Neuromuscular Blockers and Skeletal Muscle Relaxants Quiz
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Questions and Answers

What are the two types of skeletal muscle relaxants mentioned in the text?

Neuromuscular blockers and Spasmolytic Drugs

What are the subtypes of Neuromuscular blockers?

Non-depolarizing (Competitive) blockers and Depolarizing blockers

What are the uses of Neuromuscular blockers?

Surgical procedures, ICU, general anesthesia, tracheal intubation

What are the uses of Spasmolytic Drugs?

<p>Chronic back pain, painful fibromyalgias</p> Signup and view all the answers

What is the mechanism of action of Non-depolarizing (Competitive) blockers?

<p>Reversible competitive antagonists</p> Signup and view all the answers

Name the prototype of Non-depolarizing (Competitive) blockers.

<p>d-tubocurarine</p> Signup and view all the answers

What is the second type of blockade mentioned in the text?

<p>Depolarizing type</p> Signup and view all the answers

Name the prototype of Depolarizing blockers.

<p>Succinylcholine</p> Signup and view all the answers

What are the two sequential events of Depolarizing block?

<p>Phase 1 (depolarization block) and Phase 2 (desensitization block)</p> Signup and view all the answers

What is the effect of Succinylcholine on NMJ and autonomic ganglia?

<p>More effect on NMJ and less on autonomic ganglia</p> Signup and view all the answers

What is the order of paralysis caused by Depolarizing Blockers?

<p>Neck, limbs, face, jaws, eyes, pharynx, trunk, respiratory</p> Signup and view all the answers

What are the adverse drug reactions (ADRs) of Nondepolarizing Blockers?

<p>Respiratory paralysis, Hyperkalemia, Malignant hyperthermia</p> Signup and view all the answers

What are the reversible anti-AChE agents that can reverse the block caused by nondepolarizing blockers?

<p>Neostigmine, pyridostigmine</p> Signup and view all the answers

What can potentiate the effects of nondepolarizing blockers?

<p>Hypokalemia</p> Signup and view all the answers

What group of individuals are sensitive to nondepolarizing blockers?

<p>Newborn and myasthenia patients</p> Signup and view all the answers

Name two adverse effects of nondepolarizing blockers.

<p>Bronchospasm, hypotension</p> Signup and view all the answers

What is the potentiation effect of inhalational anesthetics on nondepolarizing blockers?

<p>Potentiation</p> Signup and view all the answers

Name the nondepolarizing blocker that is 5 times more potent than d-tubocurarine.

<p>Pancuronium</p> Signup and view all the answers

What is the onset time and duration of action of atracurium?

<p>Onset - 2.9 minutes, Duration of action - 110 minutes</p> Signup and view all the answers

What is the rapid onset time and duration of action of rocuronium?

<p>Onset - 1 minute, Duration of action - 55 minutes</p> Signup and view all the answers

What is the onset time and duration of action of mivacurium?

<p>Onset - 1.8 minutes, Duration of action - 20 minutes</p> Signup and view all the answers

Name 3 uses of neuromuscular blocking drugs.

<p>Surgical relaxation, tracheal intubation, control of ventilation</p> Signup and view all the answers

What is the MOA of baclofen, a centrally acting spasmolytic drug?

<p>GABAB agonist causing membrane hyper-polarization via increased K+ conductance</p> Signup and view all the answers

What is the MOA of diazepam, a centrally acting spasmolytic drug?

<p>Facilitates GABAergic transmission in the central nervous system, increases interneuron inhibition of primary motor afferents in spinal cord</p> Signup and view all the answers

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