Nonbenzodiazepine Hypnotics Pharmacodynamics
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Questions and Answers

Which of the following nonbenzodiazepine hypnotics is a melatonin receptor agonist?

  • Zolpidem (Ambien)
  • Ramelteon (Rozerem) (correct)
  • Zaleplon (Sonata)
  • Eszopiclone (Lunesta)

    • What is the mechanism of action of the orexin receptor antagonist suvorexant (Belsomra)?

  • It blocks the binding of orexin to the GABA receptor
  • It blocks the binding of orexin to the benzodiazepine receptor
  • It blocks the binding of orexin to the melatonin receptor
  • It blocks the binding of orexin to the orexin A and orexin B receptors (correct)

    • Which of the following statements about the pharmacokinetics of nonbenzodiazepine hypnotics is correct?

  • They have long half-lives, ranging from 10 to 20 hours
  • They have short half-lives, ranging from 1 to 5.8 hours (correct)
  • They are not protein bound
  • They are slowly absorbed through oral administration

    • Which of the following is NOT a nonbenzodiazepine hypnotic mentioned in the text?

    <p>Triazolam</p> Signup and view all the answers

    What is the percentage of protein binding for zolpidem?

    <p>92%</p> Signup and view all the answers

    What is the peak onset time for ramelteon after oral administration?

    <p>0.75 hours (range 0.5 to 1.0 hours)</p> Signup and view all the answers

    What is the recommended initial dose of suvorexant?

    <p>10 mg taken 30 minutes before bedtime</p> Signup and view all the answers

    Which drug should be preferred for patients with a history of drug or alcohol abuse?

    <p>Ramelteon</p> Signup and view all the answers

    What is the maximum daily dose of zolpidem sublingual tablets for women and older patients?

    <p>1.75 mg</p> Signup and view all the answers

    When should these nonbenzodiazepine drugs be taken according to patient education?

    <p>Immediately before bedtime</p> Signup and view all the answers

    Which drug class includes medications used primarily for sedation during episodes of insomnia?

    <p>Nonbenzodiazepine gaba-ergics</p> Signup and view all the answers

    What consequence can occur if patients combine these drugs with over-the-counter sleeping aids or alcohol?

    <p>Increased risk of side effects and complications</p> Signup and view all the answers

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