Pharmacology Chapter 2 Board Review Questions: Drug Potency and Efficacy

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How do most drugs pass through the placenta?

Endocytosis

Active transport

Facilitated diffusion

Simple diffusion based on lipid solubility (correct)

How will the administration of drug B alter the effects of drug A?

Diminish the therapeutic effects of drug A

Have no impact on the effects of drug A

Enhance the therapeutic and adverse effects of drug A (correct)

Negate the effects of drug A

What is tissue redistribution particularly important for?

Thiopental (correct)

Enhancing drug absorption

Facilitating drug excretion

Increasing drug metabolism

What do agonists do in terms of tissue receptor sites?

Activate the receptor sites Signup and view all the answers

If a drug has a weakly acidic pKa of 3.4, what can be inferred about its behavior?

It will be mostly ionized in acidic environments Signup and view all the answers

What is the definition of ED50 for a drug?

The dose that gives 50% of the maximal effect Signup and view all the answers

Which route of administration provides the most predictable drug response?

Intravenous administration Signup and view all the answers

What drug characteristic increases the tendency of a drug to cross cell membranes?

Non-ionized and high lipid solubility Signup and view all the answers

If a drug has a pKa of 8.1 and is injected into tissue with a pH of 7.4, how much of the drug would be ionized in this tissue?

Under 50% Signup and view all the answers

What happens to a drug that is bound to plasma proteins?

It becomes inactive pharmacologically Signup and view all the answers

If a patient receives a maximal dose of drug A followed by an average dose of drug B, what percentage of drug A is bound to plasma protein?

50% Signup and view all the answers

Pharmacology Chapter 2 Board Review Questions: Drug Potency and Efficacy

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Questions and Answers

How do most drugs pass through the placenta?

How will the administration of drug B alter the effects of drug A?

What is tissue redistribution particularly important for?

What do agonists do in terms of tissue receptor sites?

If a drug has a weakly acidic pKa of 3.4, what can be inferred about its behavior?

What is the definition of ED50 for a drug?

Which route of administration provides the most predictable drug response?

What drug characteristic increases the tendency of a drug to cross cell membranes?

If a drug has a pKa of 8.1 and is injected into tissue with a pH of 7.4, how much of the drug would be ionized in this tissue?

What happens to a drug that is bound to plasma proteins?

If a patient receives a maximal dose of drug A followed by an average dose of drug B, what percentage of drug A is bound to plasma protein?

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