Questions and Answers
Parkinson's disease is the deficit of a 1.___________ neurotransmitter.
dopamine
Match the types of dopamine agonists with their examples:
Direct-acting Dopamine Receptor Agonists = Ropinirole Indirect-acting Dopaminergic = Rasagiline
What are the side effects of rasagiline?
Dizziness, Nausea, Insomnia
What are the side effects of ropinirole?
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Direct-acting dopamine receptor agonists are effective in the 1._______ stages of Parkinson's disease.
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Indirect-acting dopaminergic drugs such as MAO inhibitors are given to 1._____________________ the needed dose of levodopa.
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Indirect-acting dopaminergic drugs such as MAO inhibitors enzymes main purpose is the breakdown of 1._______________________.
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Selegiline is used alone or in conjunction with 1._______________________ in 2.___________ stages of the disease to help with symptom fluctuations.
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1.________________ stimulates dopamine receptors in the brain.
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When giving 1._____________ watch out for somnolence which means the patient can fall asleep during regular activities.
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What are the side effects of selegiline? (Select all that apply)
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1.____________ will affect the activity of any drug utilizing the cytochrome p450 enzymes system.
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What are some adverse effects of ropinirole? (Select all that apply)
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1.______________ duration is 8 hours.
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Do not consume large amounts of tyramine containing foods when taking 1.________________.
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Which of the following medications would be contraindicated for Sally to take to treat her Parkinson's symptoms?
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Which should be included when educating clients about antiparkinson medications? (Select all that apply.)
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Study Notes
Parkinson's Disease Overview
- Parkinson's disease results from a deficiency of dopamine, a vital neurotransmitter in the brain.
Antiparkinson Drugs
- Direct-acting dopamine receptor agonists include Ropinirole.
- Indirect-acting dopaminergic medications include Rasagiline.
Side Effects of Antiparkinson Medications
- Rasagiline can cause dizziness, nausea, and insomnia.
- Ropinirole may lead to edema, syncope (fainting), and fatigue.
Effectiveness of Antiparkinson Drugs
- Direct-acting dopamine receptor agonists are most effective in the early stages of Parkinson's disease.
- Indirect-acting dopaminergic drugs, like MAO inhibitors, are used to decrease the required dose of levodopa.
Mechanism of Indirect-acting Dopaminergic Drugs
- MAO inhibitors primarily function to break down catecholamines in the body.
Selegiline Usage
- Selegiline can be used alone or in conjunction with carbidopa-levodopa during the early stages of Parkinson's to manage symptom fluctuations.
- It stimulates dopamine receptors in the brain.
Monitoring Ropinirole
- Ropinirole may cause somnolence, increasing the risk of patients falling asleep during daily activities.
- It can affect any drug utilizing the cytochrome P450 enzyme system.
Adverse Effects and Education
- Common adverse effects of Ropinirole include syncope, gastrointestinal upset, and edema.
- Ropinirole has a duration of action of approximately 8 hours.
- Patients taking Selegiline should avoid large amounts of tyramine-containing foods to prevent adverse reactions.
Contraindications and Patient Education
- Ropinirole is contraindicated for patients with a history of atrial fibrillation, especially when taking anticoagulants like warfarin.
- Patient education should include:
- Expect a decrease in Parkinson's symptoms as a therapeutic response.
- Take medications exactly as prescribed to maintain consistent blood levels.
- Do not abruptly discontinue any prescribed medication to avoid withdrawal symptoms.
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Description
This quiz covers the key aspects of Parkinson's disease, including its causes, symptoms, and treatment options. Learn about direct and indirect-acting antiparkinson medications, their side effects, and mechanisms of action. Test your knowledge on how these medications help manage the disease effectively.
