Thyroid Gland and Hormones Overview
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Questions and Answers

Which of the following statements about thyroid hormones is INCORRECT?

  • Thyroid hormones are essential for the normal development of the skeletal, muscular and nervous systems in children.
  • Thyroid hormones have the ability to activate genes involved in glycolysis and ATP production leading to a calorigenic effect.
  • The majority of thyroid hormones are unbound and free to diffuse into target cells' tissues. (correct)
  • Thyroid hormones are primarily transported in the bloodstream bound to proteins called thyroid-binding globulins (TBGs).
  • Which of the following best describes the role of C cells in the thyroid gland?

  • Synthesis of thyroglobulin, a protein that serves as a precursor for thyroid hormones.
  • Secretion of thyroid hormones, `T4` and `T3`, in response to `TSH` stimulation.
  • Production and secretion of calcitonin hormone, which regulates calcium levels in the body. (correct)
  • Absorption of iodine ions (`I^--^`) from the blood to produce thyroid hormones.
  • Which of the following is NOT a direct effect of thyroid hormones on the body?

  • Increased heart rate and force of contraction.
  • Stimulation of red blood cell formation.
  • Stimulation of insulin production by the pancreas. (correct)
  • Increased sensitivity to sympathetic nervous system stimulation.
  • What is the primary function of thyroid-stimulating hormone (TSH) in the thyroid gland?

    <p>Stimulation of thyroid hormone synthesis and release by promoting the iodination of thyroglobulin. (C)</p> Signup and view all the answers

    Which of the following is the most accurate description of the relationship between the thyroid gland and calcium homeostasis?

    <p>The thyroid gland indirectly regulates calcium levels through the production and release of calcitonin, influencing calcium excretion and absorption. (B)</p> Signup and view all the answers

    Which of the following correctly describes the effect of the absence of thyroid-stimulating hormone (TSH) on the thyroid gland?

    <p>The thyroid follicles become inactive, leading to cessation of both thyroid hormone synthesis and secretion. (A)</p> Signup and view all the answers

    Where are the receptors for thyroid hormones primarily located within target cells?

    <p>In the cytoplasm, on the surfaces of mitochondria, and in the nucleus. (D)</p> Signup and view all the answers

    Which of the following accurately describes the relationship between T4 and T3 in the synthesis and action of thyroid hormones?

    <p>T4 is inactive, while T3 is the primary active form responsible for the majority of thyroid hormone actions. (C)</p> Signup and view all the answers

    Which physiological process is directly influenced by the "calorigenic effect" of thyroid hormones?

    <p>Regulation of body temperature through increased metabolic rate and heat generation. (C)</p> Signup and view all the answers

    What is the primary role of the thyroid follicles in the thyroid gland?

    <p>Storage and release of thyroid hormones in a colloid-filled cavity. (B)</p> Signup and view all the answers

    Flashcards

    Thyroid Gland

    Lies below the larynx, consists of two lobes joined by isthmus.

    Thyroid Follicles

    Hollow spheres lined by cuboidal epithelium, surrounded by capillaries.

    Thyroglobulin

    Globular protein created by follicles, contains tyrosine for hormone synthesis.

    Thyroxine (T4)

    Thyroid hormone with four iodine atoms, regulates metabolism.

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    Triiodothyronine (T3)

    Thyroid hormone with three iodine atoms, more active than T4.

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    Thyroid-binding Globulins (TBGs)

    Proteins that transport thyroid hormones in blood.

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    Thyroid-stimulating Hormone (TSH)

    Hormone that activates thyroid follicles for hormone production.

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    Calorigenic Effect

    Increased energy consumption and heat generation due to thyroid hormones.

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    C Cells

    Produce calcitonin (CT) to regulate calcium levels in the blood.

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    Effects of Thyroid Hormones

    Increase metabolism, heart rate, and sensitivity to stimuli in almost every cell.

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    Study Notes

    THYROID GLAND

    • Located inferior to the thyroid cartilage of the larynx
    • Composed of two lobes connected by an isthmus
    • Thyroid Follicles: Hollow spheres lined by cuboidal epithelium, surrounded by capillaries
      • Cells absorb iodide ions from the blood
      • Follicle cavity contains colloid
      • Contains C (clear) cells, or parafollicular cells
    • Thyroglobulin: Globular protein synthesized by follicle cells, secreted into colloid, containing tyrosine (building block of thyroid hormones)
    • Thyroid Hormones:
      • Thyroxine (T4): Tetraiodothyronine, containing four iodine atoms
      • Triiodothyronine (T3): Containing three iodine atoms
    • Thyroid-binding Globulins (TBGs): Proteins binding about 75% of T4 and 70% of T3 in the bloodstream, with transthyretin and albumin binding the remainder
      • A small percentage (0.3% T3 and 0.03% T4) remains unbound and diffuses into tissues

    THYROID-STIMULATING HORMONE (TSH)

    • Absence of TSH causes thyroid follicles to become inactive, with no synthesis or secretion of hormones
    • TSH binds to plasma membrane receptors, activating enzymes for hormone production
    • Thyroid hormones affect virtually every cell in the body, entering through transport systems, binding to receptors in the cytoplasm, on mitochondria surfaces, or in the nucleus

    EFFECTS OF THYROID HORMONES

    • Increase oxygen and energy consumption, impacting body temperature
    • Increase heart rate and contraction force
    • Improve sensitivity to sympathetic stimulation
    • Maintain sensitivity of respiratory centers to oxygen/carbon dioxide
    • Stimulate red blood cell formation and endocrine tissue activity
    • Accelerate bone mineral turnover
    • Essential for normal development of skeletal, muscular, and nervous systems in children

    PARATHYROID GLANDS

    • Located on the posterior surface of the thyroid gland
    • Secrete parathyroid hormone (PTH) in response to low blood calcium levels
    • Parathyroid Hormone (PTH): Antagonist for calcitonin, acting to increase blood calcium
      • Stimulates osteoclasts, accelerating mineral turnover and calcium release
      • Enhances calcium reabsorption by kidneys, reducing urinary losses
      • Stimulates calcitriol formation and secretion by kidneys

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    Description

    Explore the anatomy and physiology of the thyroid gland, including its structure and the hormones it produces, such as thyroxine (T4) and triiodothyronine (T3). This quiz covers the key components of thyroid follicles and the role of thyroid-stimulating hormone (TSH). Test your knowledge on the functions and importance of the thyroid in the endocrine system.

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