Viral Host Range Determination Technologies

What is the main purpose of attachment and entry in the infectious cycle of a virus?

To allow the virus to enter the host cell

What defines a susceptible cell in virology terms?

A cell that can support viral replication

What technology advancement allowed the determination of viral receptors?

Flow cytometry

Why are viruses considered obligate intracellular parasites?

Because they require host cells to replicate Signup and view all the answers

Which of the following is a criteria for a genuine virus receptor?

Disruption of the receptor gene should enhance infection Signup and view all the answers

What is the first step in the attachment process of a virus to a host cell?

Random collisions and electrostatic interactions Signup and view all the answers

What role do virion cellular receptors play in the infectious cycle?

Bind the virus particle and assist in entry into the cell Signup and view all the answers

Which molecule is known as the receptor for SARS-CoV-2?

ACE2 Signup and view all the answers

What determines the host range of a virus?

Presence of host cell receptors Signup and view all the answers

What distinguishes a permissive cell from a susceptible cell in terms of virus infection?

Permissive cells can support viral replication Signup and view all the answers

Which two viruses share a common primary receptor?

Adenovirus and Coxsackievirus B3 Signup and view all the answers

How do viruses attach to receptors?

By fusing their envelope with the host cell membrane Signup and view all the answers

What specific protein does the viral fusion protein bind to in the endosome membrane?

Niemann-Pick C1 protein (NPC1-protein) Signup and view all the answers

In what condition must viral fusion not occur?

Neutral pH (plasma membrane) Signup and view all the answers

How are genomes released from non-enveloped viruses?

Uncoating at nuclear pore complex Signup and view all the answers

What is a common feature of viruses infecting plant cells?

Utilize plasmodesmata for intercellular movement Signup and view all the answers

What is the role of motor proteins in adenovirus infection?

Assist in virion transport within the host cell Signup and view all the answers

How do some viruses breach the strong cell wall of bacterial cells?

By exploiting specialized structures on the bacterial surface Signup and view all the answers