24 Questions
Which of the following antibacterial agents is known to inhibit bacterial protein synthesis by binding with the 50S ribosomal subunit?
Macrolides
What is the primary mechanism of action of Polymyxin B?
Interference with cell membrane phospholipid
Which of the following antibacterial agents is characterized by a narrow spectrum of activity against G-ve bacteria?
Polymyxin B
What is the primary reason for the high systemic toxicity of polypeptides?
Their ability to interfere with cell membrane phospholipid
Which of the following antibacterial agents is commonly used as a growth promoter in animal feed?
Bacitracin
What is the primary mechanism of action of Macrolides?
Inhibition of protein synthesis
Which of the following antibacterial agents is characterized by a narrow spectrum of activity against G+ve and Clostridial bacteria?
Bacitracin
What is the primary route of administration for Polymyxin B?
Intramuscular administration
Which mechanism allows tetracyclines to inhibit bacterial growth?
Binding with 30S ribosomal subunit
Which antibacterial agent is associated with teeth discoloration as a side effect?
Doxycycline
Which is a common resistance mechanism for tetracyclines?
Efflux pumps
What is a characteristic feature of chloramphenicol’s mode of action?
Inhibits 50S ribosomal subunit
Why is chloramphenicol less effective in ruminants?
It is inactivated in the rumen
What is the therapeutic use of doxycycline in infections?
E. coli infection
Which side effect is NOT associated with tetracyclines?
Aplastic anemia
What distinguishes doxycycline from other tetracyclines in terms of absorption?
Absorption is unaffected by the presence of calcium
What is the main target of beta-lactam antibiotics in bacterial cells?
Bacterial cell wall formation
Which of the following is a correct strategy to control antibacterial resistance?
Combining some drugs to reduce chromosomal resistance development
What is a common side effect of beta-lactam antibiotics?
G.I.T upset (Anorexia, vomiting & diarrhea)
Penicillinase E produced by some Gram-positive bacteria has what effect?
Destroys penicillin
What is the role of Clavulanic Acid when used with Amoxicillin?
Inactivates penicillinase
Which statement is true about the pharmacokinetics of Penicillin?
Penicillin is widely distributed through the body fluids.
Which of the following bacterial characteristics contributes to resistance against penicillins?
Ability to produce beta-lactamase enzymes
Which statement about beta-lactam antibacterial agents is most accurate?
They are bactericidal and narrow-spectrum for Gram-positive bacteria.
Learn about the antibacterial properties of Tetracyclines, their mode of action, spectrum, and pharmacokinetics, including absorption, distribution, and potential side effects.
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