12 Questions
Which of the following nonbenzodiazepine hypnotics is a melatonin receptor agonist?
Ramelteon (Rozerem)
What is the mechanism of action of the orexin receptor antagonist suvorexant (Belsomra)?
It blocks the binding of orexin to the orexin A and orexin B receptors
Which of the following statements about the pharmacokinetics of nonbenzodiazepine hypnotics is correct?
They have short half-lives, ranging from 1 to 5.8 hours
Which of the following is NOT a nonbenzodiazepine hypnotic mentioned in the text?
Triazolam
What is the percentage of protein binding for zolpidem?
92%
What is the peak onset time for ramelteon after oral administration?
0.75 hours (range 0.5 to 1.0 hours)
What is the recommended initial dose of suvorexant?
10 mg taken 30 minutes before bedtime
Which drug should be preferred for patients with a history of drug or alcohol abuse?
Ramelteon
What is the maximum daily dose of zolpidem sublingual tablets for women and older patients?
1.75 mg
When should these nonbenzodiazepine drugs be taken according to patient education?
Immediately before bedtime
Which drug class includes medications used primarily for sedation during episodes of insomnia?
Nonbenzodiazepine gaba-ergics
What consequence can occur if patients combine these drugs with over-the-counter sleeping aids or alcohol?
Increased risk of side effects and complications
Learn about the pharmacodynamics of nonbenzodiazepine hypnotics which induce sleep by acting on the GABA receptor but not at the benzodiazepine site. Explore the four drugs in this class including zolpidem, zaleplon, eszopiclone, and ramelteon.
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