BMS wk 5 lec 1
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Questions and Answers

What is the primary consequence of demyelination on neuronal function?

  • Enhanced synaptic transmission
  • Increased neuronal excitability
  • Impaired neuronal conduction (correct)
  • Augmented neural reflexes
  • Which of the following is a key diagnostic aspect of multiple sclerosis?

  • Electromyography
  • Positron emission tomography (PET)
  • Electroencephalography (EEG)
  • Magnetic resonance imaging (MRI) (correct)
  • What is the term for a disease that affects multiple nerves simultaneously?

  • Neuropathy
  • Radiculopathy
  • Polyneuropathy (correct)
  • Mononeuropathy
  • Which pattern of MS progression is characterized by a steady decline in neurological function?

    <p>Primary progressive MS</p> Signup and view all the answers

    What is the pathophysiologic mechanism by which nerve compression leads to neurological damage?

    <p>Axonal degeneration</p> Signup and view all the answers

    What is the term for inflammation of a nerve?

    <p>Neuritis</p> Signup and view all the answers

    What is the prognosis of Guillain-Barré syndrome?

    <p>Good, with most patients experiencing a full recovery</p> Signup and view all the answers

    What is the term for a condition that affects the facial nerve, leading to weakness or paralysis of the facial muscles?

    <p>Bell’s palsy</p> Signup and view all the answers

    What is the primary difference between an active and an inactive plaque in MS?

    <p>Degree of inflammation</p> Signup and view all the answers

    Study Notes

    Compressive and Demyelinating Illness in the Central Nervous System

    • Describe the pathophysiologic mechanisms of demyelination and its consequences on neuronal function
    • Develop a model of the pathophysiology of Multiple Sclerosis (MS) incorporating:
      • Pathological findings
      • Immunological mechanisms
      • Known etiological factors

    Multiple Sclerosis (MS)

    • General epidemiology
    • Common clinical features
    • Key diagnostic aspects
    • Three major patterns of MS progression
    • Major signs and symptoms typical of early MS
    • Clinical features of flares and periods in between flares
    • Pathologic appearance of an active and inactive plaque
    • Define:
      • Neuropathy
      • Neuralgia
      • Neuritis
      • Radiculopathy
      • Polyneuropathy
      • Multiple mononeuropathy

    Hereditary Sensory and Motor Neuropathies

    • Basic epidemiology
    • Pathogenesis
    • Major clinical features
    • Prognosis

    Guillain-Barre Syndrome

    • Basic epidemiology
    • Pathogenesis
    • Major clinical features
    • Prognosis

    Nerve Compression

    • Pathophysiologic mechanisms leading to neurological damage

    Bell's Palsy

    • Basic epidemiology
    • Pathogenesis
    • Major clinical features
    • Prognosis

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    Description

    Understand the mechanisms of demyelination, its effects on neuronal function, and the pathophysiology of Multiple Sclerosis, including epidemiology, clinical features, and diagnosis. Develop a model incorporating pathological, immunological, and etiological factors.

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