12 Questions
Match the following drugs with their primary usage:
Neostigmine, pyridostigmine = Reversal of nondepolarizing blockers Pancuronium = Surgical relaxation Baclofen = Severe spasticity treatment Cyclobenzaprine = Acute muscle spasm treatment
Match the following drugs with their mechanism of action:
Baclofen = GABAB agonist, causes membrane hyper-polarization Diazepam = Facilitates GABAergic transmission in CNS, increases interneuron inhibition Tizanidine = α2-Adrenoceptor agonist in the spinal cord Dantrolene = Blocks RyR1 Ca2+ release channels in the sarcoplasmic reticulum of skeletal muscle
Match the following drugs with their adverse effects:
Baclofen = Sedation, muscle weakness Diazepam = Central sedation Tizanidine = Weakness, sedation, hypotension Cyclobenzaprine = Confusion, visual hallucinations
Match the following drugs with their uses:
Baclofen = Severe spasticity-cerebral palsy, multiple sclerosis, stroke Diazepam = Chronic spasm due to cerebral palsy, stroke, spinal cord injury Tizanidine = Spasm due to multiple sclerosis, stroke, amyotrophic lateral sclerosis Dantrolene = IV: Malignant hyperthermia Oral: Spasm due to cerebral palsy, spinal cord injury, multiple sclerosis
Match the following types of skeletal muscle relaxants with their subtypes:
Neuromuscular blockers = Depolarizing blockers Spasmolytic Drugs = Directly-Acting
Match the following types of drugs for acute muscle spasm with their uses:
Neuromuscular blockers = Interfere with transmission at the neuromuscular end plate Spasmolytics = Traditionally called 'centrally acting' muscle relaxants
Match the following NMJ blockade mechanisms with their descriptions:
Pharmacologic blockade = Prototype of this class is d-tubocurarine The second type of blockade = Prototype of this class is succinylcholine
Match the following neuromuscular blocking agents with their classifications:
Non-depolarizing (Competitive) blockers = Intermediate acting: Atracurium, Rocuronium Depolarizing blockers = More effect on NMJ and less on autonomic ganglia
Match the following depolarizing blocker events with their descriptions:
Phase 1(depolarization block) = Block is due to desensitization of Ach Receptors Phase 2 (desensitization block) = Releases histamine from mast cells
Match the following ADRs with the type of blocker they are associated with:
Respiratory paralysis = Depolarizing Blockers Hyperkalemia = Nondepolarizing Blockers Malignant hyperthermia = Depolarizing Blockers
Match the following descriptions with the type of blocker they correspond to:
Reversible competitive antagonists = These compounds have two charged heads More effect on NMJ and less on autonomic ganglia = Nondepolarizing Blockers Releases histamine from mast cells = Depolarizing Blockers
Match the following order of paralysis with the type of blocker they are associated with:
Neck, limbs face, jaws, eyes pharynx trunk respiratory = Anticholinesterase: do not reverse the paralysis in Phase I
Study Notes
Pharmaceuticals and Muscle Relaxants
Matching Exercises
- Various drugs need to be matched with their primary usage, mechanism of action, adverse effects, and uses
- Skeletal muscle relaxants have subtypes that need to be matched
- Drugs for acute muscle spasm have specific uses that need to be matched
- NMJ blockade mechanisms have descriptions that need to be matched
- Neuromuscular blocking agents have classifications that need to be matched
- Depolarizing blocker events have descriptions that need to be matched
- Adverse drug reactions (ADRs) are associated with specific types of blockers
- Descriptions correspond to specific types of blockers
- Order of paralysis is associated with specific types of blockers
Test your knowledge of neuromuscular blockers and skeletal muscle relaxants with this quiz. Learn about the different types of skeletal muscle relaxants, including neuromuscular blockers such as non-depolarizing and depolarizing blockers, as well as spasmolytic drugs. Explore drugs used for acute muscle spasm and enhance your understanding of these essential pharmacological concepts.
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