22 Questions
What is the primary mechanism of action of nonbenzodiazepine hypnotics?
They do not act at the GABA receptor, but at a different receptor site
Which of the following is not a nonbenzodiazepine hypnotic?
Zopiclone
What is the primary mechanism of action of ramelteon?
It acts as a melatonin receptor agonist
What is the primary mechanism of action of suvorexant?
It blocks the binding of orexin to its receptors
Which of the following nonbenzodiazepine hypnotics has the shortest half-life?
Zaleplon
Which nonbenzodiazepine hypnotic has the highest protein binding?
Zolpidem
What is the recommended initial dose of suvorexant for a patient not on a moderate CYP3A4 inhibitor?
10 mg
What is the recommended dose of suvorexant for a patient who is on a moderate CYP3A4 inhibitor?
5 mg
Which of the following is NOT a recommended dosing practice for the nonbenzodiazepine gaba-ergic drugs?
Take the medication as needed throughout the day
Which of the following statements about ramelteon is correct?
Ramelteon is not a controlled substance and does not cause dependence
What is the maximum recommended dose of zolpidem for older adults or women?
5 mg
Which of the following is an important patient education recommendation for the nonbenzodiazepine gaba-ergic drugs?
Patients should use caution if driving or operating machinery until they know the drug's effect
What is the peak onset time of suvorexant when taken on an empty stomach?
2 hours
Which enzyme is primarily responsible for the metabolism of suvorexant?
CYP3A4
Which of the following is NOT a precaution or contraindication for nonbenzodiazepine hypnotics?
They are approved for use in children.
Which of the following is a potential adverse effect of suvorexant?
All of the above
Which of the following drugs should NOT be used concomitantly with suvorexant?
Ketoconazole
Which nonbenzodiazepine hypnotic is NOT a controlled substance?
Ramelteon
Which pathway is primarily responsible for the excretion of suvorexant?
Feces
Which of the following is a common side effect of nonbenzodiazepine hypnotics?
All of the above
Which statement about the nonbenzodiazepine hypnotics is TRUE?
They are associated with withdrawal signs and symptoms when discontinued.
Which of the following is a potential adverse effect of suvorexant reported in clinical trials?
Worsening of suicidal ideation
Explore the pharmacodynamics of nonbenzodiazepine hypnotics used to induce sleep, including zolpidem, zaleplon, eszopiclone, and ramelteon. Understand how these drugs act at the GABA receptor but not at the benzodiazepine site.
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