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Inflammation and Anti-Inflammatory Drugs (Part-1)

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Inflammation and Anti-Inflammatory Drugs (Part-1)

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Questions and Answers

What is the primary goal of inflammation in response to tissue injury?

To promote tissue damage and impair quality of life

To activate the immune system and cause inflammatory diseases

To reduce the production of prostanoid mediators

To eliminate harmful agents and promote healing (correct)

Which of the following is NOT a derivative of the class of NSAIDs that includes acetic acid?

Indomethacin

Diclofenac

Aspirin (correct)

Ibuprofen

What is the primary mechanism by which NSAIDs reduce prostaglandin synthesis?

By activating the production of cyclooxygenase enzymes

By inhibiting cyclooxygenase enzymes (correct)

By inhibiting the production of arachidonic acid

By stimulating the production of leukotriene

What is the consequence of excessive immune activation in inflammatory diseases?

Joint damage and impaired quality of life Signup and view all the answers

Which of the following is a selective COX-2 inhibitor?

Celecoxib Signup and view all the answers

What is the main difference between NSAIDs in terms of their safety and efficacy?

Their selectivity for COX-1 or COX-2 enzymes Signup and view all the answers

Which of the following is responsible for the anti-inflammatory effects of NSAIDs?

Inhibition of COX-2 Signup and view all the answers

What is the primary mechanism by which aspirin inhibits COX activity?

Irreversible inhibition of COX through acetylation Signup and view all the answers

Which of the following is a result of NSAIDs' antipyretic action?

Resetting the body's temperature regulation mechanism Signup and view all the answers

What is the primary effect of PGE2 on pain sensation?

Sensitization of nerve endings to inflammatory mediators Signup and view all the answers

What is a potential benefit of combining NSAIDs with opioids in malignancy-related pain management?

Opioid-sparing effect Signup and view all the answers

At what doses do salicylates, like aspirin, offer both pain relief and anti-inflammatory effects?

High doses Signup and view all the answers