Non-Steroidal Anti-Inflammatory Drugs Quiz
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Questions and Answers

Which of the following is true about Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)?

  • They have a low protein binding capacity
  • They are contained only in prescription combination drugs
  • They are among the top 25 substances associated with the largest number of fatalities (correct)
  • They are not commonly used and prescribed medications

    • What is the estimated prescription rate for NSAIDs in patients with rheumatologic diseases?

  • One in four
  • One in three
  • One in ten
  • One in seven (correct)

    • Which statement is true regarding the distribution of most NSAIDs in the body?

  • They obtain synovial fluid concentrations equal to or less than their plasma concentration
  • They achieve synovial fluid concentrations equal to or greater than their plasma concentrations (correct)
  • They have a small volume of distribution
  • They do not penetrate inflamed joints

    • What is the typical bioavailability of most NSAIDs?

    <p>Above 80%</p> Signup and view all the answers

    What percentage of protein binding do most NSAIDs have?

    <p>Between 95% and 99%</p> Signup and view all the answers

    Which type of drugs are Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) considered to be?

    <p>Prescription and nonprescription drugs</p> Signup and view all the answers

    Which is the most common adverse effect of NSAID use?

    <p>Gastrointestinal toxicity</p> Signup and view all the answers

    Which NSAID shows a trend toward minimal cardiovascular risk?

    <p>Naproxen</p> Signup and view all the answers

    What is the plasma elimination half-life range for piroxicam during therapeutic dosing?

    <p>50 to 60 hours</p> Signup and view all the answers

    Which NSAID undergoes extensive first-pass metabolism with an oral bioavailability of about 50%?

    <p>Diclofenac</p> Signup and view all the answers

    What is the main route of excretion for most NSAIDs?

    <p>Renal excretion of metabolites</p> Signup and view all the answers

    Which NSAID is excreted 10% to 20% unchanged in the urine?

    <p>Ketorolac</p> Signup and view all the answers

    What happens when the plasma protein binding of naproxen becomes saturated?

    <p>The free drug concentration increases more rapidly than the total drug concentration.</p> Signup and view all the answers

    What is the effect of overdoses of oral ibuprofen on its elimination half-life?

    <p>It does not appear to prolong its elimination half-life.</p> Signup and view all the answers

    What are the rare moderate and severe findings in NSAID overdose?

    <p>Coma, seizures, metabolic acidosis, rhabdomyolysis</p> Signup and view all the answers

    What is the initial manifestation of symptoms after ingesting nonselective NSAIDs?

    <p>Gastrointestinal symptoms</p> Signup and view all the answers

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