Pharmacology of Gastrointestinal Drugs
43 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary pharmacological effect of dexpanthenol?

  • Increases GI motility by inhibiting parasympathetic action
  • Increases acetylcholine levels to stimulate parasympathetic activity (correct)
  • Decreases the sensitivity of GI tissues to parasympathetic activity
  • Promotes GI obstruction by slowing down peristalsis

Which adverse effect is most commonly associated with gastrointestinal stimulants?

  • Nausea (correct)
  • Drowsiness
  • Constipation
  • Heart palpitations

What is a contraindication for the use of gastrointestinal stimulants?

  • History of allergy to these drugs (correct)
  • Hypertension
  • Diabetes mellitus
  • Chronic pain conditions

How does the pharmacokinetic profile of metoclopramide differ from that of dexpanthenol?

<p>Metoclopramide has a peak effect within 60-90 minutes, whereas dexpanthenol peaks in 4 hours (C)</p> Signup and view all the answers

Which of the following statements regarding metoclopramide is true?

<p>It can lead to decreased absorption of digoxin from the gastrointestinal tract (A)</p> Signup and view all the answers

What is the primary mechanism of action for loperamide in treating diarrhea?

<p>Slowing activity through direct action on GIT muscles (D)</p> Signup and view all the answers

Which of the following antidiarrheals is classified as a category C-III controlled substance?

<p>Opium derivatives (C)</p> Signup and view all the answers

What adverse effect is specifically associated with the use of opium derivatives as antidiarrheals?

<p>Toxic megacolon (C)</p> Signup and view all the answers

Which antidiarrheal is minimally absorbed and primarily acts locally in the GIT?

<p>Crofelemer (C)</p> Signup and view all the answers

In which scenarios should caution be taken when administering antidiarrheals?

<p>In cases of GI obstruction and hepatic impairment (B)</p> Signup and view all the answers

What is the primary function of antacids in the gastrointestinal system?

<p>Neutralize stomach acid (C)</p> Signup and view all the answers

Which of the following is not a commonly prescribed H2 receptor antagonist?

<p>Omeprazole (B)</p> Signup and view all the answers

What effect do H2 receptor antagonists have on gastric acid secretion?

<p>They block gastric acid secretion (A)</p> Signup and view all the answers

What is a potential adverse reaction associated with H2 receptor antagonists?

<p>Headache (A)</p> Signup and view all the answers

How do proton pump inhibitors (PPIs) inhibit gastric acid production?

<p>By disrupting chemical binding in stomach cells (A)</p> Signup and view all the answers

When are proton pump inhibitors primarily indicated?

<p>Short-term treatment of active gastric and duodenal ulcers (C)</p> Signup and view all the answers

What is a primary action of Misoprostol in the treatment of gastric ulcers?

<p>Inhibits gastric acid secretion and increases mucous production (D)</p> Signup and view all the answers

What can decrease the absorption of H2 receptor antagonists?

<p>Antacids (B)</p> Signup and view all the answers

Which of the following statements about antacids is correct?

<p>They can interfere with the absorption of oral medications when taken concurrently (A)</p> Signup and view all the answers

Which of the following is a common side effect associated with proton pump inhibitors?

<p>Dry mouth (B)</p> Signup and view all the answers

What is the role of H2 receptor antagonists in treating Zollinger-Ellison Syndrome?

<p>Reduce gastric acid production (A)</p> Signup and view all the answers

Sucralfate primarily works by forming a protective barrier in which part of the body?

<p>Stomach lining (D)</p> Signup and view all the answers

Which condition is Misoprostol specifically contraindicated in?

<p>Allergy to any part of the drug (B)</p> Signup and view all the answers

What might occur if cimetidine is taken alongside anticoagulants?

<p>Increased blood levels of anticoagulants (C)</p> Signup and view all the answers

What is a key contraindication for the use of Sucralfate?

<p>Renal failure or dialysis (D)</p> Signup and view all the answers

Which side effects are primarily associated with Misoprostol?

<p>Nausea, diarrhea, and abdominal pain (D)</p> Signup and view all the answers

Which interaction occurs with proton pump inhibitors affecting drug metabolism?

<p>Increased half-lives of diazepam and warfarin (C)</p> Signup and view all the answers

What should be monitored when combining aluminum salts with Sucralfate?

<p>High aluminum levels (D)</p> Signup and view all the answers

Which of the following patients should avoid using a proton pump inhibitor?

<p>A patient with a known allergy to the drug (D)</p> Signup and view all the answers

What effect does Sucralfate have on pepsin activity in gastric juices?

<p>Inhibits pepsin activity (C)</p> Signup and view all the answers

What is the primary action of chemical stimulants in the gastrointestinal tract?

<p>Directly stimulate nerve plexus causing increased movement (C)</p> Signup and view all the answers

Which chemical stimulant is specifically noted for causing a thorough evacuation of the intestine?

<p>Castor oil (D)</p> Signup and view all the answers

What is a common adverse effect associated with the use of laxatives?

<p>Diarrhea (B)</p> Signup and view all the answers

Which of the following laxatives is classified as a bulk stimulant?

<p>Polyethylene glycol (D)</p> Signup and view all the answers

When should docusate be used with caution?

<p>In patients with heart block and CAD (C)</p> Signup and view all the answers

What is a distinct characteristic of bulk stimulants?

<p>They cause fecal matter to increase in bulk. (D)</p> Signup and view all the answers

Which laxative works by pulling fluid out of the systemic circulation into the intestinal lumen?

<p>Lactulose (C)</p> Signup and view all the answers

What effect does excessive use of mineral oil have concerning dietary components?

<p>Interferes with fat-soluble vitamin absorption (A)</p> Signup and view all the answers

What is the general onset time for castor oil's action?

<p>2-6 hours (A)</p> Signup and view all the answers

What caution should be considered when using polyethylene glycol electrolyte solution?

<p>Use with extreme caution in patients with a history of seizures (D)</p> Signup and view all the answers

Which laxative primarily acts as a hyperosmolar agent to facilitate evacuation?

<p>Glycerin (D)</p> Signup and view all the answers

Bisacodyl's mechanism of action can best be described as:

<p>Stimulating activity in the lower gastrointestinal tract (D)</p> Signup and view all the answers

Which of the following is NOT a common GI adverse effect of laxatives?

<p>Heartburn (A)</p> Signup and view all the answers
Use Quizgecko on...
Browser
Browser