Podcast
Questions and Answers
What is the advantage of transcription regulators forming heterodimers?
What is the advantage of transcription regulators forming heterodimers?
- To decrease affinity and specificity
- To increase affinity and specificity (correct)
- To bind to RNA instead of DNA
- To reduce the dynamic nature of DNA binding
What is the characteristic of cooperative binding of transcription regulators to DNA?
What is the characteristic of cooperative binding of transcription regulators to DNA?
- Binding is only possible at low protein concentrations
- Binding is gradual and dependent on protein concentration
- Binding is all-or-none, with the cis-regulatory sequence being either fully occupied or empty (correct)
- Binding is only possible at high protein concentrations
What is the nature of DNA binding by transcription regulators?
What is the nature of DNA binding by transcription regulators?
- Only possible at specific DNA sequences
- Dynamic, with molecules in constant motion and rapidly binding and dissociating from DNA (correct)
- Static, with molecules binding permanently to DNA
- Only possible in the presence of other proteins
What is the significance of a transcription regulator being fully bound to its cis-regulatory sequence?
What is the significance of a transcription regulator being fully bound to its cis-regulatory sequence?
How do bacteria regulate the expression of many of their genes?
How do bacteria regulate the expression of many of their genes?
What triggers the bacterium to utilize alternative sources of carbon?
What triggers the bacterium to utilize alternative sources of carbon?
What is the role of the Lac repressor in the Lac operon?
What is the role of the Lac repressor in the Lac operon?
How do transcription regulators act in eukaryotic gene regulation?
How do transcription regulators act in eukaryotic gene regulation?
What is the nature of an individual eukaryotic transcription regulator?
What is the nature of an individual eukaryotic transcription regulator?
How is an eukaryotic gene regulated?
How is an eukaryotic gene regulated?
What percentage of protein-coding genes are typically devoted to transcription regulators in most organisms?
What percentage of protein-coding genes are typically devoted to transcription regulators in most organisms?
What is the primary reason why transcription regulators bind to specific cis-regulatory sequences?
What is the primary reason why transcription regulators bind to specific cis-regulatory sequences?
Why do transcription regulators typically make the majority of their contacts with the major groove of DNA?
Why do transcription regulators typically make the majority of their contacts with the major groove of DNA?
What is the result of dimerization of transcription regulators in terms of DNA binding?
What is the result of dimerization of transcription regulators in terms of DNA binding?
What is the typical recognition site size for a monomer of a transcription regulator?
What is the typical recognition site size for a monomer of a transcription regulator?
What is the typical arrangement of genes in bacteria?
What is the typical arrangement of genes in bacteria?
What is the role of the tryptophan repressor in regulating the tryptophan operon?
What is the role of the tryptophan repressor in regulating the tryptophan operon?
How does the tryptophan repressor bind to DNA?
How does the tryptophan repressor bind to DNA?
What is the function of the Lac operon?
What is the function of the Lac operon?
What is a characteristic feature of eukaryotic gene regulation?
What is a characteristic feature of eukaryotic gene regulation?
