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Oncogenes and Tumor Suppressor Genes

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Questions and Answers

Which statement best describes oncogenes?

Oncogenes are mutated forms of proto-oncogenes that cause overactive stimulatory proteins leading to excessive cell proliferation (correct)

Oncogenes are not related to cancer progression

Oncogenes are normal genes that slow down cell division and promote programmed cell death

Oncogenes are external factors in the environment such as tobacco, alcohol, and radiation

What is the role of tumor suppressor genes?

Tumor suppressor genes are mutated forms of oncogenes that cause overactive cell division

Tumor suppressor genes are external factors in the environment

Tumor suppressor genes slow down cell division or promote programmed cell death (correct)

Tumor suppressor genes promote excessive cell proliferation

What is the function of TP53, an important tumor suppressor gene?

TP53 causes overactive cell division

TP53 helps keep cell division under control (correct)

TP53 stimulates excessive cell proliferation

TP53 is unrelated to cell division

What factors can lead to cancer progression?

<p>All of the above</p> Signup and view all the answers

Which statement is true about the initiation and progression of cancer?

<p>It depends on both external factors and internal factors</p> Signup and view all the answers

Study Notes

Oncogenes are mutated forms of proto-oncogenes, which code for proteins that stimulate excessive cell division.
Oncogenes result in the overactivity of stimulatory proteins, leading to uncontrollable cell proliferation.
An example of an oncogene is not provided in the text.
Tumor suppressor genes, on the other hand, are normal genes that slow down cell division or trigger apoptosis, preventing uncontrolled cell growth.
TP53 is a specific example of a tumor suppressor gene, coding for the p53 protein that helps regulate cell division.
Factors that contribute to cancer progression include both external environmental factors, such as tobacco, alcohol, radiation, and infectious microbes, and internal factors, including aging, inherited mutations, and immune conditions.
The text suggests that these factors can act independently or in combination, leading to abnormal cell behavior and excessive proliferation.

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Description

Test your knowledge of oncogenes and tumor suppressor genes, which play crucial roles in regulating cell division and proliferation. Understand the differences between these two types of genes and their impact on cellular processes.