Podcast
Questions and Answers
What is the mechanism of action for decongestants?
What is the mechanism of action for decongestants?
Decongestants reduce nasal congestion by stimulating the alpha-adrenergic receptor sites on vascular smooth muscles, causing the dilated arterioles to constrict and reducing the blood flow to engorged nasal vascular beds.
What is the difference between pseudoephedrine and ephedrine in terms of adrenergic receptor activity?
What is the difference between pseudoephedrine and ephedrine in terms of adrenergic receptor activity?
Pseudoephedrine has only 25% of the adrenergic receptor activity of ephedrine.
Why was phenylpropanolamine (PPA) discontinued from pharmaceutical products in 2000?
Why was phenylpropanolamine (PPA) discontinued from pharmaceutical products in 2000?
PPA was discontinued due to the risk of haemorrhagic stroke associated with its use, particularly among women.
What are the serious manifestations of decongestant toxicity?
What are the serious manifestations of decongestant toxicity?
Name four compounds that are powerful alpha2-adrenergic receptor stimulants.
Name four compounds that are powerful alpha2-adrenergic receptor stimulants.
What are the clinical toxic features associated with decongestant toxicity?
What are the clinical toxic features associated with decongestant toxicity?
What are the signs and symptoms of chronic overuse of imidazoline decongestants?
What are the signs and symptoms of chronic overuse of imidazoline decongestants?
What is the antidote for acetaminophen poisoning?
What is the antidote for acetaminophen poisoning?
What is the most common drug involved in overdose and the second most common cause of liver failure in the U.S.?
What is the most common drug involved in overdose and the second most common cause of liver failure in the U.S.?
How does chronic use or large doses of acetaminophen lead to hepatotoxic sequelae?
How does chronic use or large doses of acetaminophen lead to hepatotoxic sequelae?
What is the recommended treatment for highly elevated hypertension caused by phenylpropanolamine overdose?
What is the recommended treatment for highly elevated hypertension caused by phenylpropanolamine overdose?
What is the mechanism by which N-acetylcysteine (NAC) acts as an antidote for acetaminophen poisoning?
What is the mechanism by which N-acetylcysteine (NAC) acts as an antidote for acetaminophen poisoning?
What are the potential psychiatric disturbances reported after ingestion of phenylpropanolamine, particularly in children?
What are the potential psychiatric disturbances reported after ingestion of phenylpropanolamine, particularly in children?
What is the primary cause of hepatotoxic sequelae in chronic use or large doses of acetaminophen?
What is the primary cause of hepatotoxic sequelae in chronic use or large doses of acetaminophen?
How does sodium bicarbonate administration help in the management of acetyl salicylic acid toxicity?
How does sodium bicarbonate administration help in the management of acetyl salicylic acid toxicity?
What are the potential adverse effects of imidazoline decongestants when used in combination with other sympathomimetics?
What are the potential adverse effects of imidazoline decongestants when used in combination with other sympathomimetics?
What should be monitored in severely symptomatic patients with phenylpropanolamine overdose?
What should be monitored in severely symptomatic patients with phenylpropanolamine overdose?
What is the recommended treatment for refractory cases of seizures, agitation, and psychosis caused by phenylpropanolamine overdose?
What is the recommended treatment for refractory cases of seizures, agitation, and psychosis caused by phenylpropanolamine overdose?
