Podcast
Questions and Answers
What is a potential consequence of using sodium bicarbonate as an antacid for an extended period?
What is a potential consequence of using sodium bicarbonate as an antacid for an extended period?
- Systemic acidosis
- Reduced gastric emptying
- Rebound hyperacidity (correct)
- Increased calcium absorption
What characteristic of histamine antagonists, such as ranitidine, is critical for their mechanism of action?
What characteristic of histamine antagonists, such as ranitidine, is critical for their mechanism of action?
- They block H1 receptors.
- They enhance gastric acid secretion.
- They increase gastric motility.
- They inhibit gastric acid secretion. (correct)
Which of the following medications requires caution to prevent toxicity due to increased serum levels?
Which of the following medications requires caution to prevent toxicity due to increased serum levels?
- Aluminum hydroxide
- Omeprazole (correct)
- Ranitidine
- Warfarin
What should patients be advised against doing with capsule forms of gastric pump inhibitors?
What should patients be advised against doing with capsule forms of gastric pump inhibitors?
Which type of drug is commonly used for short-term treatment of gastric or duodenal ulcers?
Which type of drug is commonly used for short-term treatment of gastric or duodenal ulcers?
Study Notes
Antacids
- Aluminum hydroxide, Sodium bicarbonate, Calcium carbonate, Aluminum carbonate, Aluminum hydro are examples of antacids
- Antacids decrease the absorption of medications such as tetracyclines and oral contraceptives
- Prolonged sodium bicarbonate use can lead to systemic alkalosis and rebound hyperacidity
- Antacids are not a safe source of calcium
- Antacids have a high sodium, aluminum, magnesium, and calcium content
Gastric Pump Inhibitors
- Omeprazole, Pantoprazole, Lansoprazole are examples of Gastrointestinal drugs that are commonly used for treatment of GERD, duodenal ulcers, and benign gastric ulcers
- These medications should be taken before meals (ac)
- Do not open, chew, or crush the capsules
- Gastric pump inhibitors decrease the absorption of medications such as diazepam, warfarin, and phenytoin
- They increase serum levels and potential toxicity of benzodiazepines
- Common side effects include: headache, dizziness, diarrhea, abdominal pain, nausea, vomiting, and upper respiratory infection symptoms
- Overdose symptoms include: Hypothermia, sedation, convulsions, decreased respirations
Histamine Antagonists
- Ranitidine and Famotidine are examples of Histamine Antagonists
- Inhibits gastric acid secretion by blocking histamine effect on H2 receptors
- Histamine Antagonists are used in the short-term treatment of gastric / duodenal ulcers
- IV administration should be delivered over 30 minutes to avoid bradycardia
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Description
This quiz covers important information on antacids and gastric pump inhibitors, including their common examples, effects on medication absorption, and potential side effects. Learn the implications of prolonged use and the best practices for administering these medications.
