12 Questions
What is the primary mechanism of action for the analgesic and antipyretic effects of salicylates?
Inhibition of prostaglandin synthesis by blocking the cyclooxygenase enzyme
Which of the following is NOT a local action of salicylates?
Antirheumatic
How does aspirin affect uric acid levels?
Aspirin in small doses inhibits uric acid secretion, leading to decreased uric acid levels
What is the primary cardiovascular effect of therapeutic doses of salicylates?
Little to no effect
Which of the following is a unique effect of aspirin compared to other salicylates?
Inhibition of platelet aggregation and prolonged bleeding time
How does the absorption of aspirin differ from other salicylates?
Aspirin is absorbed more effectively from the small intestine due to its low pH
Which of the following is the correct sequence of events in large doses of salicylates?
Increased respiratory center → washing out CO2 → respiratory alkalosis → kidney excretes NaHCO3 → compensated respiratory alkalosis → decreased NaHCO3 in blood → metabolic acidosis
In patients with G-6-PD deficiency, what adverse effect can salicylates cause?
Hemolytic anemia
Which of the following is NOT a gastrointestinal effect of salicylates?
Constipation
What is the mechanism by which salicylates cause prolonged bleeding time in large doses?
Interference with vitamin K metabolism in the liver, leading to hypoprothrombinaemia
Which of the following statements about salicylates and renal function is correct?
Salicylates decrease renal blood flow, which can cause sodium retention and reduced renal function, especially in patients with heart failure or hypovolemia
What is the mechanism by which aspirin toxicity can lead to acidosis?
Uncoupling of oxidative phosphorylation → prevents energy storage/ATP production → stimulates respiratory center → hyperventilation → loss of CO2 → respiratory alkalosis → kidney increases bicarbonate excretion → acidosis
Test your knowledge on non-selective COX inhibitors including Salicylates such as Aspirin. Explore the pharmacokinetics, actions, and excretion of Salicylates. Prepare for questions on the effects and uses of these inhibitors.
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