Nonbenzodiazepine Hypnotics Pharmacodynamics
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Questions and Answers

What is the primary mechanism of action of nonbenzodiazepine hypnotics?

  • They act at the orexin receptors in the hypothalamus
  • They do not act at the GABA receptor, but at a different receptor site (correct)
  • They act at the benzodiazepine site of the GABA receptor
  • They act as melatonin receptor agonists

    • Which of the following is not a nonbenzodiazepine hypnotic?

  • Zolpidem
  • Zaleplon
  • Zopiclone (correct)
  • Eszopiclone

    • What is the primary mechanism of action of ramelteon?

  • It acts as a melatonin receptor agonist (correct)
  • It acts as an orexin receptor antagonist
  • It acts at the GABA receptor
  • It acts at the benzodiazepine site of the GABA receptor

    • What is the primary mechanism of action of suvorexant?

    <p>It blocks the binding of orexin to its receptors</p> Signup and view all the answers

    Which of the following nonbenzodiazepine hypnotics has the shortest half-life?

    <p>Zaleplon</p> Signup and view all the answers

    Which nonbenzodiazepine hypnotic has the highest protein binding?

    <p>Zolpidem</p> Signup and view all the answers

    What is the recommended initial dose of suvorexant for a patient not on a moderate CYP3A4 inhibitor?

    <p>10 mg</p> Signup and view all the answers

    What is the recommended dose of suvorexant for a patient who is on a moderate CYP3A4 inhibitor?

    <p>5 mg</p> Signup and view all the answers

    Which of the following is NOT a recommended dosing practice for the nonbenzodiazepine gaba-ergic drugs?

    <p>Take the medication as needed throughout the day</p> Signup and view all the answers

    Which of the following statements about ramelteon is correct?

    <p>Ramelteon is not a controlled substance and does not cause dependence</p> Signup and view all the answers

    What is the maximum recommended dose of zolpidem for older adults or women?

    <p>5 mg</p> Signup and view all the answers

    Which of the following is an important patient education recommendation for the nonbenzodiazepine gaba-ergic drugs?

    <p>Patients should use caution if driving or operating machinery until they know the drug's effect</p> Signup and view all the answers

    What is the peak onset time of suvorexant when taken on an empty stomach?

    <p>2 hours</p> Signup and view all the answers

    Which enzyme is primarily responsible for the metabolism of suvorexant?

    <p>CYP3A4</p> Signup and view all the answers

    Which of the following is NOT a precaution or contraindication for nonbenzodiazepine hypnotics?

    <p>They are approved for use in children.</p> Signup and view all the answers

    Which of the following is a potential adverse effect of suvorexant?

    <p>All of the above</p> Signup and view all the answers

    Which of the following drugs should NOT be used concomitantly with suvorexant?

    <p>Ketoconazole</p> Signup and view all the answers

    Which nonbenzodiazepine hypnotic is NOT a controlled substance?

    <p>Ramelteon</p> Signup and view all the answers

    Which pathway is primarily responsible for the excretion of suvorexant?

    <p>Feces</p> Signup and view all the answers

    Which of the following is a common side effect of nonbenzodiazepine hypnotics?

    <p>All of the above</p> Signup and view all the answers

    Which statement about the nonbenzodiazepine hypnotics is TRUE?

    <p>They are associated with withdrawal signs and symptoms when discontinued.</p> Signup and view all the answers

    Which of the following is a potential adverse effect of suvorexant reported in clinical trials?

    <p>Worsening of suicidal ideation</p> Signup and view all the answers

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