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Questions and Answers
What is the generic/trade name for Metoclopramide?
What is the generic/trade name for Metoclopramide?
What is the classification of Metoclopramide?
What is the classification of Metoclopramide?
Antiemetic
What is the mechanism of action of Metoclopramide?
What is the mechanism of action of Metoclopramide?
D2 (Dopamine) R antagonist
What is the onset time for Metoclopramide when administered intravenously?
What is the onset time for Metoclopramide when administered intravenously?
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What are the indications for using Metoclopramide?
What are the indications for using Metoclopramide?
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Which of the following are contraindications for using Metoclopramide? (Select all that apply)
Which of the following are contraindications for using Metoclopramide? (Select all that apply)
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What are some side effects of Metoclopramide? (Select all that apply)
What are some side effects of Metoclopramide? (Select all that apply)
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What is the recommended dosage of Metoclopramide?
What is the recommended dosage of Metoclopramide?
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Metoclopramide is contraindicated in children.
Metoclopramide is contraindicated in children.
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What precaution should be taken due to the possible effects of Metoclopramide?
What precaution should be taken due to the possible effects of Metoclopramide?
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What are some drug-drug interactions associated with Metoclopramide? (Select all that apply)
What are some drug-drug interactions associated with Metoclopramide? (Select all that apply)
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Study Notes
Metoclopramide Overview
- Metoclopramide is available as both a generic name and under the trade name Reglan.
- It is classified as an antiemetic, used primarily to prevent nausea and vomiting.
Mechanism of Action
- Functions as a D2 (Dopamine) receptor antagonist.
- Blocks signals from the chemoreceptor trigger zone to the vomiting center, reducing nausea.
- Inhibits gastric smooth muscle relaxation, leading to increased motility of stomach contents into the small intestine.
Pharmacokinetics
- Rapid onset: 1-3 minutes when administered intravenously (IV), 10-15 minutes intramuscularly (IM).
- Peak effect occurs within 1-2 hours.
- Duration of action is approximately 1-3 hours.
- Half-life ranges from 2.5 to 6 hours.
Indications
- Primarily indicated for the management of nausea and vomiting.
Contraindications
- Not recommended for patients with potential gastrointestinal hemorrhage, bowel obstruction, or perforation.
- Caution in patients with seizure disorders, pheochromocytoma, or known hypersensitivity to the drug.
Side Effects
- Common side effects include drowsiness, fatigue, sedation, and dizziness.
- May cause CNS depression, variations in blood pressure (HTN or hypotension), and changes in heart rate (tachycardia or bradycardia).
- Gastrointestinal issues such as diarrhea may occur.
Dosage
- Recommended dosage: 10 mg slow IV administration over 1-2 minutes or 10-20 mg IM.
- Not advised for pediatric use.
Precautions
- Potential for inducing dystonia; careful monitoring is essential.
- Increased risk of dystonia when used concurrently with phenothiazines.
Drug-Drug Interactions
- Anticholinergics, such as atropine, may counteract metoclopramide's effects.
- Additive effects may occur with other CNS depressants like narcotics, sedatives, hypnotics, and alcohol.
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Description
Explore the essentials of Metoclopramide, an antiemetic medication known for preventing nausea and vomiting. This quiz covers its mechanism of action, pharmacokinetics, indications, and contraindications, providing a comprehensive overview for students and healthcare professionals alike.
