Pharmacology: Drug Therapy of Acid-related GIT Disorders-1
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Questions and Answers

What is the main line of treatment for gastric ulcers?

  • Cytoprotective drugs
  • Anti-secretory drugs (correct)
  • Antacids
  • Anti H.pylori

    • Which drug class is rarely needed in the treatment of duodenal ulcers?

  • Cytoprotective drugs (correct)
  • Mucosal protective drugs
  • Anti H.pylori
  • Antacids

    • What is the target site of action for H2 blockers?

  • Enterochromaffin-like Cell
  • Gastrin receptor
  • Parietal cell (correct)
  • Proton pump

    • What is the mechanism of action of proton pump inhibitors (PPIs)?

    <p>Inhibition of H+/K+ ATPase enzyme</p> Signup and view all the answers

    Why are proton pump inhibitors (PPIs) given on an empty stomach?

    <p>To increase bioavailability</p> Signup and view all the answers

    Which drug should be administered about 30 minutes before meals due to its activation requirement in acidic conditions?

    <p>PPIs</p> Signup and view all the answers

    What is the mechanism of action of Vonoprazan?

    <p>Competes with K+ to inhibit H+/K+ ATPase</p> Signup and view all the answers

    What is a potential adverse effect of long-term Proton Pump Inhibitor (PPI) use?

    <p>Vitamin B12 deficiency</p> Signup and view all the answers

    How do Potassium-Competitive Acid Blockers (P-CABs) compare to PPIs in terms of onset of therapeutic response?

    <p>P-CABs have a more rapid onset compared to PPIs</p> Signup and view all the answers

    How are P-CABs advantageous over PPIs in relation to food intake?

    <p>P-CABs are not affected by food intake</p> Signup and view all the answers

    Which enzyme is involved in the metabolism of Proton Pump Inhibitors (PPIs) in the liver?

    <p>CYP2C19</p> Signup and view all the answers

    What is the most common type of peptic ulcer?

    <p>Duodenal ulcer caused by increased HCl and H.Pylori infection</p> Signup and view all the answers

    Which of the following drugs is used to treat infection with H.pylori?

    <p>Bismuth</p> Signup and view all the answers

    What is the main target of drugs used in the management of acid-related GIT disorders?

    <p>K+/H+ ATPase</p> Signup and view all the answers

    What is the role of proton pump inhibitors (PPIs) in treating peptic ulcers?

    <p>Neutralization of secreted acid</p> Signup and view all the answers

    Which condition is characterized by increased HCl secretion due to a gastrin-producing tumor?

    <p>Zollinger-Ellison syndrome</p> Signup and view all the answers

    How are patients with an infection of H.Pylori usually treated?

    <p>Antibiotics plus antisecretory drugs, sometimes with bismuth</p> Signup and view all the answers

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