T1 L17: Randomised Control Trials: Vaccines (CB)

<p>Lack of research evidence suggesting a difference in efficacy</p> Signup and view all the answers

<p>As participants and funders/fundraisers</p> Signup and view all the answers

<p>Generate new theory</p> Signup and view all the answers

<p>Qualitative research</p> Signup and view all the answers

<p>To provide evidence for a causal association between exposure and outcome</p> Signup and view all the answers

<p>Efficacy refers to the performance of an intervention in ideal conditions, while effectiveness refers to its performance in real-life conditions</p> Signup and view all the answers

<p>To inform the design and conduct of the RCT</p> Signup and view all the answers

<p>A variable that influences both the dependent variable and independent variable causing a spurious association</p> Signup and view all the answers

<p>Randomisation ensures that confounders are equally distributed between intervention and control groups</p> Signup and view all the answers

<p>A study in which participants are randomly allocated between an intervention and a control group</p> Signup and view all the answers

<p>To assess the long-term effects of an intervention</p> Signup and view all the answers

<p>Altruism</p> Signup and view all the answers

<p>Concerns about vaccine safety</p> Signup and view all the answers

<p>Impact on future trial recruitment and consent processes</p> Signup and view all the answers

<p>To understand why parenting interventions appear to fail/sometimes increase vaccine refusal</p> Signup and view all the answers

<p>Participants wanted more information and to understand different perspectives</p> Signup and view all the answers

<p>Randomization</p> Signup and view all the answers

<p>Selection bias and observer/detection bias</p> Signup and view all the answers

<p>Qualitative research</p> Signup and view all the answers

<p>Confounding</p> Signup and view all the answers

<p>It ensures that all participants have an equal chance of receiving each intervention</p> Signup and view all the answers

<p>To eliminate bias and ensure a causal association between the intervention and outcome</p> Signup and view all the answers

<p>Systematic differences between baseline characteristics of groups that are compared</p> Signup and view all the answers

<p>Systematic differences in the way information is collected for the groups being studied</p> Signup and view all the answers

<p>Plausibility</p> Signup and view all the answers

<p>The extent to which the observed difference between groups can be correctly attributed to the intervention tested</p> Signup and view all the answers

<p>The extent to which outcomes observed in the study apply to people outside the sample included in the trial</p> Signup and view all the answers

<p>Randomized Controlled Trial (RCT)</p> Signup and view all the answers

<p>RCTs provide a more controlled environment</p> Signup and view all the answers

<p>Internal validity</p> Signup and view all the answers

<p>To provide evidence for causal association</p> Signup and view all the answers

<p>Increasing the sample size</p> Signup and view all the answers

<p>Selection bias</p> Signup and view all the answers

<p>To measure outcomes consistently</p> Signup and view all the answers

<p>Observer/detection bias</p> Signup and view all the answers

<p>Studies that observe and compare health outcomes without manipulating exposure</p> Signup and view all the answers

<p>The presence of factors that influence both vaccine behavior and health outcomes</p> Signup and view all the answers

<p>Flu vaccines had positive outcomes for elderly patients</p> Signup and view all the answers

<p>To adjust for the impact of confounding on the relationship between exposure and outcome</p> Signup and view all the answers

<p>A study design used to test both the efficacy and effectiveness of interventions</p> Signup and view all the answers

<p>To eliminate confounding variables and reduce bias</p> Signup and view all the answers

<p>Efficacy refers to testing interventions in controlled conditions, while effectiveness refers to testing interventions in real-life conditions</p> Signup and view all the answers

<p>Randomised controlled trial (RCT)</p> Signup and view all the answers

<p>To ensure equal distribution of confounding variables</p> Signup and view all the answers

<p>A variable that influences both the dependent and independent variables</p> Signup and view all the answers

<p>To assess the feasibility of conducting the RCT</p> Signup and view all the answers

<p>Confounding variable</p> Signup and view all the answers

<p>The extent to which the trial accurately measures the outcome of interest</p> Signup and view all the answers

<p>To prevent systematic differences between the intervention and control groups</p> Signup and view all the answers

<p>The lack of representativeness of the trial sample to the wider population</p> Signup and view all the answers

<p>The differences in outcome measurement between different groups in the trial</p> Signup and view all the answers

<p>To ensure that participants and observers are unaware of the treatment group assignments</p> Signup and view all the answers

<p>It helps to minimize bias in the measurement of outcomes</p> Signup and view all the answers

<p>To ensure that any differences in outcomes are due to the treatment and not the measurement method</p> Signup and view all the answers

<p>It can take different forms depending on the study design</p> Signup and view all the answers

<p>To minimize bias in the measurement of outcomes</p> Signup and view all the answers

<p>It helps to minimize bias in the measurement of outcomes</p> Signup and view all the answers