24.6 Reabsorption and Secretion in Tubules and Collecting Ducts
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Questions and Answers

What happens to the blood concentration of plasma proteins in an individual with renal disease that results in damage to the filtration membrane?

  • The blood concentration of plasma proteins fluctuates unpredictably.
  • The blood concentration of plasma proteins increases.
  • The blood concentration of plasma proteins decreases. (correct)
  • The blood concentration of plasma proteins remains unchanged.
  • How does renal disease that decreases filtration at the filtration membrane affect the blood concentration of small plasma proteins?

  • The blood concentration of small plasma proteins fluctuates randomly.
  • The blood concentration of small plasma proteins decreases.
  • The blood concentration of small plasma proteins increases. (correct)
  • The blood concentration of small plasma proteins remains unchanged.
  • What is the term used to describe the loss of plasma proteins in the urine due to saturation of cellular structures in the kidney tubules?

  • Edema
  • Proteinuria (correct)
  • Hematuria
  • Hypoproteinemia
  • What is the potential physiologic outcome of having too low of a blood concentration of plasma proteins?

    <p>Fluid retention and edema</p> Signup and view all the answers

    What is the potential physiologic outcome of having too high of a blood concentration of plasma proteins?

    <p>Increased blood viscosity</p> Signup and view all the answers

    What is the primary mechanism by which renal disease that decreases filtration at the filtration membrane leads to an increase in the blood concentration of small plasma proteins?

    <p>Decreased filtration and degradation of small plasma proteins in the kidney tubules</p> Signup and view all the answers

    What is the primary effect of an increase in urine output?

    <p>Decreases blood volume and blood pressure</p> Signup and view all the answers

    Which of the following is NOT one of the three major variables that influence blood pressure?

    <p>Urine output</p> Signup and view all the answers

    What is the primary mechanism by which potassium is reabsorbed in the proximal convoluted tubule?

    <p>Paracellular transport</p> Signup and view all the answers

    What is the primary driving force for the reabsorption of potassium in the proximal convoluted tubule?

    <p>The movement of sodium</p> Signup and view all the answers

    Which of the following best describes the overall movement of potassium along the nephron?

    <p>Potassium is both reabsorbed and secreted</p> Signup and view all the answers

    What is the primary factor that determines the amount of potassium lost in the urine?

    <p>The activity of principal cells in the collecting tubules and ducts in response to aldosterone</p> Signup and view all the answers

    What is the primary mechanism by which water is reabsorbed in the renal tubules?

    <p>Osmosis</p> Signup and view all the answers

    Which of the following hormones decreases sodium reabsorption in the renal tubules?

    <p>Atrial natriuretic peptide</p> Signup and view all the answers

    Approximately what percentage of the water in the tubular fluid is reabsorbed in the proximal convoluted tubule?

    <p>65%</p> Signup and view all the answers

    What is the term used to describe the water reabsorption that follows sodium reabsorption in the proximal convoluted tubule?

    <p>Obligatory water reabsorption</p> Signup and view all the answers

    Which of the following statements about aquaporins is true?

    <p>They are water transport proteins found in the luminal membrane of the proximal convoluted tubule.</p> Signup and view all the answers

    What is the average amount of water excreted daily from the approximately 180 L of water filtered by the kidneys?

    <p>1.5 L</p> Signup and view all the answers

    What contributes approximately one-half of the solutes of the interstitial fluid concentration gradient?

    <p>Recycled urea</p> Signup and view all the answers

    Where is urea removed from the tubular fluid in the nephron?

    <p>Collecting duct</p> Signup and view all the answers

    Why does urea remain within the tubular fluid until it reaches the collecting duct?

    <p>Thin segment of the ascending limb is impermeable to urea</p> Signup and view all the answers

    What contributes to the concentration gradient in the interstitial fluid?

    <p>Urea cycling</p> Signup and view all the answers

    Which part of the nephron is responsible for reabsorbing a majority of substances after filtration?

    <p>Proximal convoluted tubules</p> Signup and view all the answers

    What happens as tubular fluid moves through the nephron loop?

    <p>More substances are reabsorbed</p> Signup and view all the answers

    What is the primary mode of potassium reabsorption from the tubular fluid into the blood?

    <p>Paracellular transport</p> Signup and view all the answers

    Which of the following solutes can also be passively reabsorbed along with potassium?

    <p>All of the above</p> Signup and view all the answers

    Approximately what percentage of potassium in the tubular fluid is reabsorbed in the thick ascending limb of the nephron loop?

    <p>10% to 20%</p> Signup and view all the answers

    Which of the following cell types in the collecting tubules and collecting ducts reabsorbs potassium continuously?

    <p>Intercalated cells</p> Signup and view all the answers

    What is the primary stimulant for the release of aldosterone from the adrenal cortex?

    <p>Elevated blood potassium levels</p> Signup and view all the answers

    Approximately what percentage of calcium in the blood becomes part of the filtrate and then the tubular fluid?

    <p>60%</p> Signup and view all the answers

    What happens to the blood concentration of plasma proteins in an individual with renal disease that results in higher than normal filtration of plasma proteins?

    <p>Blood concentration of all plasma proteins decreases</p> Signup and view all the answers

    What is the clinical consequence of renal disease that results in lower than normal filtration of plasma proteins?

    <p>Edema due to low plasma proteins</p> Signup and view all the answers

    What happens when renal disease results in damage to the filtration membrane?

    <p>Blood concentration of all plasma proteins decreases</p> Signup and view all the answers

    What physiologic outcome can occur when an individual has too low blood concentrations of plasma proteins?

    <p>Edema</p> Signup and view all the answers

    How does renal disease resulting in lower than normal filtration of plasma proteins affect blood concentrations?

    <p>Increases blood concentration of small plasma proteins</p> Signup and view all the answers

    What occurs when the kidney's function is altered, causing abnormal changes in the filtration of plasma proteins?

    <p>Saturation of tubular structures involved in protein uptake</p> Signup and view all the answers

    What establishes the concentration gradient of the interstitial fluid in the kidney?

    <p>The nephron loop and vasa recta</p> Signup and view all the answers

    Which cells are mainly responsible for regulating the amount of specific substances excreted in urine?

    <p>Principal cells and intercalated cells</p> Signup and view all the answers

    What is the composition of urine?

    <p>Water and various dissolved substances</p> Signup and view all the answers

    Where does the fluid leaving the collecting ducts at the renal papilla go next?

    <p>It enters the ureter for excretion.</p> Signup and view all the answers

    Under normal circumstances, why does urine not contain nutrients like glucose and proteins?

    <p>Because they are 100% reabsorbed in the distal convoluted tubule.</p> Signup and view all the answers

    What occurs in the proximal convoluted tubule, nephron loop, distal convoluted tubule, collecting tubules, and collecting ducts?

    <p>Reabsorption and secretion processes</p> Signup and view all the answers

    Which of the following is the primary source of creatinine production in the body?

    <p>Metabolism of creatine in muscle tissue</p> Signup and view all the answers

    What is the primary function of urea in the kidneys?

    <p>To establish the concentration gradient in the interstitial fluid</p> Signup and view all the answers

    What is the primary mechanism by which urea is reabsorbed in the proximal convoluted tubule?

    <p>Paracellular movement</p> Signup and view all the answers

    What percentage of the filtered urea is excreted in the urine?

    <p>50%</p> Signup and view all the answers

    Which of the following is a key difference between urea and creatinine in terms of their processing in the kidneys?

    <p>Urea is both reabsorbed and secreted, while creatinine is only secreted</p> Signup and view all the answers

    What is the primary reason for the range in normal blood urea levels?

    <p>Variation in protein intake</p> Signup and view all the answers

    What is the primary mechanism by which proteins are reabsorbed from the tubular fluid?

    <p>Endocytosis of proteins into the tubular cells, followed by digestion into amino acids and exocytosis</p> Signup and view all the answers

    What happens to very small proteins like angiotensin II in the tubular fluid?

    <p>They are digested by peptidases within the luminal membrane, and the amino acids are absorbed</p> Signup and view all the answers

    Why is the term 'transported' used instead of 'reabsorbed' when referring to protein movement?

    <p>Proteins undergo structural changes during the reabsorption process</p> Signup and view all the answers

    What is the role of lysosomes in the reabsorption of proteins?

    <p>They digest the proteins into amino acids before exocytosis</p> Signup and view all the answers

    What is the primary reason for reabsorbing proteins from the tubular fluid?

    <p>To prevent the excretion of essential proteins in the urine</p> Signup and view all the answers

    Which of the following statements about protein reabsorption is correct?

    <p>Proteins are first digested into amino acids by lysosomes, then reabsorbed into the blood</p> Signup and view all the answers

    What is the primary mechanism by which sodium (Na+) moves from the tubular lumen into the tubular cells of the proximal convoluted tubule (PCT)?

    <p>Facilitated diffusion down its concentration gradient</p> Signup and view all the answers

    What is the primary function of the Na+/K+ pumps embedded in the basolateral membrane of the tubular cells?

    <p>To move Na+ from the tubular cells into the interstitial fluid</p> Signup and view all the answers

    Why is the regulation of sodium output critical for maintaining blood sodium levels within a normal homeostatic range?

    <p>Sodium intake can vary greatly from as little as 0.05 g/day to as high as 25 g/day</p> Signup and view all the answers

    What is the primary reason for the substantial energy consumption of the Na+/K+ pumps in the nephron?

    <p>They use approximately 80% of all energy invested in active transport within nephrons</p> Signup and view all the answers

    Which of the following mnemonic devices is mentioned in the text to help remember the function of aldosterone?

    <p>&quot;Al likes salt&quot; to remember that aldosterone helps retain sodium</p> Signup and view all the answers

    What is the significance of the word roots in the term 'atrial natriuretic peptide'?

    <p>The root 'natri' refers to sodium, and '-uretic' means causing excretion in urine</p> Signup and view all the answers

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