Microbiology and Antibiotics Mechanisms Lecture Notes

Peptidoglycan synthesis begins with the stepwise synthesis in the cytoplasm of UDP-N-acetylmuramic acid-______

The synthesis of UDP-N-acetylmuramic acid-pentapeptide involves the condensation of N-Acetylglucosamine with uridine diphosphate and then conversion to UDP-N-acetylmuramic acid by condensation with phosphoenolpyruvate and reduction in a series of ______

The amino acids of the pentapeptide are sequentially added without the involvement of ribosomes and tRNA, instead, each addition is catalyzed by a different enzyme and involves the split of ______ to ADP + Pi

The final cross-linking of peptidoglycan is accomplished by a transpeptidation reaction in which the free amino group of a pentaglycine residue displaces the terminal D-alanine residue of a neighboring pentapeptide, catalyzed by one of a set of enzymes called ______

D-Cycloserine interferes with one of the early stages of synthesis of peptidoglycan involving the assembly of the dipeptide D-alanyl-D-alanine by inhibiting the racemase enzyme which converts L-alanine to D-alanine and a ______ which couples two D-alanines together