12 Questions
Which of the following criteria would NOT prompt pharmacological treatment for osteoporosis?
T-score of -2.0 at the femoral neck
How do most osteoporosis medications work?
By inhibiting osteoclastic bone resorption
What is the primary mechanism of action of antiresorptive medications?
Inhibiting osteoclastic bone resorption
Which medication is considered the most cost-effective option and is often the first-line agent used for osteoporosis treatment?
Alendronate
How are oral bisphosphonates typically administered?
Once daily on an empty stomach
Which type of medication primarily stimulates osteoblastic bone formation?
Teriparatide
What is the main reason oral bisphosphonates should be taken on an empty stomach?
To improve oral absorption
Which medication primarily inhibits osteoclastic bone resorption?
Ibandronate
What is the purpose of anabolic drugs in osteoporosis treatment?
To stimulate osteoblastic bone formation
Which type of medication has variable effects on bone resorption?
Teriparatide
What is the mode of administration for intravenous bisphosphonate preparations like zoledronate?
Once monthly
What condition would prompt pharmacological treatment for osteoporosis according to the given criteria?
T-score of -3.0 at the femoral neck
Study Notes
Osteoporosis Treatment
- A T-score of -2.5 or lower in the absence of a fracture would prompt pharmacological treatment for osteoporosis.
- Most osteoporosis medications work by either inhibiting bone resorption or stimulating bone formation.
- Antiresorptive medications primarily work by inhibiting osteoclastic bone resorption.
- Alendronate is considered the most cost-effective option and is often the first-line agent used for osteoporosis treatment.
- Oral bisphosphonates are typically administered weekly or monthly.
- Anabolic medications, such as teriparatide, primarily stimulate osteoblastic bone formation.
- Oral bisphosphonates should be taken on an empty stomach to enhance absorption and reduce gastrointestinal side effects.
- Bisphosphonates primarily inhibit osteoclastic bone resorption.
- Anabolic drugs are used to stimulate bone formation and increase bone mineral density in osteoporosis treatment.
- Hormone replacement therapy has variable effects on bone resorption.
- Intravenous bisphosphonate preparations like zoledronate are administered via a 15-minute infusion once a year.
Test your knowledge of the criteria for pharmacological treatment for osteoporosis in postmenopausal women and men aged 50 years and over. Learn about the indications for treatment based on fragility fractures, DXA T-scores, low bone mineral density, and fracture probabilities.
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