Pharmacology: Drug Therapy of Acid-related GIT Disorders-1

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What is the main line of treatment for gastric ulcers?

Cytoprotective drugs

Anti-secretory drugs (correct)

Antacids

Anti H.pylori

Which drug class is rarely needed in the treatment of duodenal ulcers?

Cytoprotective drugs (correct)

Mucosal protective drugs

Anti H.pylori

Antacids

What is the target site of action for H2 blockers?

Enterochromaffin-like Cell

Gastrin receptor

Parietal cell (correct)

Proton pump

What is the mechanism of action of proton pump inhibitors (PPIs)?

Inhibition of H+/K+ ATPase enzyme Signup and view all the answers

Why are proton pump inhibitors (PPIs) given on an empty stomach?

To increase bioavailability Signup and view all the answers

Which drug should be administered about 30 minutes before meals due to its activation requirement in acidic conditions?

PPIs Signup and view all the answers

What is the mechanism of action of Vonoprazan?

Competes with K+ to inhibit H+/K+ ATPase Signup and view all the answers

What is a potential adverse effect of long-term Proton Pump Inhibitor (PPI) use?

Vitamin B12 deficiency Signup and view all the answers

How do Potassium-Competitive Acid Blockers (P-CABs) compare to PPIs in terms of onset of therapeutic response?

P-CABs have a more rapid onset compared to PPIs Signup and view all the answers

How are P-CABs advantageous over PPIs in relation to food intake?

P-CABs are not affected by food intake Signup and view all the answers

Which enzyme is involved in the metabolism of Proton Pump Inhibitors (PPIs) in the liver?

CYP2C19 Signup and view all the answers

What is the most common type of peptic ulcer?

Duodenal ulcer caused by increased HCl and H.Pylori infection Signup and view all the answers

Which of the following drugs is used to treat infection with H.pylori?

Bismuth Signup and view all the answers

What is the main target of drugs used in the management of acid-related GIT disorders?

K+/H+ ATPase Signup and view all the answers

What is the role of proton pump inhibitors (PPIs) in treating peptic ulcers?

Neutralization of secreted acid Signup and view all the answers

Which condition is characterized by increased HCl secretion due to a gastrin-producing tumor?

Zollinger-Ellison syndrome Signup and view all the answers

How are patients with an infection of H.Pylori usually treated?

Antibiotics plus antisecretory drugs, sometimes with bismuth Signup and view all the answers

Pharmacology: Drug Therapy of Acid-related GIT Disorders-1

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