between primary and secondary intention wound healing?

Type of wound closure Signup and view all the answers

Which of the following is a key difference between skin and oral wound healing?

Greater scarring potential in skin wounds Signup and view all the answers

What is the primary mechanism by which saliva enhances oral wound healing?

Enhanced migration and proliferation of epithelial cells Signup and view all the answers

What is the primary cause of chronic wounds?

All of the above Signup and view all the answers

What is the primary purpose of hyperbaric oxygen therapy in wound care?

To improve oxygenation and reduce bacterial growth Signup and view all the answers

What is the primary function of keratinocytes in wound healing?

To migrate and proliferate to cover the wound surface Signup and view all the answers

What is the primary difference between oral and skin wounds?

Oral wounds have a more diverse microbiome Signup and view all the answers

What is the primary consequence of scarring?

Disruption of normal skin architecture and function Signup and view all the answers

What is the primary role of recombinant growth factors in wound care?

To recruit cells to the wound site and promote healing Signup and view all the answers

What is the primary mechanism by which platelets are trapped within the clot during the coagulation phase of wound healing?

Fibrin and fibrinogen glue Signup and view all the answers

What is the main function of cytokines and growth factors during the inflammatory response in wound healing?

To act as chemo-attractants for neutrophils and macrophages Signup and view all the answers

During which phase of wound healing do fibroblasts migrate and become myofibroblasts, leading to the synthesis of matrix proteins?

Proliferation phase Signup and view all the answers

What is the primary function of prostaglandins, leukotrienes, and histamine during the inflammatory response in wound healing?

To cause vasodilation Signup and view all the answers

Which type of cell is primarily responsible for phagocytosis and removal of bacteria and foreign material during the inflammatory response?

Neutrophils Signup and view all the answers

What is the primary function of platelets during the coagulation phase of wound healing?

To form a platelet plug Signup and view all the answers

What is the primary characteristic of granulation tissue that gives it its name?

Rich blood supply Signup and view all the answers

What is the primary purpose of the granulation tissue in wound healing?

To provide a framework for cellular migration and differentiation Signup and view all the answers

What is the primary difference between primary and secondary intention wound healing?

The method of wound closure and tissue apposition Signup and view all the answers

What is the role of proteases during the remodelling phase of wound healing?

To degrade and reorganise the provisional matrix Signup and view all the answers

What is the primary mechanism by which wound contraction occurs?

Through the contraction of fibroblasts and myofibroblasts Signup and view all the answers

What is the primary factor that determines the strength of the wound during the remodelling phase?

The cross-linking of collagen fibres Signup and view all the answers

What is the primary characteristic of granulation tissue that gives it its name?

Its red colour due to high capillary density Signup and view all the answers

What is the primary function of macrophages in the granulation tissue during wound healing?

To phagocytose debris and secrete growth factors Signup and view all the answers

What is the primary difference between the proliferative phase and the remodelling phase of wound healing?

The primary mechanism of tissue repair during each phase Signup and view all the answers

What is the primary function of fibroblasts in the granulation tissue during wound healing?

To synthesise new collagen fibres Signup and view all the answers

What is the primary purpose of re-epithelialisation during the proliferative phase of wound healing?

To provide a barrier against bacterial infection and promote wound closure Signup and view all the answers

What is the primary determinant of whether tissue regeneration or repair occurs in wound healing?

Cell type and amount of tissue lost Signup and view all the answers

Which of the following is a characteristic of wound healing through repair?

Lost tissue is replaced with fibrous scar Signup and view all the answers

What is the primary purpose of the haemostasis phase of wound healing?

To activate the coagulation cascade Signup and view all the answers

Which of the following is a factor that can delay wound healing?

Inadequate blood supply Signup and view all the answers

What is the primary difference between primary and secondary intention wound healing?

Primary intention wounds are closed surgically Signup and view all the answers

What is the primary function of fibroblasts during the proliferative phase of wound healing?

To synthesize matrix proteins Signup and view all the answers

Which of the following is a characteristic of chronic wounds?

They are characterized by delayed healing Signup and view all the answers

What is the primary mechanism by which collagen matrix is rearranged to form a stronger and more organized tissue during the remodelling phase of wound healing?

Proteolysis Signup and view all the answers

Which growth factor is responsible for the migration and proliferation of epithelial cells in oral wound healing?

Keratinocyte growth factor-2 Signup and view all the answers

What is the primary difference between a hypertrophic scar and a keloid?

Elevated levels of growth factors Signup and view all the answers

What is the primary mechanism by which chronic wounds become 'stuck' in the inflammatory phase?

All of the above Signup and view all the answers

What is the primary role of saliva in oral wound healing?

All of the above Signup and view all the answers

Which factor is not a local factor affecting wound healing?

Age of the patient Signup and view all the answers

What is the primary mechanism by which maggot therapy enhances wound healing?

Debridement of necrotic tissue Signup and view all the answers

What is the primary function of fibroblasts in the granulation tissue during wound healing?

To synthesize collagen and mediate tissue repair Signup and view all the answers

What is the primary mechanism by which wound contraction occurs?

Through the action of fibroblasts and myofibroblasts Signup and view all the answers

What is the primary characteristic of granulation tissue that gives it its name?

Its pink color due to the presence of blood vessels Signup and view all the answers

What is the primary function of endothelial cells in granulation tissue?

To form new blood vessels and promote angiogenesis Signup and view all the answers

What is the primary purpose of re-epithelialization during the proliferative phase of wound healing?

To restore the skin's barrier function Signup and view all the answers

What is the primary factor that determines whether wound healing proceeds through regeneration or repair?

The type of tissue injured Signup and view all the answers

What is the primary consequence of delayed wound healing?

Increased risk of infection Signup and view all the answers

What is the primary function of proteases in the remodelling phase of wound healing?

To break down and remodel the provisional matrix Signup and view all the answers

What is the primary difference between primary and secondary intention wound healing?

The method of wound closure Signup and view all the answers

What is the primary characteristic of chronic wounds?

They fail to progress through the normal stages of wound healing Signup and view all the answers

Which of the following cells is primarily responsible for synthesizing matrix proteins during the proliferation phase of wound healing?

Fibroblast Signup and view all the answers

What is the primary function of cytokines and growth factors released during the inflammatory response?

Act as chemo-attractants for neutrophils Signup and view all the answers

What is the primary mechanism by which thrombus formation occurs during the coagulation phase of wound healing?

Fibrin and fibrinogen glue wound together Signup and view all the answers

Which of the following is NOT a key cell involved in the early inflammatory response?

Fibroblast Signup and view all the answers

What is the primary function of vasodilation during the inflammatory response?

Increase blood flow to the wound site Signup and view all the answers

Which of the following growth factors is involved in the recruitment of cells to the wound site during the proliferation phase?

PDGF Signup and view all the answers

What is the primary characteristic of granulation tissue that gives it its name?

Highly vascularized Signup and view all the answers

Wound Healing Process

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Questions and Answers

What is the primary function of neutrophils in the inflammatory response?

Which of the following growth factors is involved in the recruitment of cells to the wound site?

What is the primary difference between regeneration and repair in wound healing?

What is the main purpose of the haemostasis phase in wound healing?

What is the primary function of platelets in the coagulation process?

What is the main reason why oral wounds heal faster and without scarring?

Which of the following is NOT a key cell involved in the inflammatory response?

What is the primary factor that determines whether wound healing proceeds through regeneration or repair?

What is the primary function of macrophages in the inflammatory response?

What is the primary consequence of delayed wound healing?

Which of the following is involved in the vasodilation response during inflammation?

What is the primary goal of wound healing?

What is the primary function of fibroblasts in the proliferation phase of wound healing?

What is the primary reason why wound healing is a major concern in healthcare systems?

What is a characteristic of chronic wounds?

Which of the following is NOT a factor affecting wound healing?

What is the purpose of hyperbaric oxygen therapy in wound care?

What is the main difference in wound healing between oral and skin wounds?

What is the role of saliva in oral wound healing?

What is the purpose of recombinant growth factors in wound care?

What is a characteristic of hypertrophic scars?

Which type of collagen is replaced by bundles of type I collagen during the remodelling phase of wound healing?

What is the main function of macrophages in the granulation tissue during wound healing?

What is the percentage of wound strength achieved at 7-10 days after injury?

Which vitamin is essential for the cross-linking of collagen I, which provides strength to the wound?

What is the term for the process by which new blood vessels are formed during wound healing?

Which type of wound healing is characterized by the edges of the wound being apposed and held in place by mechanical means?

What is the term for the process by which the provisional matrix is rearranged to form a stronger and more organized tissue during wound healing?

What is the main function of fibroblasts in the granulation tissue during wound healing?

At what stage of wound healing does type I collagen become the dominant collagen type?

What is the term for the process by which the wound is closed naturally by means of granulation and contraction?

What is the primary reason for delayed bone healing?

Which factor can negatively impact wound healing?

What is a characteristic of chronic wounds?

What is the purpose of hyperbaric oxygen therapy in wound care?

What is the primary difference between oral and skin wound healing?

What determines whether wound healing proceeds through regeneration or repair?

What is the primary function of maggot therapy in wound care?

What is the main difference between wound healing in oral and skin wounds?

What is the primary difference between primary and secondary intention?

What is the primary goal of wound healing?

What is the role of vasoconstriction in the haemostasis phase?

What is the primary consequence of delayed wound healing?

What is the main function of the coagulation cascade in wound healing?

What is the term for the process by which lost tissue is replaced by fibrous scar tissue?

What is the primary function of platelets in the coagulation process?

Which cell type is primarily responsible for removing bacteria and foreign material during the inflammatory response?

What is the role of cytokines and growth factors in the wound healing process?

Which of the following is involved in the formation of granulation tissue?

What is the primary function of prostaglandins and leukotrienes during the inflammatory response?

Which cell type is responsible for the synthesis of matrix proteins during the proliferation phase of wound healing?

What is the primary function of histamine during the inflammatory response?

What is the primary function of endothelial cells in granulation tissue?

What is the term for the process by which the wound is closed by means of mechanical closure, such as sutures?

What is the primary function of proteases in the remodelling phase of wound healing?

What is the characteristic of granulation tissue that gives it its name?

What is the primary difference between primary and secondary intention wound healing?

What is the role of fibroblasts in the granulation tissue during wound healing?

At what stage of wound healing does re-epithelialisation occur?

What is the primary function of keratinocytes in wound healing?

What is the percentage of wound strength achieved at 2-3 months after injury?

What is the primary function of macrophages in the granulation tissue during wound healing?

What determines whether tissue regeneration or repair occurs in wound healing?

What is the main reason why oral wounds tend to heal faster and with less scarring?

Which of the following is NOT a factor that can delay wound healing?

What is the primary goal of the haemostasis phase of wound healing?

Which of the following types of wound healing is characterized by the edges of the wound being closed primarily?

What is the main difference between primary and secondary intention wound healing?

Which of the following is a key difference between skin and oral wound healing?

What is the primary mechanism by which saliva enhances oral wound healing?

What is the primary cause of chronic wounds?

What is the primary purpose of hyperbaric oxygen therapy in wound care?

What is the primary function of keratinocytes in wound healing?

What is the primary difference between oral and skin wounds?

What is the primary consequence of scarring?

What is the primary role of recombinant growth factors in wound care?

What is the primary mechanism by which platelets are trapped within the clot during the coagulation phase of wound healing?