12 Questions
What is the driving force for Na+ influx at resting membrane potentials?
Greater concentration of Na+ outside the cell than inside
What triggers the firing of an action potential by the muscle cell?
Depolarization of the muscle membrane
How many acetylcholine molecules bind to the nicotinic acetylcholine receptor to activate it?
2
What is the primary location of acetylcholinesterase (AChE) in the neuromuscular junction?
In the clefts of the neuromuscular junction
What is the central problem of the neuromuscular junction?
Translating neuronal signals to muscular signals at a sustainable rate
What is the key concept about the neuromuscular junction?
It is characterized by extensive folding of the membrane at the postsynaptic site
What are the objectives related to the neuromuscular junction?
Explaining how drugs and toxins can affect the neuromuscular junction
What is the main characteristic of the neuromuscular junction?
Sustainable translation of motor neuron signals to muscle cell signals
What is the role of the presynaptic membrane?
To release ACh into the synaptic cleft
What is the function of rapsyn at the neuromuscular junction?
To cluster nicotinic acetylcholine receptors
How does the amount of ACh in a synaptic vesicle impact the postsynaptic membrane?
It causes a 0.3 to 0.5 mV depolarization
What happens when voltage-gated Ca+2 channels on the presynaptic membrane allow Ca+2 to enter the cytoplasm?
Vesicles dock and become competent to release neurotransmitter
Test your understanding of the neuromuscular junction and its role in translating neuronal electrical signals to muscular electrical signals. Explore the sustainable nature of this process across a wide range of neuronal firing frequencies.
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