Podcast
Questions and Answers
What is the main purpose of inflammation in the body?
What is the main purpose of inflammation in the body?
- To activate T lymphocytes
- To maintain joint destruction
- To produce proinflammatory cytokines
- To inactivate or destroy invading organisms (correct)
Which cells initiate an inflammatory attack in rheumatoid arthritis (RA)?
Which cells initiate an inflammatory attack in rheumatoid arthritis (RA)?
- White blood cells (WBCs) (correct)
- T lymphocytes
- Monocytes and macrophages
- B lymphocytes
What do T lymphocytes recruit and activate during an inflammatory attack in RA?
What do T lymphocytes recruit and activate during an inflammatory attack in RA?
- Proinflammatory cytokines
- Monocytes and macrophages (correct)
- Rheumatoid factor and autoantibodies
- B lymphocytes
Which substances are secreted by monocytes and macrophages during inflammation in RA?
Which substances are secreted by monocytes and macrophages during inflammation in RA?
What is the primary goal of pharmacotherapy for RA?
What is the primary goal of pharmacotherapy for RA?
What is the role of prostaglandins in the body?
What is the role of prostaglandins in the body?
Which enzyme is responsible for the physiologic production of prostanoids?
Which enzyme is responsible for the physiologic production of prostanoids?
What is the primary precursor of the prostaglandins and related compounds?
What is the primary precursor of the prostaglandins and related compounds?
Which pathway leads to the synthesis of all eicosanoids with ring structures?
Which pathway leads to the synthesis of all eicosanoids with ring structures?
Where is Cyclooxygenase-2 (COX-2) constitutively expressed?
Where is Cyclooxygenase-2 (COX-2) constitutively expressed?
What are the primary functions of prostaglandins in the body?
What are the primary functions of prostaglandins in the body?
How do non-steroidal anti-inflammatory drugs (NSAIDs) act?
How do non-steroidal anti-inflammatory drugs (NSAIDs) act?
At which site is Cyclooxygenase-2 (COX-2) expression increased during states of inflammation?
At which site is Cyclooxygenase-2 (COX-2) expression increased during states of inflammation?
What is the primary action of non-steroidal anti-inflammatory drugs (NSAIDs)?
What is the primary action of non-steroidal anti-inflammatory drugs (NSAIDs)?
What is the effect of intradermal, intravenous, or intra-arterial injections of small amounts of prostaglandins?
What is the effect of intradermal, intravenous, or intra-arterial injections of small amounts of prostaglandins?
What is the shared therapeutic action of all non-steroidal anti-inflammatory drugs (NSAIDs)?
What is the shared therapeutic action of all non-steroidal anti-inflammatory drugs (NSAIDs)?
What is the role of inflammation in the body?
What is the role of inflammation in the body?
Which cells are involved in initiating an inflammatory attack in rheumatoid arthritis (RA)?
Which cells are involved in initiating an inflammatory attack in rheumatoid arthritis (RA)?
What substances are secreted by monocytes and macrophages during inflammation in RA?
What substances are secreted by monocytes and macrophages during inflammation in RA?
What is the primary goal of pharmacotherapy for rheumatoid arthritis (RA)?
What is the primary goal of pharmacotherapy for rheumatoid arthritis (RA)?
What is the main purpose of prostaglandins in the body?
What is the main purpose of prostaglandins in the body?
Which enzyme is responsible for the physiologic production of prostaglandins and related compounds?
Which enzyme is responsible for the physiologic production of prostaglandins and related compounds?
What is the primary precursor of the prostaglandins and related compounds?
What is the primary precursor of the prostaglandins and related compounds?
Which enzyme is responsible for the physiologic production of prostanoids?
Which enzyme is responsible for the physiologic production of prostanoids?
Where is Cyclooxygenase-2 (COX-2) constitutively expressed?
Where is Cyclooxygenase-2 (COX-2) constitutively expressed?
What is the effect of intradermal, intravenous, or intra-arterial injections of small amounts of prostaglandins?
What is the effect of intradermal, intravenous, or intra-arterial injections of small amounts of prostaglandins?
Which pathway leads to the synthesis of all eicosanoids with ring structures?
Which pathway leads to the synthesis of all eicosanoids with ring structures?
What is the shared therapeutic action of all non-steroidal anti-inflammatory drugs (NSAIDs)?
What is the shared therapeutic action of all non-steroidal anti-inflammatory drugs (NSAIDs)?
What is the main purpose of inflammation in the body?
What is the main purpose of inflammation in the body?
What is the role of prostaglandins in the body?
What is the role of prostaglandins in the body?
At which site is Cyclooxygenase-2 (COX-2) expression increased during states of inflammation?
At which site is Cyclooxygenase-2 (COX-2) expression increased during states of inflammation?
What substances are secreted by monocytes and macrophages during inflammation in RA?
What substances are secreted by monocytes and macrophages during inflammation in RA?
