10 Questions
What is the function of PCNA (proliferating cell nuclear antigen) in DNA replication?
It acts as a scaffold to recruit proteins for DNA replication
Which gene is suitable to identify patients with head and neck squamous cell carcinoma at risk for local and loco regional recurrence?
TP53
What is the purpose of the American Joint Committee on Cancer tumor-node-metastases staging system for oral cancer?
To reflect prognosis prior to treatment
What is the maximum to minimum order of aggressive behavior in high-risk types of basal cell carcinoma (BCC)?
Morphea-form > Infiltrative > Superficial > Micronodular
What is the most common cause of squamous cell carcinoma?
UV solar radiation
What is a clinical feature of squamous cell carcinoma?
Lip paresthesia
Where do most keratoacanthomas occur?
On sun-exposed areas
What is the most characteristic feature of keratoacanthoma lesions?
Elevated normal adjacent epithelium
What is the gender distribution of keratoacanthoma occurrences?
Twice as frequent in men
Which factor is implicated as an etiologic factor for keratoacanthoma?
Immunocompromised status
Test your knowledge on oncogenes, proto-oncogenes and tumor suppressor genes, and their association with head and neck cancer and squamous cell carcinoma (SCC). Identify the genes encoding for growth factors, growth factor receptors, protein kinases, signal transducers, and nuclear phosphoproteins involved in cancer development.
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