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Questions and Answers
What is the therapeutic class of metoclopramide (Reglan)?
List one indication for metoclopramide (Reglan).
Nausea and vomiting from chemotherapy
What is one major mechanism of action for metoclopramide (Reglan)?
Blocks dopamine receptors in the central nervous system.
Which of the following are common side effects of metoclopramide (Reglan)? (Select all that apply)
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What is the typical adult dosage for metoclopramide (Reglan) via IM/IV for nausea and vomiting?
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Administer metoclopramide (Reglan) IV push over ______ minutes.
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Name one nursing intervention for patients taking metoclopramide (Reglan).
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Neuroleptic malignant syndrome is not a side effect of metoclopramide (Reglan).
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What should be monitored in patients taking metoclopramide (Reglan) for neuroleptic malignant syndrome?
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Study Notes
Metoclopramide (Reglan) Overview
- Classified as an antiemetic, used primarily to prevent nausea and vomiting.
Indications
- Effective for nausea and vomiting (N/V) caused by chemotherapy or post-operative conditions.
- Treats gastric stasis, promoting digestion and bowel movement.
- Facilitates intubation for radiologic procedures.
- Used in managing gastroesophageal reflux disease (GERD).
Mechanism of Action
- Blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) of the central nervous system (CNS).
- Stimulates upper gastrointestinal motility, enhancing gastric emptying.
Side Effects
- Common CNS effects include drowsiness, restlessness, and extrapyramidal reactions.
- Serious risks include neuroleptic malignant syndrome, characterized by hyperthermia and muscle rigidity.
- Cardiovascular effects: arrhythmias, hypotension, and hypertension.
- Gastrointestinal issues include diarrhea and dry mouth.
Dosing Information
- Standard adult dosage is 10 mg IM/IV every 6 hours for nausea and vomiting.
- IV push administration recommended over 1-2 minutes.
Nursing Interventions
- Continuously assess for nausea, vomiting, abdominal distention, and bowel sounds.
- Monitor for extrapyramidal side effects and signs of tardive dyskinesia (uncontrolled, rhythmic movements).
- Check for symptoms of neuroleptic malignant syndrome including hyperthermia and altered consciousness.
- Advise patients to avoid alcohol and other CNS depressants due to increased drowsiness risk.
Patient Education and Monitoring
- Instruct patients to report any tremors or uncontrollable muscle contractions immediately.
- Encourage hydration and advise avoiding extreme temperatures.
- Observe for symptoms of depression in patients.
- Regularly monitor liver function and aldosterone levels to ensure safety and efficacy.
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Description
This quiz provides an overview of Metoclopramide, including its indications, mechanism of action, side effects, and dosing recommendations. Test your knowledge on this important antiemetic medication and its role in treating nausea, gastric stasis, and GERD.
