Pharmacology: Tetracyclines Antibacterial Agent
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Questions and Answers

Which of the following antibacterial agents is known to inhibit bacterial protein synthesis by binding with the 50S ribosomal subunit?

  • Macrolides (correct)
  • Polypeptides
  • Bacitracin
  • Polymyxin B

    • What is the primary mechanism of action of Polymyxin B?

  • Inhibition of cell wall synthesis
  • Inhibition of protein synthesis
  • Inhibition of DNA replication
  • Interference with cell membrane phospholipid (correct)

    • Which of the following antibacterial agents is characterized by a narrow spectrum of activity against G-ve bacteria?

  • Erythromycin
  • Polymyxin B (correct)
  • Macrolides
  • Bacitracin

    • What is the primary reason for the high systemic toxicity of polypeptides?

    <p>Their ability to interfere with cell membrane phospholipid</p> Signup and view all the answers

    Which of the following antibacterial agents is commonly used as a growth promoter in animal feed?

    <p>Bacitracin</p> Signup and view all the answers

    What is the primary mechanism of action of Macrolides?

    <p>Inhibition of protein synthesis</p> Signup and view all the answers

    Which of the following antibacterial agents is characterized by a narrow spectrum of activity against G+ve and Clostridial bacteria?

    <p>Bacitracin</p> Signup and view all the answers

    What is the primary route of administration for Polymyxin B?

    <p>Intramuscular administration</p> Signup and view all the answers

    Which mechanism allows tetracyclines to inhibit bacterial growth?

    <p>Binding with 30S ribosomal subunit</p> Signup and view all the answers

    Which antibacterial agent is associated with teeth discoloration as a side effect?

    <p>Doxycycline</p> Signup and view all the answers

    Which is a common resistance mechanism for tetracyclines?

    <p>Efflux pumps</p> Signup and view all the answers

    What is a characteristic feature of chloramphenicol’s mode of action?

    <p>Inhibits 50S ribosomal subunit</p> Signup and view all the answers

    Why is chloramphenicol less effective in ruminants?

    <p>It is inactivated in the rumen</p> Signup and view all the answers

    What is the therapeutic use of doxycycline in infections?

    <p>E. coli infection</p> Signup and view all the answers

    Which side effect is NOT associated with tetracyclines?

    <p>Aplastic anemia</p> Signup and view all the answers

    What distinguishes doxycycline from other tetracyclines in terms of absorption?

    <p>Absorption is unaffected by the presence of calcium</p> Signup and view all the answers

    What is the main target of beta-lactam antibiotics in bacterial cells?

    <p>Bacterial cell wall formation</p> Signup and view all the answers

    Which of the following is a correct strategy to control antibacterial resistance?

    <p>Combining some drugs to reduce chromosomal resistance development</p> Signup and view all the answers

    What is a common side effect of beta-lactam antibiotics?

    <p>G.I.T upset (Anorexia, vomiting &amp; diarrhea)</p> Signup and view all the answers

    Penicillinase E produced by some Gram-positive bacteria has what effect?

    <p>Destroys penicillin</p> Signup and view all the answers

    What is the role of Clavulanic Acid when used with Amoxicillin?

    <p>Inactivates penicillinase</p> Signup and view all the answers

    Which statement is true about the pharmacokinetics of Penicillin?

    <p>Penicillin is widely distributed through the body fluids.</p> Signup and view all the answers

    Which of the following bacterial characteristics contributes to resistance against penicillins?

    <p>Ability to produce beta-lactamase enzymes</p> Signup and view all the answers

    Which statement about beta-lactam antibacterial agents is most accurate?

    <p>They are bactericidal and narrow-spectrum for Gram-positive bacteria.</p> Signup and view all the answers

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