17 Questions
What is associated with the presence of follicles in meninges?
Earlier onset of disease and faster accumulation of disability
What breaks microglia tolerance, according to van der Poel et al.?
IgG-production
In PPMS autopsies, what type of demyelination is more common in cortical lesions compared to white matter?
Grey matter demyelination
What correlates with the perivascular enrichment of CD4+ T cells?
CD38+ B cells
What is affected by the working model of parenchymal tissue damage?
Cytokines and IgG production
What is the name of the genetic variant associated with a 5-fold increased risk of developing multiple sclerosis?
HLA-DRB1*15:01
Which of the following immune cells is expanded, activated, and associated with multiple sclerosis lesions?
Tissue-resident memory T cells
What is the effect of disease-modifying therapies on the sequence of events in lymph nodes?
They alter the sequence of events
What is the name of the molecules found in cervical lymph nodes that are specific to the brain?
Brain-specific molecules
Which of the following is a characteristic of circulating T cell subsets in multiple sclerosis?
They are increased in people with MS
What is the role of meningeal lymphatic vessels in the initiation of the detrimental immune response in multiple sclerosis?
Their role is controversial
What percentage of patients display grey matter lesions?
38%
Which type of cells are responsible for 41% of lesions in MS patients?
Macrophages
What is associated with meningeal inflammation in MS?
Grey matter lesions
Which B cell subset is associated with CD4+ TRM cells in MS lesions?
CD27+CD38high CXCR3+
What is the median disease duration to autopsy in MS patients?
3 months
What type of immune cells are activated in MS and cross the inflamed endothelium?
Activated immune cells
This quiz covers the diagnosis and treatment of Multiple Sclerosis, including clinical profiles, supportive evidence, and disease-modifying drugs. Learn about the genetic and environmental risk factors, as well as the symptoms and treatment options.
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