Podcast
Questions and Answers
What is the primary mode of transmission for tuberculosis?
What is the primary mode of transmission for tuberculosis?
What immune cells are responsible for engulfing and destroying Mycobacterium tuberculosis?
What immune cells are responsible for engulfing and destroying Mycobacterium tuberculosis?
What is the name of the lesions that form in the lungs as a result of the body's immune response to Mycobacterium tuberculosis?
What is the name of the lesions that form in the lungs as a result of the body's immune response to Mycobacterium tuberculosis?
Which of the following is NOT a symptom of tuberculosis?
Which of the following is NOT a symptom of tuberculosis?
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What is the recommended number of early morning sputum samples to be collected for an acid-fast bacilli (AFB) culture?
What is the recommended number of early morning sputum samples to be collected for an acid-fast bacilli (AFB) culture?
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What is the minimum size of induration considered a positive result for a Mantoux skin test in an immunocompromised patient?
What is the minimum size of induration considered a positive result for a Mantoux skin test in an immunocompromised patient?
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Which of the following diagnostic tests is a blood test used to detect Mycobacterium tuberculosis?
Which of the following diagnostic tests is a blood test used to detect Mycobacterium tuberculosis?
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Which of the following is TRUE about the BCG vaccine?
Which of the following is TRUE about the BCG vaccine?
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What is the primary reason for placing a patient with tuberculosis in a negative airflow room?
What is the primary reason for placing a patient with tuberculosis in a negative airflow room?
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Which of the following medications is NOT commonly used to treat tuberculosis?
Which of the following medications is NOT commonly used to treat tuberculosis?
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What does the mnemonic "ripe orange" represent in relation to tuberculosis treatment?
What does the mnemonic "ripe orange" represent in relation to tuberculosis treatment?
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How often should a patient with tuberculosis provide a sputum sample during their treatment?
How often should a patient with tuberculosis provide a sputum sample during their treatment?
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When is a patient with tuberculosis considered to be no longer infectious?
When is a patient with tuberculosis considered to be no longer infectious?
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Study Notes
Tuberculosis (TB) Overview
- TB is a lung infection caused by Mycobacterium tuberculosis.
- Transmission is airborne, via aerosolization, reaching the alveoli.
- Triggers an immune response, macrophage ingestion, and granuloma formation.
- Macrophages are crucial for pathogen detection and destruction.
Symptoms and Screening
- Symptoms include cough lasting >3 weeks, purulent/bloody sputum, unexplained weight loss, night sweats, and lethargy.
- These symptoms are screened for during hospital admission.
- Positive response means airborne precautions are initiated until ruled out.
Diagnostics
- QuantiFERON Gold blood test: Detects Mycobacterium tuberculosis. Simple blood test.
-
Mantoux skin test: Intradermal injection, read 48-72 hours. Induration (hardening) assessed.
- 10mm induration = positive (active/previous infection).
- 5mm induration = positive (immunocompromised).
- BCG vaccine (TB vaccine) can cause false positives.
- Acid-fast bacilli (AFB) culture: Inoculates clinical specimen for bacterial growth. Three early morning sputum samples are required.
- Chest x-ray: Checks for active lung lesions.
Treatment
- Combination drug therapy (4 antibiotics).
- Treatment duration: 6-12 months.
- Common medications include rifampin, isoniazid, pyrazinamide, and ethambutol.
- Mnemonic: "ripe orange" (first letters & rifampin effect)
Nursing Care
- Negative airflow room (airborne precautions).
- N95 masks for all room entrants.
- Surgical masks for patient movement.
- TB screening of family members.
- Regular sputum samples during therapy (until 3 negative cultures).
- Patients are no longer considered infectious after 3 negative sputum cultures.
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Description
This quiz delves into the basics of tuberculosis (TB), its transmission, and immune responses. It covers key symptoms for screening, important diagnostic tests like QuantiFERON Gold and Mantoux skin test, and their interpretations. Test your knowledge about TB's impact and management through this informative quiz.