Non Malignant Leukocyte Disorders
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Questions and Answers

What is the main cause of toxic granulation in leukocytes?

  • Burns and malignant disorders
  • Infectious states
  • Metabolic toxicity within the cells (correct)
  • Drug therapy

Which condition is characterized by prominent dark granulation in band and segmented neutrophils or monocytes?

  • May-Hegglin Anomaly
  • Alder-Reilly Anomaly
  • Toxic Granulation (correct)
  • Pelger-Huët Anomaly

Which abnormality is associated with azurophilic (primary) granules that are peroxidase-positive?

  • Alder-Reilly Anomaly
  • May-Hegglin Anomaly
  • Neutrophil Hypersegmentation
  • Toxic Granulation (correct)

Which condition may lead to the observation of toxic granulation in leukocytes?

<p>Malignant disorders (A)</p> Signup and view all the answers

What is the primary cause of May-Hegglin Anomaly?

<p>Genetic mutation (A)</p> Signup and view all the answers

Which abnormality is characterized by neutrophils with multiple separate cytoplasmic granules?

<p>Alder-Reilly Anomaly (A)</p> Signup and view all the answers

Which cellular structure represents aggregates of rough endoplasmic reticulum associated with a variety of conditions such as viral infections, burns, or certain drugs?

<p>DOHLE BODIES (A)</p> Signup and view all the answers

Which disorder is characterized by decreased nuclear segmentation and a distinctive coarse chromatin clumping pattern?

<p>PELGER HUET ANOMALY (C)</p> Signup and view all the answers

Which autosomal recessive disorder is characterized by granulocytes with large, darkly staining metachromatic cytoplasmic granules?

<p>ALDER REILLY ANOMALY (B)</p> Signup and view all the answers

Which disorder is associated with variable thrombocytopenia, giant platelets, and large Döhle body-like inclusions in neutrophils, eosinophils, basophils, and monocytes?

<p>MAY HEGGLIN ANOMALY (B)</p> Signup and view all the answers

What is the characteristic feature of Neutrophilia with Left Shift?

<p>Increased immature neutrophils (A)</p> Signup and view all the answers

Which group of disorders results from mutations in genes that code for the production of lysosomal enzymes, leading to flawed degradation of phagocytized material and buildup of undigested substrates within lysosomes?

<p>LYSOSOMAL STORAGE DISEASE (A)</p> Signup and view all the answers

Which autosomal dominant disorder is most frequently seen in segmented neutrophils with more than five lobes or nuclear segments?

<p>HYPERSEGMENTATION OF NEUTROPHILS (B)</p> Signup and view all the answers

Which disorder is characterized by large, hypogranular platelets and variable thrombocytopenia?

<p>MAY HEGGLIN ANOMALY (C)</p> Signup and view all the answers

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