Opioid Analgesic Drugs Overview

Which of the following statements about opioid analgesic drugs is true?

They are CNS depressants, potent analgesics for all types of pain except itching, and prolonged use leads to addiction

Which of the following is a natural alkaloid opioid agonist?

Morphine

What is the main constituent of the juice derived from the unripe capsule of the opium plant?

Morphine

Which of the following is a mixed agonist-antagonist opioid?

Pentazocine Signup and view all the answers

What is the bioavailability of morphine when taken orally?

25% Signup and view all the answers

Where is morphine conjugated and what is the active form?

Liver, Morphine-6-Conjugate (active) Signup and view all the answers

What is the main difference between opioid agonists and mixed agonist-antagonist opioids?

Opioid agonists are addictive while mixed agonist-antagonists are not. Signup and view all the answers

Which natural alkaloid is characterized by having negligible CNS action and being spasmolytic on smooth muscles?

Papaverine Signup and view all the answers

What is the function of (Morphine - 6- Conjugate) in the body?

It is the active form of morphine. Signup and view all the answers

Which opioid agonist is known for its high oral bioavailability and subsequent use via oral administration?

Codeine Signup and view all the answers

How is morphine predominantly excreted from the body?

Unchanged in urine Signup and view all the answers

Which opioid drug is a synthetic agonist with a higher risk of addiction compared to natural alkaloids?

Fentanyl Signup and view all the answers

Which type of opioid agonist is known for being both analgesic and spasmogenic on smooth muscles, as well as causing euphoria?

Natural Opium alkaloids Signup and view all the answers

What is the primary reason for the oral bioavailability of morphine being only 25%?

Poor absorption from the gut Signup and view all the answers

Which opioid drug is classified as a mixed agonist antagonist opioid?

Meperidine Signup and view all the answers

What is a notable characteristic of Papaverine among natural opium alkaloids?

Negligible CNS action Signup and view all the answers

In what form is morphine predominantly excreted in the urine?

Unchanged Signup and view all the answers

Which synthetic opioid agonist is known to have a higher risk of addiction compared to morphine?

Methadone Signup and view all the answers

Which of the following statements about the pharmacokinetics of morphine is incorrect?

It is primarily excreted unchanged in the urine, with minimal excretion in other bodily fluids. Signup and view all the answers

Which of the following statements regarding the classification of opioid analgesics is true?

Butorphanol is a mixed agonist-antagonist opioid, acting as an agonist at mu-opioid receptors and an antagonist at kappa-opioid receptors. Signup and view all the answers

Which of the following statements about the effects of natural opium alkaloids is incorrect?

Papaverine acts as a spasmolytic agent on smooth muscles. Signup and view all the answers

Which of the following statements regarding the effects of opioid analgesic drugs is correct?

They are potent analgesics for most types of pain, except itching, and prolonged use can lead to addiction. Signup and view all the answers

Which of the following statements about the excretion of morphine is true?

Morphine and its active metabolite are excreted in urine, saliva, bile, milk, and gastric fluid. Signup and view all the answers

Which of the following statements about the pharmacokinetics of morphine is correct?

Morphine is adequately absorbed from the gut, but has low oral bioavailability due to extensive first-pass metabolism in the liver. Signup and view all the answers

Opioid Analgesic Drugs Overview

Questions and Answers

Which of the following statements about opioid analgesic drugs is true?

Which of the following is a natural alkaloid opioid agonist?

What is the main constituent of the juice derived from the unripe capsule of the opium plant?

Which of the following is a mixed agonist-antagonist opioid?

What is the bioavailability of morphine when taken orally?

Where is morphine conjugated and what is the active form?

What is the main difference between opioid agonists and mixed agonist-antagonist opioids?

Which natural alkaloid is characterized by having negligible CNS action and being spasmolytic on smooth muscles?

What is the function of (Morphine - 6- Conjugate) in the body?

Which opioid agonist is known for its high oral bioavailability and subsequent use via oral administration?

How is morphine predominantly excreted from the body?

Which opioid drug is a synthetic agonist with a higher risk of addiction compared to natural alkaloids?

Which type of opioid agonist is known for being both analgesic and spasmogenic on smooth muscles, as well as causing euphoria?

What is the primary reason for the oral bioavailability of morphine being only 25%?

Which opioid drug is classified as a mixed agonist antagonist opioid?

What is a notable characteristic of Papaverine among natural opium alkaloids?

In what form is morphine predominantly excreted in the urine?

Which synthetic opioid agonist is known to have a higher risk of addiction compared to morphine?

Which of the following statements about the pharmacokinetics of morphine is incorrect?

Which of the following statements regarding the classification of opioid analgesics is true?

Which of the following statements about the effects of natural opium alkaloids is incorrect?

Which of the following statements regarding the effects of opioid analgesic drugs is correct?

Which of the following statements about the excretion of morphine is true?

Which of the following statements about the pharmacokinetics of morphine is correct?

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