Wound Healing and Chronic Inflammation
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Questions and Answers

What is the primary difference between regeneration and repair in wound healing?

  • Regeneration is faster than repair
  • Regeneration replaces lost tissue with the same type, while repair replaces lost tissue with fibrous scar (correct)
  • Regeneration occurs in simple tissue architecture, while repair occurs in complex tissue architecture
  • Regeneration occurs in labile cells, while repair occurs in stable cells

    • What is the main purpose of the coagulation cascade in the haemostasis phase of wound healing?

  • To stop bleeding and promote clotting (correct)
  • To stimulate the inflammatory response
  • To promote cell division and proliferation
  • To remodel the tissue architecture

    • What determines the type of wound healing that occurs, whether it's regeneration or repair?

  • The presence of inflammation
  • The type of cell involved
  • The tissue architecture and amount of tissue lost (correct)
  • The amount of tissue lost

    • What is the financial impact of wound healing on healthcare systems?

    <p>It has a huge financial burden</p> Signup and view all the answers

    What is the main difference between labile, stable, and permanent cells in wound healing?

    <p>Labile cells divide continuously, stable cells divide infrequently, and permanent cells cannot divide</p> Signup and view all the answers

    What is the consequence of delayed wound healing?

    <p>Chronic wounds and scarring</p> Signup and view all the answers

    What is the primary reason why oral wounds heal faster and without scarring?

    <p>The unique tissue architecture of the oral cavity</p> Signup and view all the answers

    What is the primary function of platelets in the process of thrombus formation?

    <p>Trapping themselves within the clot to stabilize it</p> Signup and view all the answers

    Which of the following is NOT a role of neutrophils in the inflammatory response?

    <p>Proliferating locally to increase their numbers</p> Signup and view all the answers

    What is the primary function of macrophages in the inflammatory response?

    <p>Phagocytosing remaining debris and secreting cytokines and growth factors</p> Signup and view all the answers

    What is the function of prostaglandins, leukotrienes, and histamine in the inflammatory response?

    <p>Causing vasodilation and increasing blood flow to the affected area</p> Signup and view all the answers

    What is the primary function of fibroblasts in the process of granulation tissue formation?

    <p>Proliferating, migrating, and synthesizing matrix proteins</p> Signup and view all the answers

    What is the role of PDGF and TGFβ in the inflammatory response?

    <p>Acting as chemo-attractants to recruit immune cells</p> Signup and view all the answers

    What is the primary function of cytokines and growth factors released during the inflammatory response?

    <p>Acting as chemo-attractants to recruit immune cells</p> Signup and view all the answers

    What is the primary function of macrophages in the repair process?

    <p>Phagocytosis and secretion</p> Signup and view all the answers

    What type of collagen is initially formed during the repair process?

    <p>Type III collagen</p> Signup and view all the answers

    What is the role of proteases in the remodelling phase?

    <p>To break down provisional matrix</p> Signup and view all the answers

    What is the approximate percentage of wound strength at 7-10 days post-injury?

    <p>10%</p> Signup and view all the answers

    What is the term for the type of wound healing where the wound is left open and allowed to close naturally?

    <p>Secondary intention</p> Signup and view all the answers

    What is the primary component of granulation tissue that gives it its characteristic appearance?

    <p>Macrophages and matrix</p> Signup and view all the answers

    What is the term for the process by which the wound contracts and closes?

    <p>Wound contraction</p> Signup and view all the answers

    What is the primary reason for chronic wounds getting 'stuck' in the inflammatory phase?

    <p>Accumulation of pro-inflammatory signals and macrophages</p> Signup and view all the answers

    What is the main difference in the phenotype of cells between oral and skin wounds?

    <p>Enhanced migration and proliferation of epithelial cells</p> Signup and view all the answers

    What is the main function of maggot therapy in wound healing?

    <p>To debride the wound and stimulate healing</p> Signup and view all the answers

    What is the primary role of osteoclasts in tooth socket healing?

    <p>Bone resorption</p> Signup and view all the answers

    What is the main characteristic of hypertrophic scars?

    <p>A macroscopic disturbance of the normal structure and function of the skin architecture</p> Signup and view all the answers

    What is the main reason for the difference in healing between oral and skin wounds?

    <p>All of the above</p> Signup and view all the answers

    What is the primary function of recombinant growth factors in wound healing?

    <p>To stimulate cell migration and proliferation</p> Signup and view all the answers

    What is the primary role of matrix materials in wound healing?

    <p>To provide a scaffold for tissue regeneration</p> Signup and view all the answers

    What is the primary cause of scarring in wounds?

    <p>Abnormal collagen deposition</p> Signup and view all the answers

    What is the primary benefit of negative pressure/vacuum therapy in wound healing?

    <p>To enhance wound contraction and closure</p> Signup and view all the answers

    What is the primary reason why wound healing is considered an essential process?

    <p>It attempts to restore tissue integrity following injury, trauma, or surgery</p> Signup and view all the answers

    What determines whether wound healing proceeds through regeneration or repair?

    <p>Amount of tissue lost and cell type</p> Signup and view all the answers

    During the haemostasis phase of wound healing, what occurs within 5-10 minutes?

    <p>Vasoconstriction</p> Signup and view all the answers

    What is the primary difference between labile, stable, and permanent cells in wound healing?

    <p>Their ability to divide</p> Signup and view all the answers

    Why is wound healing a huge financial burden to healthcare systems?

    <p>Wound healing can lead to chronic wounds</p> Signup and view all the answers

    What is the primary difference between primary and secondary intention in wound healing?

    <p>Healing by first intention involves immediate closure, while healing by second intention involves delayed closure</p> Signup and view all the answers

    Why do oral wounds heal faster and without scarring compared to skin wounds?

    <p>Oral wounds have a unique tissue architecture</p> Signup and view all the answers

    What is the primary function of endothelial cells in granulation tissue?

    <p>Nutrition and blood vessel formation</p> Signup and view all the answers

    What is the primary function of platelets in the haemostasis phase of wound healing?

    <p>Form a clot to stop bleeding</p> Signup and view all the answers

    What is the primary component of granulation tissue responsible for its characteristic appearance?

    <p>Endothelial cells and blood vessels</p> Signup and view all the answers

    What is the primary purpose of proteases in the remodelling phase of wound healing?

    <p>Breaking down collagen type III</p> Signup and view all the answers

    What is the primary function of prostaglandins, leukotrienes, and histamine in the inflammatory response?

    <p>Promote vasodilation and increase blood flow</p> Signup and view all the answers

    What is the approximate percentage of wound strength at 2-3 months post-injury?

    <p>70-80%</p> Signup and view all the answers

    What is the primary function of macrophages in the inflammatory response?

    <p>Remove bacteria and foreign material through phagocytosis</p> Signup and view all the answers

    What is the primary function of fibroblasts in the process of granulation tissue formation?

    <p>Proliferate and migrate to form granulation tissue</p> Signup and view all the answers

    What is the term for the type of wound healing where the wound edges are apposed and held in place by mechanical means?

    <p>Primary intention</p> Signup and view all the answers

    What is the primary function of PDGF and TGFβ in the inflammatory response?

    <p>Stimulate the proliferation of fibroblasts</p> Signup and view all the answers

    What is the role of Vitamin C in wound healing?

    <p>Promoting collagen synthesis</p> Signup and view all the answers

    What is the primary mechanism by which wounds contract and close?

    <p>Fibroblast contraction</p> Signup and view all the answers

    What is the primary function of cytokines and growth factors released during the inflammatory response?

    <p>Stimulate the proliferation of fibroblasts</p> Signup and view all the answers

    What is the primary characteristic of granulation tissue that gives it its characteristic appearance?

    <p>High density of blood vessels</p> Signup and view all the answers

    What is the primary reason why wounds with larger tissue loss are more likely to scar?

    <p>Because the wound is more likely to get stuck in the inflammatory phase</p> Signup and view all the answers

    What is the primary function of saliva in oral wound healing?

    <p>To increase the clotting time and provide a moist environment</p> Signup and view all the answers

    What is the primary difference between the immune response in oral and skin wounds?

    <p>The immune response is more rapid and quickly resolved in oral wounds</p> Signup and view all the answers

    What is the primary role of collagen in the remodelling phase of wound healing?

    <p>To provide a scaffold for the growth of new tissue</p> Signup and view all the answers

    What is the primary reason why chronic wounds are characterized by an accumulation of pro-inflammatory signals and macrophages?

    <p>Due to the failure of the wound to progress to the proliferative phase</p> Signup and view all the answers

    What is the primary function of EGF, KGF-2, and PDGF in wound healing?

    <p>To promote the growth of new tissue</p> Signup and view all the answers

    What is the primary reason why wounds with poor blood supply are more prone to scarring?

    <p>Due to the impaired delivery of oxygen and nutrients</p> Signup and view all the answers

    What is the primary function of hyperbaric oxygen therapy in wound healing?

    <p>To enhance the delivery of oxygen to the wound site</p> Signup and view all the answers

    What is the primary difference between keloids and hypertrophic scars?

    <p>Keloids are smaller and more raised than hypertrophic scars</p> Signup and view all the answers

    What is the primary role of the microbiome in oral wound healing?

    <p>To increase the diversity of PAMPs</p> Signup and view all the answers

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