30 Questions
What is a contraindication for the use of TCAs?
Glaucoma
What is the result of the interaction between TCAs and MAOIs?
Hypertensive crisis
Which of the following is a side effect of TCAs?
Dry mouth
What is the effect of aspirin on TCAs?
Potentiates the effect of TCAs
What is the effect of barbiturates on TCAs?
Reduces the effect of TCAs
Why should TCAs not be used with SSRIs?
Because SSRIs inhibit the metabolism of TCAs
What is the characteristic of 75% of unipolar depression cases?
They are accompanied by symptoms of anxiety and agitation
Which type of depression is associated with suicidal thoughts?
Severe depression
What is the main difference between unipolar and bipolar depression?
Unipolar only involves depression, while bipolar involves both depression and mania
According to the Monoamine Theory of Depression, what is the cause of depression?
A functional deficit of monoamine transmitters
What is the name of the hypothesis that suggests depression is associated with insufficient central release of NA and 5-HT?
The Biogenic Amine Hypothesis
What is the effect of Reserpine on the brain, according to the Monoamine Theory of Depression?
It causes depression
What is the likely cause of an abnormal pethidine metabolite?
Inhibition of normal demethylation pathway
What is the result of the interaction between Levodopa and MAOIs?
Hypertensive crisis
What is the effect of taking tyramine rich foods with MAOIs?
Massive release of norepinephrine and hypertensive crisis
What is the minimum amount of tyramine required to produce a reaction?
10 mg
What is the resulting condition when TCAs interact with MAOIs?
Hypertensive crisis
What is the condition that occurs when MAOIs and SSRIs are taken together?
Serotonin syndrome
What is a common symptom of discontinuation syndrome related to SSRIs?
Malaise
Which of the following conditions is NOT treated by SSRIs?
Schizophrenia
What is the primary reason for not combining SSRIs with MAOIs?
Increased risk of serotonin syndrome
What is the advantage of NRIs over TCAs?
Fewer cardiovascular effects
Which of the following is a characteristic of NRIs?
Selective inhibition of norepinephrine uptake
What is the potential benefit of NRIs in depression associated with fatigue?
More effective treatment of noradrenaline deficiency syndrome
What is the effect of Bupropion on 5-HT activity?
It decreases 5-HT activity
What is a unique advantage of Bupropion compared to SSRI's?
It increases libido
What is a therapeutic use of Bupropion besides major depression?
ADHD
What is the mechanism of action of Mirtazapine?
It blocks alpha 2 auto receptor and hetero receptors
What is the effect of Duloxetine on uretheral tone?
It increases uretheral tone
What is the primary use of Bupropion in smoking cessation?
It reduces craving and attenuates withdrawal symptoms
This quiz explores the different types of depression, including mild, moderate, and severe depression, as well as unipolar and bipolar depression. Learn about the characteristics of each type, including symptoms and causes.
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