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Pharmacokinetics: Drug Transport and Disposition
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Pharmacokinetics: Drug Transport and Disposition

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Questions and Answers

What is the primary focus of pharmacokinetics?

  • How the body reacts to the drug
  • How the body eliminates the drug
  • How the drug affects the body
  • What the body does to the drug (correct)
  • What type of transport is involved in the movement of large ions?

  • Ion-pair transport (correct)
  • Passive diffusion
  • Convection transport
  • Active transport
  • What is the purpose of Phase I drug metabolism reactions?

  • To convert drugs into inactive or less active forms (correct)
  • To improve the absorption of the drug
  • To increase the potency of the drug
  • To increase the excretion of the drug
  • What is the result of a drug being in an acidic environment if it is an acidic drug?

    <p>It becomes non-ionized and lipid-soluble</p> Signup and view all the answers

    What is the term for the reversible transfer of a drug from the systemic circulation to the site of action and other compartments?

    <p>Distribution</p> Signup and view all the answers

    What is the term for the process by which a drug is released from its dosage form into its solution form?

    <p>Liberation</p> Signup and view all the answers

    Which scientist is known as the 'Father of Chemotherapy'?

    <p>Paul Ehrlich</p> Signup and view all the answers

    What is the name of the first antibiotic discovered by Alexander Fleming?

    <p>Penicillin</p> Signup and view all the answers

    What is the function of antiseptics?

    <p>To destroy pathogenic microorganisms locally</p> Signup and view all the answers

    What is the effect of increasing the carbon atom chain length on antibacterial property up to C8?

    <p>Antibacterial property increases</p> Signup and view all the answers

    What is the effect of branching on antibacterial property?

    <p>Antibacterial property decreases</p> Signup and view all the answers

    What is the term for substances that destroy or inhibit the growth of microorganisms that cause infection?

    <p>Anti-infectives</p> Signup and view all the answers

    What is the functional group attached to two carbon atoms in a sulfone?

    <p>Sulfonyl</p> Signup and view all the answers

    What is the primary mechanism of action of dapsone?

    <p>Inhibition of folate synthesis</p> Signup and view all the answers

    Which of the following conditions is dapsone commonly used to treat?

    <p>Leprosy</p> Signup and view all the answers

    What is the recommended combination therapy for initial treatment of lepromatous leprosy?

    <p>Dapsone, rifampin, and clofazimine</p> Signup and view all the answers

    Which nitrofuran is used to treat American sleeping sickness?

    <p>Nifurtimox</p> Signup and view all the answers

    What type of diarrhea is furazolidone commonly used to treat?

    <p>Bacterial and protozoal diarrhea</p> Signup and view all the answers

    What is the mechanism of action of Silver Nitrate?

    <p>It reacts with the –SH of enzymes and other proteins by forming R-SHg-R'</p> Signup and view all the answers

    What is the use of Silver Sulfadiazine?

    <p>It is used as a burn ointment</p> Signup and view all the answers

    What is the term for the combination of sulfamethoxazole and trimethoprim?

    <p>Co-trimoxazole</p> Signup and view all the answers

    What is the reversible effect of Mercury on enzymes and proteins?

    <p>It is reversible by thiol-containing compounds such as Cysteine and Dimeraprol</p> Signup and view all the answers

    Which of the following cells do not synthesize folic acid?

    <p>Mammalian cells</p> Signup and view all the answers

    What is the mechanism of action of trimethoprim?

    <p>Inhibiting the reduction of dihydrofolic acid to tetrahydrofolic acid</p> Signup and view all the answers

    What is Chlormerodrin Hg-197?

    <p>A radio-labelled form of Chlormerodrin, an organomercury compound</p> Signup and view all the answers

    What is the alternative drug to trimethoprim/sulfamethoxazole for the treatment of Pneumocystis carinii infection?

    <p>Pentamidine</p> Signup and view all the answers

    What is the common property of Heavy Metals with oligodynamic properties?

    <p>They can inhibit microorganisms in few concentrations</p> Signup and view all the answers

    What is Merthiolate (Thimerosal)?

    <p>An organic Mercurial</p> Signup and view all the answers

    What is the primary use of trimethoprim?

    <p>Treatment of bladder infections</p> Signup and view all the answers

    What is the effect of trimethoprim on bacterial DNA synthesis?

    <p>Inhibition of DNA synthesis</p> Signup and view all the answers

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