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Pharmacology III Lecture 1: Anti-Inflammatory Drugs

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Pharmacology III Lecture 1: Anti-Inflammatory Drugs

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Questions and Answers

What is the primary purpose of inflammation in the body?

To remove irritants (correct)

To stimulate T lymphocytes

To initiate an immune response

To destroy invading organisms

Which type of cells initiate an inflammatory attack in rheumatoid arthritis (RA)?

White blood cells (WBCs) (correct)

Platelets

Lymphocytes

Red blood cells (RBCs)

What do monocytes and macrophages secrete into the synovial cavity in RA?

Proinflammatory cytokines (correct)

Hormones

Anti-inflammatory cytokines

Growth factors

Which cells produce rheumatoid factor and other autoantibodies in RA?

B lymphocytes Signup and view all the answers

What is the primary goal of pharmacotherapy for rheumatoid arthritis (RA)?

To reduce inflammation and pain Signup and view all the answers

Inappropriate activation of the immune system can result in inflammation and immunemediated diseases such as:

Rheumatoid arthritis (RA) Signup and view all the answers

What is the primary precursor of prostaglandins and related compounds?

Arachidonic acid Signup and view all the answers

Which enzyme is responsible for the physiologic production of prostanoids?

Cyclooxygenase-1 (COX-1) Signup and view all the answers

Where is Cyclooxygenase-2 (COX-2) constitutively expressed?

Brain, kidney, and bone Signup and view all the answers

What function in the body do prostaglandins control?

Uterine contractions Signup and view all the answers

What is the primary action of non-steroidal anti-inflammatory drugs (NSAIDs)?

Inhibiting the cyclooxygenase enzymes Signup and view all the answers

Which compound is synthesized via the cyclooxygenase pathway?

Thromboxanes Signup and view all the answers

Which pathway forms leukotrienes or lipoxins depending on the tissue?

Lipoxygenase pathway Signup and view all the answers

What do all non-steroidal anti-inflammatory drugs (NSAIDs) share in terms of therapeutic actions and adverse effects?

Anti-inflammatory, analgesic, and antipyretic actions Signup and view all the answers