Lecture 22&23
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Questions and Answers

What is the primary mechanism of action of thiazide diuretics?

  • Inhibiting carbonic anhydrase in the proximal convoluted tubule
  • Inhibiting Na-Cl cotransporter in the early distal tubule (correct)
  • Inhibiting the Na+/K+ pump in the collecting duct
  • Stimulating the release of atrial natriuretic peptide

Which of the following is NOT a potassium-sparing diuretic?

  • Spironolactone
  • Furosemide (correct)
  • Amiloride
  • Triamterene

What is the main effect of diuretic drugs on the body?

  • Decreased blood pressure and increased heart rate
  • Reduced urine flow and increased extracellular fluid volume
  • Increased sodium reabsorption and water retention
  • Increased urine flow and removal of excess extracellular fluid and electrolytes (correct)

Which diuretic class acts by inhibiting carbonic anhydrase?

<p>Carbonic anhydrase inhibitors (D)</p> Signup and view all the answers

What is the primary site of action of loop diuretics?

<p>Thick ascending limb of the loop of Henle (C)</p> Signup and view all the answers

What is the primary consequence of diuretic action?

<p>Increased urine flow and removal of excess extracellular fluid and electrolytes (B)</p> Signup and view all the answers

What is the primary effect of thiazide diuretics on the body's sodium levels?

<p>Increased sodium excretion (D)</p> Signup and view all the answers

What is a common adverse effect of both thiazide and loop diuretics?

<p>Hypokalemia (D)</p> Signup and view all the answers

What is the mechanism of action of loop diuretics?

<p>Inhibition of the cotransport of Na+/K+/2Cl– in the luminal membrane (C)</p> Signup and view all the answers

Which of the following is a therapeutic use of thiazide diuretics?

<p>Treatment of hypertension (C)</p> Signup and view all the answers

What is the effect of thiazide diuretics on urinary calcium excretion?

<p>Decreased calcium excretion (C)</p> Signup and view all the answers

Which of the following is a unique adverse effect of loop diuretics?

<p>Ototoxicity (C)</p> Signup and view all the answers

What is the primary mechanism of action of potassium-sparing diuretics?

<p>Inhibiting Na+ reabsorption and K+ excretion in the collecting tubule (C)</p> Signup and view all the answers

What is the main therapeutic use of loop diuretics?

<p>Reducing acute pulmonary edema of heart failure (A)</p> Signup and view all the answers

What is a common adverse effect of carbonic anhydrase inhibitors?

<p>Hypokalemia (D)</p> Signup and view all the answers

What is the mechanism of action of osmotic diuretics?

<p>Increasing fluid loss through osmotic activity (A)</p> Signup and view all the answers

What is a common adverse effect of potassium-sparing diuretics?

<p>Hyperkalemia (C)</p> Signup and view all the answers

What is the primary therapeutic use of spironolactone?

<p>Treatment of heart failure (C)</p> Signup and view all the answers

What is the primary site of action of thiazide diuretics in the nephron?

<p>Early distal tubule (B)</p> Signup and view all the answers

Which of the following diuretics inhibits Na-Cl cotransporter in the early distal tubule?

<p>Hydrochlorothiazide (B)</p> Signup and view all the answers

What is the effect of diuretics on the body's sodium levels?

<p>Decreased (A)</p> Signup and view all the answers

Which of the following is a common property of all diuretics?

<p>Increased urine flow (C)</p> Signup and view all the answers

Which of the following diuretics is not a potassium-sparing diuretic?

<p>Hydrochlorothiazide (C)</p> Signup and view all the answers

What is the primary mechanism of action of diuretics in the nephron?

<p>Inhibition of ion transport (B)</p> Signup and view all the answers

What is a unique adverse effect of thiazide diuretics?

<p>Erectile dysfunction (C)</p> Signup and view all the answers

What is the effect of loop diuretics on sodium levels in the body?

<p>Increased excretion of 15-25% of filtered sodium (C)</p> Signup and view all the answers

What is a common adverse effect of both thiazide and loop diuretics?

<p>All of the above (D)</p> Signup and view all the answers

What is the mechanism of action of loop diuretics?

<p>Inhibition of Na+/K+/2Cl– cotransport (C)</p> Signup and view all the answers

What is a therapeutic use of thiazide diuretics?

<p>Treatment of hypertension (A)</p> Signup and view all the answers

What is a potential adverse effect of loop diuretics when used with aminoglycoside antibiotics?

<p>Ototoxicity (D)</p> Signup and view all the answers

Which type of diuretics are used as adjunct therapy, usually with thiazide and loop diuretics?

<p>Potassium-sparing diuretics (A)</p> Signup and view all the answers

What is the primary effect of osmotic diuretics on the body?

<p>Increased fluid loss due to osmotically active diuretics (B)</p> Signup and view all the answers

What is a common adverse effect of carbonic anhydrase inhibitors?

<p>Metabolic acidosis (C)</p> Signup and view all the answers

What is a therapeutic use of loop diuretics?

<p>Treating acute pulmonary edema of heart failure (C)</p> Signup and view all the answers

What is a common adverse effect of potassium-sparing diuretics?

<p>Hyperkalemia (D)</p> Signup and view all the answers

What is the mechanism of action of carbonic anhydrase inhibitors?

<p>Inhibiting the enzyme carbonic anhydrase (A)</p> Signup and view all the answers

What is a therapeutic use of potassium-sparing diuretics?

<p>Used in adjunct therapy (B)</p> Signup and view all the answers

What is a common adverse effect of loop diuretics?

<p>Metabolic alkalosis (C)</p> Signup and view all the answers

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