Prostate Infections Pathology Quiz
115 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the main distinction between the origins of carcinomas and nodular hyperplasia?

  • Carcinomas produce urinary obstruction early on while nodular hyperplasia is less likely to do so.
  • Carcinomas arise from centrally situated glands while nodular hyperplasia arises from peripheral glands.
  • Carcinomas are often palpable during digital examination while nodular hyperplasia is not.
  • Nodular hyperplasia arises from more centrally situated glands while carcinomas are palpable during digital examination. (correct)

What is a common cause of acute bacterial prostatitis?

  • Haemophilus influenzae
  • Staphylococcus aureus (correct)
  • Klebsiella pneumoniae
  • Chlamydia trachomatis

How might organisms reach the prostate in cases of acute prostatitis with concomitant acute urethritis and cystitis?

  • Through direct extension from the rectum
  • Through direct extension from the prostate
  • Through direct extension from the urethra or urinary bladder (correct)
  • Through direct extension from the kidneys

What can follow episodes of acute prostatitis or develop insidiously without previous episodes of acute infection?

<p>Chronic bacterial prostatitis (B)</p> Signup and view all the answers

Which nonbacterial agent is implicated in nongonococcal urethritis and can also be associated with chronic prostatitis?

<p>Chlamydia trachomatis (C)</p> Signup and view all the answers

What are the pathological features of acute prostatitis?

<p>Acute neutrophilic inflammatory infiltrate, congestion, and stromal edema (D)</p> Signup and view all the answers

What confirms prostatic inflammation in cases of chronic abacterial prostatitis?

<p>Increased number of leukocytes in prostatic secretions (D)</p> Signup and view all the answers

How might prostatitis complicate infections from distant sites other than the urethra or urinary bladder?

<p>Through blood from distant sites (A)</p> Signup and view all the answers

What treatment options can inhibit the growth of many prostatic carcinomas?

<p>Orchiectomy (B)</p> Signup and view all the answers

Which racial group shows a higher risk of symptomatic carcinoma at an earlier age?

<p>Blacks &amp; Asians (D)</p> Signup and view all the answers

What is suggested by the similar frequency of latent prostatic cancers in all races?

<p>Race influences the growth of established lesions more than initial development (C)</p> Signup and view all the answers

Where have susceptibility loci on chromosome 1 been identified in familial cases of prostate cancer?

<p>Chromosome 1 (B)</p> Signup and view all the answers

Is the incidence of carcinoma of the prostate higher in Scandinavian countries or in Japan and certain other Asian countries?

<p>Scandinavian countries (A)</p> Signup and view all the answers

What environmental factor is suggested by the increased frequency of prostatic carcinoma in certain industrial settings?

<p>Diet high in animal fat (C)</p> Signup and view all the answers

'Males immigrating from low-risk to high-risk areas maintain a lower risk of prostate cancer' - What does this suggest about the risk of disease in subsequent generations?

<p>'Risk increases' (A)</p> Signup and view all the answers

'A diet high in animal fat has been a factor' - A factor for what?

<p>'Development of prostatic carcinoma' (B)</p> Signup and view all the answers

What is required for a histologic diagnosis of chronic prostatitis?

<p>Presence of tissue destruction, fibroblastic proliferation, lymphocytes, and neutrophils (B)</p> Signup and view all the answers

In which condition can granulomatous prostatitis be seen?

<p>Disseminated TB (B)</p> Signup and view all the answers

What is a characteristic feature seen microscopically in granulomatous prostatitis?

<p>All of the above (D)</p> Signup and view all the answers

Which clinical manifestation is NOT typically associated with prostatitis?

<p>Hemoptysis (C)</p> Signup and view all the answers

What is a common symptom of acute prostatitis?

<p>Fever and leukocytosis (C)</p> Signup and view all the answers

What kind of reaction is granulomatous prostatitis to a variety of insults?

<p>Morphologic reaction (D)</p> Signup and view all the answers

When is caseous necrosis typically seen in prostatic tissue?

<p>In tuberculous prostatitis (D)</p> Signup and view all the answers

Which of the following is a manifestation of chronic prostatitis?

<p><strong>Poorly localized suprapubic pain</strong> (C)</p> Signup and view all the answers

What are the etiological factors associated with squamous cell carcinomas of the penis?

<p>Exposure to potential carcinogens in smegma, smoking, and HPV infection (B)</p> Signup and view all the answers

What is a common precursor to squamous cell carcinomas of the penis?

<p>Intraepithelial neoplasia (C)</p> Signup and view all the answers

What age group is more commonly affected by squamous cell carcinomas of the penis?

<p>Adults over 40 years old (C)</p> Signup and view all the answers

How are squamous cell carcinomas of the penis characterized in relation to circumcision?

<p>They are more common in uncircumcised individuals (B)</p> Signup and view all the answers

Which type of human papillomavirus (HPV) infection is particularly associated with squamous cell carcinomas of the penis?

<p>HPV type 16 and 18 (B)</p> Signup and view all the answers

What is a potential consequence of poor hygiene in relation to squamous cell carcinomas of the penis?

<p>Higher likelihood of exposure to potential smegma carcinogens (B)</p> Signup and view all the answers

How do early lesions of prostate cancer typically appear?

<p>Firm, gray-white to yellow lesions just beneath the capsule (B)</p> Signup and view all the answers

What is the most common location for the majority of prostate cancers to arise?

<p>Peripheral glands (D)</p> Signup and view all the answers

Which structure usually prevents the growth of the tumor posteriorly in cases of prostatic adenocarcinoma?

<p>Denonvilliers fascia (C)</p> Signup and view all the answers

What is a common feature of the foci of carcinoma seen on the cut surface of the prostate?

<p>Gray-white to yellow lesions with ill-defined margins (D)</p> Signup and view all the answers

What happens when locally advanced prostate cancers infiltrate the seminal vesicles?

<p>May invade adjacent soft tissues and urinary bladder (A)</p> Signup and view all the answers

Which structure separates the lower genitourinary structures from the rectum in cases of prostatic adenocarcinoma?

<p>Denonvilliers fascia (A)</p> Signup and view all the answers

When do metastases to regional pelvic lymph nodes typically occur in cases of prostate cancer?

<p>In early stages of the disease (C)</p> Signup and view all the answers

How does prostate cancer typically present on rectal digital examination?

<p>'Irregular hard' nodules (C)</p> Signup and view all the answers

What is a common etiological factor for squamous cell carcinomas of the penis?

<p>Smoking (C)</p> Signup and view all the answers

Which age group is most commonly affected by squamous cell carcinomas of the penis?

<p>Over 40 years old (C)</p> Signup and view all the answers

What is a notable risk factor for developing testicular neoplasms?

<p>Cryptorchidism (A)</p> Signup and view all the answers

Which human papillomavirus (HPV) types are particularly associated with squamous cell carcinomas of the penis?

<p>Types 16 and 18 (A)</p> Signup and view all the answers

What can precede squamous cell carcinomas of the penis and may eventually lead to carcinoma in situ?

<p>Dysplastic changes (C)</p> Signup and view all the answers

What is a potential complication associated with cryptorchidism?

<p>Testicular neoplasms (C)</p> Signup and view all the answers

Which of the following is a characteristic feature of squamous cell carcinomas of the penis?

<p>&quot;Carcinoma in situ&quot; (D)</p> Signup and view all the answers

"Prostatic neoplasms are relatively uncommon in which group of individuals?"

<p>&quot;Circumcised individuals&quot; (C)</p> Signup and view all the answers

What is a common feature of early lesions of prostate cancer beneath the capsule of the prostate?

<p>Smooth and well-defined masses (B)</p> Signup and view all the answers

Why is urethral obstruction less likely in the initial stages of prostate cancer compared to nodular hyperplasia?

<p>Prostate cancer arises in the outer glands (C)</p> Signup and view all the answers

In cases of prostatic adenocarcinoma, what may prevent the growth of the tumor posteriorly?

<p>Seminal vesicles (D)</p> Signup and view all the answers

What is a characteristic feature of foci of carcinoma on the cut surface of the prostate?

<p>Sharp and well-defined margins (A)</p> Signup and view all the answers

What structure separates the lower genitourinary structures from the rectum in cases of prostatic adenocarcinoma?

<p>Prostate capsule (B)</p> Signup and view all the answers

Where do metastases to regional pelvic lymph nodes typically occur early in cases of prostate cancer?

<p>Seminal vesicles (B)</p> Signup and view all the answers

How do majority of prostate cancers typically arise in relation to their location within the glands?

<p>In inner central glands (A)</p> Signup and view all the answers

What is the major hormonal stimulus for stromal and glandular proliferation in men with nodular hyperplasia?

<p>Dihydrotestosterone (B)</p> Signup and view all the answers

Which zone of the prostate is most commonly affected by hyperplastic lesions?

<p>Transitional (C)</p> Signup and view all the answers

What is the characteristic feature of BPH?

<p>Proliferation of both stromal and epithelial elements (C)</p> Signup and view all the answers

Which age group is significantly affected by BPH?

<p>Men by the age of 40 and older (D)</p> Signup and view all the answers

What role do androgens play in the pathogenesis of BPH?

<p>Central role (B)</p> Signup and view all the answers

Where do most carcinomas arise in the prostate?

<p>Peripheral zones (B)</p> Signup and view all the answers

What does DHT bind to in men with nodular hyperplasia?

<p>Nuclear androgen receptors (D)</p> Signup and view all the answers

What is a reliable indicator of the presence of a nonseminomatous component to the germ cell neoplasm?

<p>Elevated AFP levels (B)</p> Signup and view all the answers

Which germ cell tumor may also secrete hCG, although at a lower rate compared to choriocarcinoma?

<p>Seminoma (D)</p> Signup and view all the answers

What is the function of hCG in patients with choriocarcinoma?

<p>Contribute to tumor growth (A)</p> Signup and view all the answers

Which tumor marker indicates the presence of neoplastic syncytiotrophoblastic cells in germ cell tumors?

<p>hCG (D)</p> Signup and view all the answers

In germ cell tumors, what does elevation of both hCG and AFP levels suggest?

<p>Nonseminomatous tumor with yolk sac elements (A)</p> Signup and view all the answers

What is the primary role of serial determinations of hCG and AFP in germ cell tumors post-therapy?

<p>Monitoring for tumor recurrence (D)</p> Signup and view all the answers

What is the significance of elevated AFP levels in germ cell tumors?

<p>Reliable indicator for nonseminomatous component (B)</p> Signup and view all the answers

Which tumor marker differentiates between pure seminomas and those with nonseminomatous components?

<p>AFP (C)</p> Signup and view all the answers

What grading system for carcinoma of the prostate is commonly used and correlates well with the stage and prognosis of the disease?

<p>Gleason system (C)</p> Signup and view all the answers

How may more extensive prostate cancer disease typically manifest?

<p>Local discomfort and lower urinary tract obstruction (B)</p> Signup and view all the answers

What histologic feature allows the neoplastic glands of prostatic adenocarcinoma to be recognizable at high magnification?

<p>Hyperchromatic nuclei (A)</p> Signup and view all the answers

In what percentage of cases are carcinomas localized and discovered unexpectedly during histologic examination of tissues removed for nodular hyperplasia?

<p>~10% (C)</p> Signup and view all the answers

How do the neoplastic glands in prostatic adenocarcinoma differ from normal glands at high magnification?

<p>Hyperchromatic nuclei (D)</p> Signup and view all the answers

What clinical manifestation may reveal aggressive carcinomas that are first noticed due to the presence of metastases?

<p>Hard, fixed prostate (B)</p> Signup and view all the answers

What feature of prostatic carcinoma back to back glands distinguishes them under high magnification?

<p>Intervening stroma present (D)</p> Signup and view all the answers

Which tumor marker is a reliable indicator of the presence of a nonseminomatous component in germ cell neoplasms?

<p>AFP (B)</p> Signup and view all the answers

What is the characteristic tumor marker secreted by neoplastic syncytiotrophoblastic cells in choriocarcinoma?

<p>hCG (A)</p> Signup and view all the answers

Which zone of the normal prostate contains several distinct regions, including central, peripheral, transitional, and periurethral zones?

<p>Central zone (C)</p> Signup and view all the answers

Which tumor marker is commonly associated with germ cell tumors containing yolk sac (endodermal sinus) elements?

<p>AFP (B)</p> Signup and view all the answers

What is the significant hormonal stimulus for stromal and glandular proliferation in men with nodular hyperplasia?

<p>Androgens (A)</p> Signup and view all the answers

What is the major grading system used for prostatic carcinoma that correlates well with the stage and prognosis of the disease?

<p>Gleason system (C)</p> Signup and view all the answers

How do the neoplastic glands of prostatic adenocarcinoma appear at high magnification?

<p>Without intervening stroma and hyperchromatic nuclei (D)</p> Signup and view all the answers

What is a distinguishing feature of prostatic adenocarcinoma lymph node metastasis?

<p>Left supraclavicular lymphadenopathy (C)</p> Signup and view all the answers

In what group of individuals are prostatic neoplasms relatively uncommon?

<p>Females transitioning to males (D)</p> Signup and view all the answers

What tumor marker is typically elevated in choriocarcinoma and differentiates between pure seminomas and nonseminomatous components?

<p>Beta-human chorionic gonadotropin (hCG) (A)</p> Signup and view all the answers

What is a distinctive histopathological feature of seminomas?

<p>Distinct cell borders, clear cytoplasm, and round nuclei with nucleoli (C)</p> Signup and view all the answers

Which age group does embryonal carcinoma most frequently occur in?

<p>25-35 years (A)</p> Signup and view all the answers

What distinguishes prostatic adenocarcinoma from normal glands microscopically?

<p>Back to back forming of glands (D)</p> Signup and view all the answers

What is a common feature of early lesions of prostate cancer beneath the capsule?

<p>Retroperitoneal lymph node metastases (B)</p> Signup and view all the answers

Which marker helps differentiate pure seminomas from those with nonseminomatous components?

<p>Human chorionic gonadotropin (hCG) (C)</p> Signup and view all the answers

What is a common feature of prostatic adenocarcinoma when compared to normal or hyperplastic prostate glands?

<p>Glands are lined by a single layer of cuboidal cells with basal cell layer present (C)</p> Signup and view all the answers

Which tumor marker is commonly elevated in patients with choriocarcinoma?

<p>AFP (Alpha-Fetoprotein) (B)</p> Signup and view all the answers

What histological pattern is suggestive of high-grade prostatic intraepithelial neoplasia (PIN), a possible precursor to prostatic carcinoma?

<p>Papillary structures and cribriform epithelial arrangements (C)</p> Signup and view all the answers

What distinguishes pure seminomas from those with nonseminomatous components in germ cell tumors?

<p>Elevation of both hCG and AFP levels (A)</p> Signup and view all the answers

Which microscopic feature is characteristic of better-differentiated lesions of prostatic adenocarcinoma?

<p>Single layer of cuboidal cells with conspicuous nucleoli (D)</p> Signup and view all the answers

Which testicular germ cell tumor is most commonly encountered in combination with teratoma and yolk sac tumors?

<p>Embryonal carcinoma (D)</p> Signup and view all the answers

In testicular germ cell tumors, which type tends to metastasize earlier via lymphatic and hematogenous routes?

<p>Teratoma (A)</p> Signup and view all the answers

Which location is most common for hematogenous metastases in seminomas?

<p>Liver and lungs (A)</p> Signup and view all the answers

What is the distinctive clinical presentation of individuals with nonseminomatous testicular germ cell neoplasms?

<p>Widespread metastases at diagnosis (D)</p> Signup and view all the answers

Which zone of the prostate is most commonly affected by adenocarcinoma?

<p>Peripheral zone (A)</p> Signup and view all the answers

What is the distinctive feature characterized by the presence of structures resembling primitive glomeruli in a histological section of the testis?

<p>Schiller-Duvall bodies (B)</p> Signup and view all the answers

What is a typical gross characteristic of choriocarcinomas?

<p>Small nonpalpable lesions (D)</p> Signup and view all the answers

Which immunohistochemical staining technique can identify the hormone hCG in choriocarcinomas?

<p>hCG staining (A)</p> Signup and view all the answers

What type of differentiation is represented by sheets of small cuboidal cells intermingled with large eosinophilic syncytial cells in choriocarcinomas?

<p>Syncytiotrophoblastic differentiation (D)</p> Signup and view all the answers

In which cells can AFP be demonstrated within the cytoplasm by immunohistochemical techniques in germ cell tumors?

<p>Neoplastic cells (D)</p> Signup and view all the answers

Which condition is more likely to produce urinary obstruction early in its course than carcinoma?

<p>Nodular hyperplasia (B)</p> Signup and view all the answers

What is the characteristic pathological feature of acute prostatitis?

<p>Neutrophilic inflammatory infiltrate (B)</p> Signup and view all the answers

Which type of prostatitis accounts for most cases of chronic prostatitis?

<p>Chronic abacterial prostatitis (A)</p> Signup and view all the answers

In chronic prostatitis, what confirms prostatic inflammation when bacteriologic findings are negative?

<p>Increased leukocytes in prostatic secretions (D)</p> Signup and view all the answers

What is a significant finding that suggests the presence of a nonseminomatous component in germ cell tumors?

<p>Elevated hCG levels (B)</p> Signup and view all the answers

What pathological feature distinguishes back-to-back glands in prostatic carcinoma under high magnification?

<p>Stromal and glandular proliferation (B)</p> Signup and view all the answers

'A diet high in animal fat has been a factor' - A factor for what condition?

<p>Prostatic adenocarcinoma (C)</p> Signup and view all the answers

'Males immigrating from low-risk to high-risk areas maintain a lower risk of prostate cancer' - What does this suggest about the risk of disease in subsequent generations?

<p>Increased risk of prostatic adenocarcinoma (D)</p> Signup and view all the answers

What is the major hormonal stimulus for stromal and glandular proliferation in men with nodular hyperplasia?

<p>Androgens (A)</p> Signup and view all the answers

What characteristic feature is seen microscopically in granulomatous prostatitis?

<p>Granulomatous inflammation (B)</p> Signup and view all the answers

Flashcards

Nodular Hyperplasia Origins

Arises from centrally situated glands, unlike carcinomas.

Acute Bacterial Prostatitis Cause

Commonly caused by Staphylococcus aureus.

Infection Pathway in Prostatitis

Organisms may reach the prostate from the urethra or bladder.

Chronic Bacterial Prostatitis

Can occur after acute prostatitis or develop without prior infection.

Signup and view all the flashcards

Nonbacterial Urethritis Agent

Chlamydia trachomatis is associated with chronic prostatitis.

Signup and view all the flashcards

Pathological Features of Acute Prostatitis

Involves neutrophilic infiltrate, congestion, and edema.

Signup and view all the flashcards

Confirmed Inflammation

Increased leukocytes in prostatic secretions confirm chronic prostatitis.

Signup and view all the flashcards

Prostatitis Complications

Can complicate infections via distant blood flows.

Signup and view all the flashcards

Prostate Cancer Growth Inhibition

Orchiectomy can inhibit many prostatic carcinomas.

Signup and view all the flashcards

Racial Risk Factors for Prostate Cancer

Blacks and Asians show higher risk of early symptomatic carcinoma.

Signup and view all the flashcards

Latent Prostatic Cancers Across Races

Similar latent cancer frequency suggests race influences lesion growth.

Signup and view all the flashcards

Familial Prostate Cancer Susceptibility

Identified loci on chromosome 1 in familial cases.

Signup and view all the flashcards

Prostate Cancer Incidence

Higher in Scandinavian countries compared to Japan/Asia.

Signup and view all the flashcards

Dietary Influence on Prostate Cancer

High animal fat diet linked to increased prostatic carcinoma.

Signup and view all the flashcards

Immigration and Prostate Cancer Risk

Males from low-risk to high-risk areas see increased risk in offspring.

Signup and view all the flashcards

Histologic Diagnosis of Chronic Prostatitis

Requires tissue destruction, fibrosis, lymphocytes, and neutrophils.

Signup and view all the flashcards

Granulomatous Prostatitis Condition

Can be seen in disseminated tuberculosis.

Signup and view all the flashcards

Acute Prostatitis Symptoms

Commonly includes fever and leukocytosis.

Signup and view all the flashcards

Dysplastic Changes and Cancer

Precede squamous cell carcinomas of the penis leading to carcinoma in situ.

Signup and view all the flashcards

Circumcision and Prostate Cancer

Prostatic neoplasms are rare in circumcised individuals.

Signup and view all the flashcards

HPV Typing in Penile Cancer

HPV types 16 and 18 are particularly associated with squamous cell carcinomas.

Signup and view all the flashcards

Clinical Presentation of Prostate Cancer

Typically presents as irregular hard nodules on digital exam.

Signup and view all the flashcards

Squamous Cell Carcinoma Risk Factor

Smoking is a common etiological factor.

Signup and view all the flashcards

Age and Squamous Cell Carcinoma

Most affected age group is over 40 years old.

Signup and view all the flashcards

Testicular Neoplasms and Cryptorchidism

Cryptorchidism is a notable risk factor for testicular neoplasms.

Signup and view all the flashcards

Prostate Cancer Tumor Growth

Denonvilliers fascia usually prevents growth posteriorly in adenocarcinoma.

Signup and view all the flashcards

Local Spread of Prostate Cancer

Locally advanced cancers may invade adjacent soft tissue and bladder.

Signup and view all the flashcards

More Like This

Prostate Cancer Overview
12 questions

Prostate Cancer Overview

FuturisticSparrow avatar
FuturisticSparrow
Gleason Grade and Score in Prostate Cancer
5 questions
Causas de la micción urgente
10 questions
Prostate Health and Disease Quiz
24 questions
Use Quizgecko on...
Browser
Browser