5 Questions
What does potency refer to in pharmacology?
Potency refers to the concentration (EC 50) or dose (ED 50) of a drug required to produce 50% of that drug’s maximal effect.
What factors contribute to the potency of a drug?
The potency of a drug depends in part on the affinity (Kd-The concentration of drug that binds 50% of the receptors in the system) of receptors for binding the drug and in part on the efficiency with which drug-receptor interaction is coupled to response.
Why can some doses of drug A produce larger effects than any dose of drug B despite drug B being described as more pharmacologically potent?
Some doses of drug A can produce larger effects than any dose of drug B, despite the fact that we describe drug B as pharmacologically more potent, because drug A has a larger maximal efficacy.
How does the potency of drug A compare to that of drug B in Figure 2–15?
The pharmacologic potency of drug A in Figure 2–15 is less than that of drug B, a partial agonist because the EC 50 of A is greater than the EC 50 of B.
What is the importance of distinguishing between a drug’s potency and its efficacy in clinical use?
For clinical use, it is important to distinguish between a drug’s potency and its efficacy because the clinical effectiveness of a drug depends not on its potency (EC 50), but on its maximal efficacy and its ability to reach the.
Test your knowledge of pharmacologic potency and drug affinity with this quiz. Explore the concepts of EC50, ED50, and KD as you compare the potency of different drugs and understand their maximal effects.
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