Podcast
Questions and Answers
What type of hypersensitivity is triggered by the introduction of tuberculin in the intradermal Mantoux test?
What type of hypersensitivity is triggered by the introduction of tuberculin in the intradermal Mantoux test?
delayed-type hypersensitivity
What is the main component of tuberculin?
What is the main component of tuberculin?
a large array of mycobacterial antigens
What is the result of a positive Mantoux reaction?
What is the result of a positive Mantoux reaction?
sensibilization with non-tuberculous mycobacteria, BCG vaccination, or infection with tuberculosis Mycobacteria
What is the limitation of the Mantoux test?
What is the limitation of the Mantoux test?
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What is the risk of a positive reaction in the presence of an active tuberculosis infection?
What is the risk of a positive reaction in the presence of an active tuberculosis infection?
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What is the purpose of using tuberculin in the intradermal Mantoux test?
What is the purpose of using tuberculin in the intradermal Mantoux test?
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What type of immune reaction occurs when tuberculin is introduced into the body?
What type of immune reaction occurs when tuberculin is introduced into the body?
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What can make it difficult for doctors to interpret the results of the Mantoux test?
What can make it difficult for doctors to interpret the results of the Mantoux test?
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What can be mistaken for a post-vaccination reaction in the Mantoux test?
What can be mistaken for a post-vaccination reaction in the Mantoux test?
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What accumulates in the body as a result of primary immunization against mycobacterium tuberculosis?
What accumulates in the body as a result of primary immunization against mycobacterium tuberculosis?
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Study Notes
Mantoux Test
- The intradermal Mantoux test has been used for tuberculin diagnostics in the country for almost 100 years.
- The test uses tuberculin, a culture filtrate containing a large array of mycobacterial antigens, to determine specific sensibilization of the body to Mycobacterium tuberculosis (MBT).
Mechanism of the Mantoux Test
- Primary immunization against MBT through BCG vaccination leads to the accumulation of mature memory T-cells in the body, which store information about the antigenic properties of mycobacteria.
- The introduction of tuberculin triggers an immune reaction of the delayed-type hypersensitivity type.
- A positive Mantoux reaction develops in response to:
- BCG vaccination
- Sensibilization with non-tuberculous mycobacteria
- Infection with tuberculosis Mycobacteria
Limitations of the Mantoux Test
- Low specificity and a high percentage of false positive reactions can lead to:
- Overdiagnosis of the disease
- Unreasonable prescribing of preventive therapy
- A positive reaction may be misinterpreted as post-vaccination in the presence of active tuberculosis infection and a high risk of developing the disease.
Mantoux Test
- The intradermal Mantoux test has been used for tuberculin diagnostics in the country for almost 100 years.
- The test uses tuberculin, a culture filtrate containing a large array of mycobacterial antigens, to determine specific sensibilization of the body to Mycobacterium tuberculosis (MBT).
Mechanism of the Mantoux Test
- Primary immunization against MBT through BCG vaccination leads to the accumulation of mature memory T-cells in the body, which store information about the antigenic properties of mycobacteria.
- The introduction of tuberculin triggers an immune reaction of the delayed-type hypersensitivity type.
- A positive Mantoux reaction develops in response to:
- BCG vaccination
- Sensibilization with non-tuberculous mycobacteria
- Infection with tuberculosis Mycobacteria
Limitations of the Mantoux Test
- Low specificity and a high percentage of false positive reactions can lead to:
- Overdiagnosis of the disease
- Unreasonable prescribing of preventive therapy
- A positive reaction may be misinterpreted as post-vaccination in the presence of active tuberculosis infection and a high risk of developing the disease.
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Description
This quiz covers the basics of the Mantoux test, a diagnostic tool used to determine the presence of mycobacterial antigens in the body. It also explores the role of tuberculin and BCG vaccination in the fight against tuberculosis.
