22 Questions
Which of the following is NOT a risk factor for Basal Cell Carcinoma?
Acidic diet
What is the main function of Hedgehog proteins?
Regulate cell proliferation and differentiation
Which type of UV radiation is most absorbed by the epidermis and is considered the most carcinogenic?
UV-B
What gene mutation is associated with the development of Basal Cell Carcinoma?
PTCH gene mutation
Which of the following is a microscopic feature of Basal Cell Carcinoma?
Nodules in the dermis
What is the main function of UV radiation in skin tumor development?
Induce p53 mutation
Which type of skin tumor may present with cutaneous horn?
Actinic keratosis
What is considered the primary complete carcinogen related to skin tumors?
UV radiation
Which of the following tumors is NOT associated with nevoid basal cell carcinoma syndrome?
Squamous cell carcinoma in the skin
Which of the following tumors is most commonly associated with Merkel cell carcinoma?
Melanoma
What is a common risk factor for squamous cell carcinoma?
UV exposure
Which of the following microscopic features is characteristic of Merkel cell carcinoma?
Round and vesicular nuclei
What is one of the clinical presentations of Merkel cell carcinoma?
Painless nodules
Which microscopic feature is indicative of Acantholytic Squamous Cell Carcinoma?
Loss of intercellular connection
What feature distinguishes Squamous Cell Carcinoma in situ from invasive SCC under a microscope?
No dermal invasion
What is a characteristic histological pattern of Squamous Cell Carcinoma?
Verrucous
What is the most common type of cutaneous T cell lymphoma described in the text?
Mycosis Fungoides
Which type of lymphoma is CD45+?
Lymphoma
What microscopic feature is associated with the 'Patch' stage of Mycosis Fungoides?
Clustered in epidermis
Which syndrome is commonly associated with erythroderma and lymphadenopathy?
Sézary syndrome
What type of cells are positive for CD4 and negative for CD8 in Sézary syndrome?
Neoplastic T cells w cerebriform nuclei (Sézary cells)
Which stage of Mycosis Fungoides may resemble psoriasis?
Plaque stage
Test your knowledge on nonmelanocytic malignant skin tumors focusing on Actinic Keratosis, its features, biopsy procedures, and the role of UV Radiation in causing DNA damage and mutations. Understand the microscopic characteristics and diagnostic process.
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