Recent

  • Show all results for ""

🎧 New: AI-Generated Podcasts Turn your study notes into engaging audio conversations. Learn more

Neuromuscular Blockers and Skeletal Muscle Relaxants
37 Questions
2 Views

Neuromuscular Blockers and Skeletal Muscle Relaxants

Created by
@UncomplicatedFaith

Podcast Beta

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which drug is used for treatment of acute spasm due to muscle injury and inflammation?

  • Diazepam
  • Cyclobenzaprine (correct)
  • Dantrolene
  • Tizanidine

    • What is the mechanism of action of Baclofen?

  • Blocks RyR1 Ca2+ release channels in skeletal muscle
  • Acts as a GABAB agonist causing membrane hyperpolarization (correct)
  • Increases acetylcholine release at the neuromuscular junction
  • Acts as an α2-Adrenoceptor agonist in the spinal cord

    • What is the primary adverse effect of Tizanidine?

  • Visual hallucinations
  • Muscle weakness (correct)
  • Bronchospasm
  • Hypotension

    • Which drug is an antibiotic that enhances the effects of nondepolarizing blockers?

    <p>Neostigmine</p> Signup and view all the answers

    What is the primary use of Dantrolene?

    <p>Malignant hyperthermia</p> Signup and view all the answers

    What is the mechanism of action of Pancuronium?

    <p>Blocks neuromuscular transmission by competitive antagonism at acetylcholine receptors</p> Signup and view all the answers

    Which type of skeletal muscle relaxant reduces spasticity in a variety of painful conditions?

    <p>Spasmolytic Drugs</p> Signup and view all the answers

    What is the prototype of the non-depolarizing neuromuscular blocking drugs?

    <p>d-tubocurarine</p> Signup and view all the answers

    Which type of blockade is caused by an excess of a depolarizing agonist such as acetylcholine?

    <p>Depolarizing block</p> Signup and view all the answers

    Which drug releases histamine from mast cells and has more effect on NMJ than on autonomic ganglia?

    <p>Succinylcholine</p> Signup and view all the answers

    Which type of blocker may prolong the block but does not reverse the paralysis in Phase I?

    <p>Depolarizing blockers</p> Signup and view all the answers

    What is the order of paralysis for non-depolarizing blockers?

    <p>Neck, limbs respiratory face, jaws, eyes</p> Signup and view all the answers

    What is the mechanism of action for non-depolarizing blockers?

    <p>Blockade of end plate function by two basic mechanisms</p> Signup and view all the answers

    Which type of blocker causes maintained depolarization producing Na channel inactivation?

    <p>Non-depolarizing blockers</p> Signup and view all the answers

    Which drug is used for short term procedures and may lead to adverse drug reactions including respiratory paralysis and hyperkalemia?

    <p>Succinylcholine</p> Signup and view all the answers

    What is the effect of anticholinesterase agents on the paralysis caused by depolarizing blockers?

    <p>They prolong the paralysis</p> Signup and view all the answers

    Which drug is a nondepolarizing neuromuscular blocking agent with a rapid onset of 1.8 minutes and duration of action of 20 minutes?

    <p>Mivacurium</p> Signup and view all the answers

    What is NOT the primary adverse effect of Tizanidine?

    <p>Visual hallucinations</p> Signup and view all the answers

    Which drug acts by blocking RyR1 Ca2+ release channels in the sarcoplasmic reticulum of skeletal muscle?

    <p>Dantrolene</p> Signup and view all the answers

    What is the mechanism of action of Baclofen?

    <p>GABAB agonist causing membrane hyper-polarization via increased K+ conductance</p> Signup and view all the answers

    Which drug is used for acute spasm due to muscle injury and inflammation, and has marked sedative and antimuscarinic actions?

    <p>Cyclobenzaprine</p> Signup and view all the answers

    Which drug is an antibiotic that enhances the effects of nondepolarizing blockers?

    <p>Tetracycline</p> Signup and view all the answers

    Which drug is an α2-Adrenoceptor agonist in the spinal cord, reinforcing both presynaptic and postsynaptic inhibition of reflex motor output?

    <p>Tizanidine</p> Signup and view all the answers

    Which drug causes maintained depolarization producing Na channel inactivation?

    <p>Neostigmine</p> Signup and view all the answers

    Which drug has a long onset time of 2.9 minutes and a duration of action of 110 minutes?

    <p>Pancuronium</p> Signup and view all the answers

    What is the primary use of Dantrolene?

    <p>Spasm due to cerebral palsy, spinal cord injury, multiple sclerosis</p> Signup and view all the answers

    Which type of skeletal muscle relaxant acts in the brain stem, possibly by interfering with polysynaptic reflexes that maintain skeletal muscle tone?

    <p>Cyclobenzaprine</p> Signup and view all the answers

    Which drug is a prototype of the depolarizing neuromuscular blocking drugs?

    <p>Succinylcholine</p> Signup and view all the answers

    What is the primary effect of anticholinesterase agents on the paralysis caused by depolarizing blockers?

    <p>Prolongs the block</p> Signup and view all the answers

    What is the order of paralysis for non-depolarizing blockers?

    <p>Neck, limbs, respiratory, face, jaws, eyes</p> Signup and view all the answers

    Which drug releases histamine from mast cells and has more effect on NMJ than on autonomic ganglia?

    <p>Succinylcholine</p> Signup and view all the answers

    What is the mechanism of action of Baclofen?

    <p>Acts as a GABA(B) receptor agonist in the spinal cord</p> Signup and view all the answers

    Which type of blocker causes maintained depolarization producing Na channel inactivation?

    <p>Depolarizing blockers</p> Signup and view all the answers

    What is the primary use of Dantrolene?

    <p>Management of malignant hyperthermia</p> Signup and view all the answers

    Which drug is used for treatment of acute spasm due to muscle injury and inflammation?

    <p>Tizanidine</p> Signup and view all the answers

    What is the mechanism of action of Pancuronium?

    <p>Reversible competitive antagonism at nicotinic acetylcholine receptors.</p> Signup and view all the answers

    What is the effect of anticholinesterase agents on the paralysis caused by non-depolarizing blockers?

    <p>Prolongs the block.</p> Signup and view all the answers

    Study Notes

    Muscle Relaxants

    • Carisoprodol is used to treat acute spasm due to muscle injury and inflammation.
    • Baclofen's mechanism of action involves activation of GABA receptors, which inhibits the release of excitatory neurotransmitters.

    Adverse Effects

    • The primary adverse effect of Tizanidine is sedation.
    • The primary adverse effect of Succinylcholine is hyperkalemia.
    • The primary adverse effect of Tizanidine is not respiratory depression.

    Antibiotics and Muscle Relaxants

    • Aminoglycosides are antibiotics that enhance the effects of non-depolarizing blockers.

    Non-Depolarizing Blockers

    • Dantrolene is used to treat malignant hyperthermia.
    • The mechanism of action of non-depolarizing blockers involves competitive inhibition of acetylcholine at the neuromuscular junction.
    • The order of paralysis for non-depolarizing blockers is: facial, arm, leg, and respiratory muscles.
    • Pancuronium's mechanism of action involves competitive inhibition of acetylcholine at the neuromuscular junction.
    • Rocuronium is a non-depolarizing neuromuscular blocking agent with a rapid onset of 1.8 minutes and a duration of action of 20 minutes.

    Depolarizing Blockers

    • Succinylcholine causes maintained depolarization producing Na channel inactivation.
    • Succinylcholine is used for short-term procedures and may lead to adverse drug reactions including respiratory paralysis and hyperkalemia.

    Anticholinesterase Agents

    • Anticholinesterase agents reverse the paralysis caused by depolarizing blockers.
    • Anticholinesterase agents have no effect on the paralysis caused by non-depolarizing blockers.

    Other Muscle Relaxants

    • Tizanidine is an α2-Adrenoceptor agonist in the spinal cord, reinforcing both presynaptic and postsynaptic inhibition of reflex motor output.
    • Cyclobenzaprine acts in the brain stem, possibly by interfering with polysynaptic reflexes that maintain skeletal muscle tone.
    • Succinylcholine is a prototype of the depolarizing neuromuscular blocking drugs.
    • Dantrolene acts by blocking RyR1 Ca2+ release channels in the sarcoplasmic reticulum of skeletal muscle.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    12- SKM RELAXANTS.pdf

    Description

    Test your knowledge about neuromuscular blockers and skeletal muscle relaxants. Learn about the neuromuscular junction, types of skeletal muscle relaxants, and drugs for acute muscle spasm.

    More Quizzes Like This

    Neuromuscular Blocking Agents and Adverse Effects
    6 questions

    Neuromuscular Blocking Agents and Adverse Effects

    YouthfulTsilaisite avatar
    YouthfulTsilaisite
    Neuromuscular Blockers (NMBs) Classification
    10 questions

    Neuromuscular Blockers (NMBs) Classification

    SnazzyRhodolite avatar
    SnazzyRhodolite
    Kas Spazmını Azaltmak ve Diğer Hastalıklar
    15 questions

    Kas Spazmını Azaltmak ve Diğer Hastalıklar

    ThrilledFermat avatar
    ThrilledFermat
    Farmacología: Relajantes Neuromusculares
    31 questions

    Farmacología: Relajantes Neuromusculares

    CheerySupernova1771 avatar
    CheerySupernova1771
    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser