Questions and Answers
What class of antibiotics is effective against gram negative and gram positive bacteria?
Why is protein synthesis important in antibiotics?
Because antibiotics stop protein synthesis so cells can't divide
What are tetracyclines used for?
They are used in patients allergic to penicillins for the treatment of certain venereal diseases, UTIs, upper respiratory tract infections, pneumonia, and meningitis
What are tetracyclines particularly effective against?
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What happens when tetracyclines are administered during the ages of tooth development?
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Are tetracyclines secreted in breast milk?
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What is the therapeutic outcome for tetracyclines?
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What premedication assessment should be done for tetracyclines?
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How are tetracyclines available?
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What are common adverse effects of tetracyclines?
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How may warfarin interact with tetracyclines?
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Administer all tetracycline products 1 hour or 2 hours after ingesting because of decreased absorption of ____.
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Do not administer tetracycline within 2 hours of taking ____ or ____.
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Study Notes
Tetracyclines Overview
- Class of antibiotics effective against both gram-negative and gram-positive bacteria
- Function by inhibiting protein synthesis in bacterial cells
Importance of Protein Synthesis
- Stopping protein synthesis prevents bacterial cell division and replication
Uses of Tetracyclines
- Alternative treatment for patients allergic to penicillins
- Indicated for certain venereal diseases, UTIs, upper respiratory infections, pneumonia, and meningitis
Effectiveness
- Particularly effective for skin infections (acne), rickettsial infections, and mycoplasmic infections
Impact on Tooth Development
- Administration during tooth development (from second half of pregnancy to age 8) can lead to enamel hypoplasia and permanent tooth staining
Breast Milk Secretion
- Tetracyclines are secreted in breast milk, which might pose risks for nursing infants
Therapeutic Outcome
- Aims for the elimination of bacterial infections in patients
Premedication Assessment
- Obtain baseline assessments: presenting symptoms, temperature, pulse, respirations, blood pressure, and hydration status
- Assess for gastric symptoms, allergies, and complete necessary lab studies before therapy
Availability
- Tetracyclines are available in oral (PO) form
Common Adverse Effects
- Adverse effects include nausea, vomiting, abdominal cramps, diarrhea, and photosensitivity
Interaction with Warfarin
- Tetracyclines may enhance the anticoagulant effects of warfarin, increasing bleeding risk
- Monitor for signs of bleeding such as petechiae, ecchymoses, nosebleeds, bleeding gums, and dark or bloody stools
Administration Guidelines
- Administer tetracycline products at least 1 hour before or 2 hours after ingestion of substances that decrease absorption, including:
- Iron
- Calcium-containing foods
- Calcium supplements
- Aluminum and magnesium preparations
Contraindications for Co-administration
- Avoid administering tetracycline within 2 hours of taking didanosine or pediatric powder for oral solution due to absorption inhibition caused by antacids in these products
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Description
Test your knowledge on tetracycline antibiotics with this quiz. Discover how they function and their importance in clinical settings. Learn about their applications and mechanisms in bacterial infections.
