Pharmacology: Tetracyclines Antibacterial Agent
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Questions and Answers

Which of the following antibacterial agents is known to inhibit bacterial protein synthesis by binding with the 50S ribosomal subunit?

  • Macrolides (correct)
  • Polypeptides
  • Bacitracin
  • Polymyxin B

What is the primary mechanism of action of Polymyxin B?

  • Inhibition of cell wall synthesis
  • Inhibition of protein synthesis
  • Inhibition of DNA replication
  • Interference with cell membrane phospholipid (correct)

Which of the following antibacterial agents is characterized by a narrow spectrum of activity against G-ve bacteria?

  • Erythromycin
  • Polymyxin B (correct)
  • Macrolides
  • Bacitracin

What is the primary reason for the high systemic toxicity of polypeptides?

<p>Their ability to interfere with cell membrane phospholipid (B)</p> Signup and view all the answers

Which of the following antibacterial agents is commonly used as a growth promoter in animal feed?

<p>Bacitracin (C)</p> Signup and view all the answers

What is the primary mechanism of action of Macrolides?

<p>Inhibition of protein synthesis (D)</p> Signup and view all the answers

Which of the following antibacterial agents is characterized by a narrow spectrum of activity against G+ve and Clostridial bacteria?

<p>Bacitracin (C)</p> Signup and view all the answers

What is the primary route of administration for Polymyxin B?

<p>Intramuscular administration (A)</p> Signup and view all the answers

Which mechanism allows tetracyclines to inhibit bacterial growth?

<p>Binding with 30S ribosomal subunit (C)</p> Signup and view all the answers

Which antibacterial agent is associated with teeth discoloration as a side effect?

<p>Doxycycline (D)</p> Signup and view all the answers

Which is a common resistance mechanism for tetracyclines?

<p>Efflux pumps (C)</p> Signup and view all the answers

What is a characteristic feature of chloramphenicol’s mode of action?

<p>Inhibits 50S ribosomal subunit (A)</p> Signup and view all the answers

Why is chloramphenicol less effective in ruminants?

<p>It is inactivated in the rumen (C)</p> Signup and view all the answers

What is the therapeutic use of doxycycline in infections?

<p>E. coli infection (C)</p> Signup and view all the answers

Which side effect is NOT associated with tetracyclines?

<p>Aplastic anemia (A)</p> Signup and view all the answers

What distinguishes doxycycline from other tetracyclines in terms of absorption?

<p>Absorption is unaffected by the presence of calcium (C)</p> Signup and view all the answers

What is the main target of beta-lactam antibiotics in bacterial cells?

<p>Bacterial cell wall formation (A)</p> Signup and view all the answers

Which of the following is a correct strategy to control antibacterial resistance?

<p>Combining some drugs to reduce chromosomal resistance development (B)</p> Signup and view all the answers

What is a common side effect of beta-lactam antibiotics?

<p>G.I.T upset (Anorexia, vomiting &amp; diarrhea) (B)</p> Signup and view all the answers

Penicillinase E produced by some Gram-positive bacteria has what effect?

<p>Destroys penicillin (C)</p> Signup and view all the answers

What is the role of Clavulanic Acid when used with Amoxicillin?

<p>Inactivates penicillinase (A)</p> Signup and view all the answers

Which statement is true about the pharmacokinetics of Penicillin?

<p>Penicillin is widely distributed through the body fluids. (D)</p> Signup and view all the answers

Which of the following bacterial characteristics contributes to resistance against penicillins?

<p>Ability to produce beta-lactamase enzymes (C)</p> Signup and view all the answers

Which statement about beta-lactam antibacterial agents is most accurate?

<p>They are bactericidal and narrow-spectrum for Gram-positive bacteria. (A)</p> Signup and view all the answers

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