Pharmacology Lecture: Drug Therapy of Acid-related GIT Disorders-1

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Questions and Answers

Which enzyme is involved in the metabolism of PPIs?

  • CYP1A2
  • CYP3A4 (correct)
  • CYP2D6
  • CYP2C9

What adverse effect on the gastrointestinal tract can be caused by PPIs?

  • Nausea (correct)
  • Constipation
  • Flatulence
  • Heartburn

Which condition in animals has been associated with hypochlorhydria caused by PPIs?

  • Pneumonia
  • Gastric tumors (correct)
  • Kidney stones
  • Rickets

What is one of the adverse effects on the central nervous system that can result from PPI use?

<p>Headache (D)</p> Signup and view all the answers

What is the mechanism of action of Vonoprazan?

<p>Inhibits H+/K+ ATPase by forming an ionic bond (A)</p> Signup and view all the answers

What advantage do P-CABs have over PPIs in terms of food intake?

<p>Absorption is not affected by food intake (A)</p> Signup and view all the answers

How do P-CABs compare to PPIs in terms of control of nocturnal symptoms?

<p>P-CABs have better control (A)</p> Signup and view all the answers

Which of the following PPI adverse effects affect the Central Nervous System?

<p>Headache (C)</p> Signup and view all the answers

What is one of the adverse effects on the Central Nervous System resulting from PPI use?

<p>Headache (A)</p> Signup and view all the answers

Which of the following is an advantage of P-CABs over PPIs in terms of therapeutic response onset?

<p>Rapid onset of therapeutic response within 2 hours (B)</p> Signup and view all the answers

What is one notable advantage of P-CABs over PPIs regarding food intake?

<p>Not affected by food intake (A)</p> Signup and view all the answers

How do P-CABs compare to PPIs regarding Vitamin B12 deficiency?

<p>No effect on Vitamin B12 levels (B)</p> Signup and view all the answers

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