20 Questions
What is the main focus of pharmacokinetics?
Examining how drugs change in the body
According to Lord Kelvin, what does the ability to express something in numbers indicate?
Advanced knowledge of science
What does pharmacokinetics predict in relation to drug safety?
Human exposure from a planned regimen
What is the fundamental focus of dose response curves in pharmacology?
Observing drug response at receptor
What is the significance of measuring drug effects in numbers, according to Lord Kelvin?
Meagre and unsatisfactory knowledge
What is the fundamental parameter that represents drug elimination efficiency?
Clearance
Which pharmacokinetic parameter relates the amount of drug in the body to the drug plasma?
Volume of distribution
What is the typical unit for half-life?
h
Which type of kinetics describes drug elimination as usually exponential?
First-order kinetics
What does the apparent volume of distribution indicate for highly lipophilic drugs?
It is greater than 3 L/kg
What is the main component of the cell membrane that acts as a barrier for drug absorption?
Phospholipid bilayer
Which chemical characteristic of drugs facilitates their movement across membranes?
Lipophilicity
What type of molecules have a hydrophilic 'head' and a hydrophobic 'tail'?
Phospholipids
What is the role of transporters in drug disposition?
Facilitate drug distribution to tissues
What is the function of plasma protein binding in drug movement across membranes?
Affects the free concentration of drugs available for distribution
What does LogP measure in relation to a compound?
The concentration ratio of the compound in organic and aqueous phases
What does a negative LogP value indicate about a compound?
It has a high affinity for the aqueous phase
How do most drugs move across the cell membrane?
Through passive (simple) diffusion
What does Fick’s law of diffusion govern in simple diffusion?
The drug concentration gradient and permeability of the membrane
In relation to drug ionization, what are the lipid-soluble forms of weak acids and weak bases?
HA and H+
Test your knowledge of pharmacokinetics with this quiz covering key parameters, plasma-time curves, and compartmental pharmacokinetics. This quiz is perfect for pharmacy, pharmacology, and medical students, as well as anyone interested in learning about drug behavior in the body.
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