Pharmacology III Lecture 1: Anti-inflammatory Drugs
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Questions and Answers

What is the primary purpose of inflammation in the body?

  • To inactivate or destroy invading organisms (correct)
  • To produce autoantibodies
  • To activate the immune system
  • To cause tissue injury
  • In rheumatoid arthritis (RA), which cells initiate the inflammatory attack?

  • B lymphocytes
  • T lymphocytes (correct)
  • Monocytes
  • Macrophages
  • Which of the following cytokines is secreted into the synovial cavity in rheumatoid arthritis?

  • Interleukin-6 (IL-6)
  • Tumor necrosis factor (TNF)-a (correct)
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF)
  • Interferon-gamma (IFN-γ)
  • What is the role of B lymphocytes in rheumatoid arthritis?

    <p>Producing rheumatoid factor and other autoantibodies</p> Signup and view all the answers

    What are the goals of pharmacotherapy for rheumatoid arthritis?

    <p>Reducing inflammation and pain, halting disease progression</p> Signup and view all the answers

    What are the consequences of inappropriate activation of the immune system?

    <p>Inflammation and immunemediated diseases such as RA</p> Signup and view all the answers

    Which enzyme is responsible for the physiologic production of prostanoids?

    <p>Cyclooxygenase-1 (COX-1)</p> Signup and view all the answers

    What is the primary precursor of the prostaglandins and related compounds?

    <p>Arachidonic acid</p> Signup and view all the answers

    Which type of acids are related to thromboxanes, leukotrienes, HPETEs, and HETEs?

    <p>Unsaturated fatty acids</p> Signup and view all the answers

    What is the primary function of prostaglandins in the gastrointestinal (GI) tract?

    <p>Control acid secretion and mucus production</p> Signup and view all the answers

    Which pathway is responsible for the synthesis of all eicosanoids with 3 ring structures?

    <p>COX-1 pathway</p> Signup and view all the answers

    Which type of drugs act by inhibiting the cyclooxygenase enzymes that catalyze the first step in prostanoid biosynthesis?

    <p>Non-steroidal anti-inflammatory drugs (NSAIDs)</p> Signup and view all the answers

    Which enzyme causes the elevated production of prostanoids that occurs in sites of disease and inflammation?

    <p>Cyclooxygenase-2 (COX-2)</p> Signup and view all the answers

    'All NSAIDs act by inhibiting the cyclooxygenase enzymes' - This statement is:

    <p>True</p> Signup and view all the answers

    'Thromboxanes, leukotrienes, HPETEs, and HETEs are related lipids synthesized from different precursors than prostaglandins' - This statement is:

    <p>False</p> Signup and view all the answers

    What is the primary precursor of eicosanoids?

    <p>Arachidonic acid</p> Signup and view all the answers

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